Behcet Syndrome Follow-up
- Author: C Egla Rabinovich, MD, MPH; Chief Editor: Lawrence K Jung, MD more...
Further Inpatient Care
- Patients with Behçet syndrome may need to be admitted during acute flares for intravenous therapy or for diagnostic testing or surgical intervention.
Further Outpatient Care
- Close follow-up care is warranted to monitor clinical status, including routine eye examinations.
Inpatient & Outpatient Medications
- Medications (see Medication) vary depending on the clinical manifestations. Monitor drug side effects and efficacy closely.
Transfer
- Transfer to a tertiary care center for diagnosis and intervention may be warranted, depending on the clinical symptomatology.
Deterrence/Prevention
- No preventative measures are known for Behçet syndrome.
Complications
- Complications include those caused by medications and the primary disease, and they vary depending on clinical presentation and disease manifestations.
Prognosis
- Prognosis depends on clinical manifestations. The worst prognoses are associated with retinal vasculitis, leading to blindness; vascular aneurysm formation, with possible rupture; and neuro–Behçet syndrome, which may lead to dementia despite appropriate aggressive treatment.
Patient Education
- Patients must be educated in disease manifestations, long-term prognosis, and medication side effects.
Al-Araji A, Kidd DP. Neuro-Behcet's disease: epidemiology, clinical characteristics, and management. Lancet Neurol. Feb 2009;8(2):192-204. [Medline].
Ebert EC. Gastrointestinal manifestations of Behçet's disease. Dig Dis Sci. Feb 2009;54(2):201-7. [Medline].
Ihle J, Kummerle-Deschner J, Orlikowsky T, Albert E, Niethammer D, Dannecker GE. Factor V Leiden and venous thrombosis in a 4-yr-old girl with Behcet's syndrome. Rheumatology (Oxford). Feb 2000;39(2):209-10. [Medline].
[Guideline] Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A. EULAR recommendations for the management of Behçet disease. Ann Rheum Dis. Dec 2008;67(12):1656-62. [Medline].
Alpsoy E. Behcet's disease: treatment of mucocutaneous lesions. Clin Exp Rheumatol. Jul-Aug 2005;23(4):532-9. [Medline].
Fresko I, Soy M, Hamuryudan V, et al. Genetic anticipation in Behcet's syndrome. Ann Rheum Dis. Jan 1998;57(1):45-8. [Medline].
Gerber S, Biondi A, Dormont D, Wechsler B, Marsault C. Long-term MR follow-up of cerebral lesions in neuro-Behcet's disease. Neuroradiology. Nov 1996;38(8):761-8. [Medline].
Kesen MR, Goldstein DA, Tessler HH. Uveitis associated with pediatric Behcet disease in the american midwest. Am J Ophthalmol. Dec 2008;146(6):819-27.e2. [Medline].
Kikuchi H, Aramaki K, Hirohata S. Effect of infliximab in progressive neuro-Behcet's syndrome. J Neurol Sci. Sep 15 2008;272(1-2):99-105. [Medline].
Kone-Paut I, Geisler I, Wechsler B, et al. Familial aggregation in Behcet's disease: high frequency in siblings and parents of pediatric probands. J Pediatr. Jul 1999;135(1):89-93. [Medline].
Marshall SE. Behcet's disease. Best Pract Res Clin Rheumatol. Jun 2004;18(3):291-311. [Medline].
Martini A. Behcet's disease and Takayasu's disease in children. Curr Opin Rheumatol. Sep 1995;7(5):449-54. [Medline].
[Best Evidence] Melikoglu M, Fresko I, Mat C, et al. Short-term trial of etanercept in Behçet's disease: a double blind, placebo controlled study. J Rheumatol. Jan 2005;32(1):98-105. [Medline].
Nakamura S, Ohno S. Anti-tumor necrosis factor alpha antibody in the treatment of Behcet's disease. Int Ophthalmol Clin. 2005;45(2):179-89. [Medline].
Oktem-Tanor O, Baykan-Kurt B, Gurvit IH, et al. Neuropsychological follow-up of 12 patients with neuro-Behcet disease. J Neurol. Feb 1999;246(2):113-9. [Medline].
Rakavor Y, Adar H, Tal I, et al. Behcet Disease: Long-term follow-up of three children and review of the literature. Pediatrics. 1989;83:986-92. [Medline].
Sakane T, Takeno M, Suzuki N, Inaba G. Behcet's disease. N Engl J Med. Oct 21 1999;341(17):1284-91. [Medline].
Tabbara KF, Al-Hemidan AI. Infliximab effects compared to conventional therapy in the management of retinal vasculitis in Behçet disease. Am J Ophthalmol. Dec 2008;146(6):845-50.e1. [Medline].
Yazici H, Pazarli H, Barnes CG, et al. A controlled trial of azathioprine in Behcet's syndrome. N Engl J Med. Feb 1 1990;322(5):281-5. [Medline].

