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Transient Synovitis Medication

  • Author: Christine C Whitelaw, MD; Chief Editor: Lawrence K Jung, MD  more...
 
Updated: Oct 11, 2015
 
 

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Class Summary

These agents have analgesic, antiinflammatory, and antipyretic activities. They act by inhibiting cyclooxygenase activity, which results in decreased prostaglandin synthesis. Other mechanisms, such as inhibition of leukotriene synthesis, lysosomal enzyme release, lipoxygenase activity, neutrophil aggregation, and various cell-membrane functions, may also exist.

Naproxen and ibuprofen are the most frequently prescribed NSAIDs in children, with a suspension form and safety and efficacy studies available. The COX-2 inhibitors have not yet been studied adequately in the pediatric population.

Naproxen (Aleve, Naprosyn, Anaprox)

 

NSAID that inhibits cyclooxygenase, thus inhibiting formation of prostaglandins.

Ibuprofen (Motrin, Advil)

 

NSAID that inhibits cyclooxygenase, thus inhibiting formation of prostaglandins.

 
 
Contributor Information and Disclosures
Author

Christine C Whitelaw, MD Clinician, Department of Pediatrics, Division of Emergency Medicine, University of Louisville School of Medicine

Christine C Whitelaw, MD is a member of the following medical societies: American Academy of Pediatrics, Kentucky Medical Association

Disclosure: Nothing to disclose.

Coauthor(s)

Kenneth N Schikler, MD Professor, Department of Pediatrics, Director, Divisions of Pediatric Rheumatology and Adolescent Medicine, University of Louisville School of Medicine and Kosair Children's Hospital; Professor (Part-time), Department of Pediatrics, University of Kentucky College of Medicine

Kenneth N Schikler, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Rheumatology, Society for Adolescent Health and Medicine, Childhood Arthritis and Rheumatology Research Alliance

Disclosure: Nothing to disclose.

Specialty Editor Board

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Thomas JA Lehman, MD FAAP, FACR, Clinical Professor of Pediatrics, Department of Pediatrics, Division of Pediatric Rheumatology, Weill Cornell Medical College; Chief, Hospital for Special Surgery

Thomas JA Lehman, MD is a member of the following medical societies: PM American Allergy Society

Disclosure: Nothing to disclose.

Chief Editor

Lawrence K Jung, MD Chief, Division of Pediatric Rheumatology, Children's National Medical Center

Lawrence K Jung, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Rheumatology, Clinical Immunology Society, New York Academy of Sciences

Disclosure: Nothing to disclose.

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Widening of the joint space. Note that the space is wider on the left side. Discrepancies greater than 1 mm indicate the presence of fluid.
 
 
 
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