Vasculitis and Thrombophlebitis Differential Diagnoses

  • Author: Nadia Jennifer Chiara Luca, MD; Chief Editor: Lawrence K Jung, MD   more...
 
Updated: Oct 15, 2010
 
 

Differential Diagnoses

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Contributor Information and Disclosures
Author

Nadia Jennifer Chiara Luca, MD  Fellow in Pediatric Rheumatology, University of Toronto Faculty of Medicine, Canada

Disclosure: Nothing to disclose.

Coauthor(s)

Susanne Maria Benseler, MD  Staff Physician, Research Director, Division of Rheumatology, Associate Professor, University of Toronto Faculty of Medicine; Associate Scientist, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Canada

Disclosure: Nothing to disclose.

Specialty Editor Board

Barry L Myones, MD  Associate Professor, Departments of Pediatrics and Immunology, Pediatric Rheumatology Section, Baylor College of Medicine; Director of Research, Pediatric Rheumatology Center, Texas Children's Hospital

Barry L Myones, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American College of Rheumatology, American Heart Association, American Society for Microbiology, Clinical Immunology Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Mary L Windle, PharmD  Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Herbert S Diamond, MD  Adjunct Professor of Medicine, Division of Rheumatology, University of Pittsburgh School of Medicine; Chairman Emeritus, Department of Internal Medicine, Western Pennsylvania Hospital

Herbert S Diamond, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American College of Rheumatology, American Medical Association, and Phi Beta Kappa

Disclosure: Merck Ownership interest Other; Smith Kline Ownership interest Other; Zimmer Ownership interest Other

Daniel Rauch, MD, FAAP  Director, Pediatric Hospitalist Program, Associate Professor, Department of Pediatrics, New York University School of Medicine

Daniel Rauch, MD, FAAP is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Society of Hospital Medicine

Disclosure: Baxter Honoraria Consulting

Chief Editor

Lawrence K Jung, MD  Chief, Division of Pediatric Rheumatology, Children's National Medical Center

Lawrence K Jung, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Rheumatology, Clinical Immunology Society, and New York Academy of Sciences

Disclosure: Nothing to disclose.

Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous author, Christine Hom, MD, to the development and writing of this article.

References

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Preferred sites of vascular involvement by selected vasculitides.
Patient with Wegener granulomatosis and saddle-nose deformity.
Tender erythematous nodules in cutaneous polyarteritis nodosa (PAN).
Nodules on sole of foot in cutaneous polyarteritis nodosa (PAN).
Necrotic lesions of polyarteritis nodosa (PAN).
Chest radiography in Churg-Strauss syndrome (CSS) with pulmonary infiltrates.
CT of sinuses in a patient with Wegener granulomatosis (WG) showing erosion and loss of sinus walls.
CT chest in a patient with Churg-Strauss syndrome (CSS) showing multiple nodules.
Table 1. EUVAS disease categorization of ANCA-associated vasculitis
CategoryDefinition
LocalizedUpper and/or lower respiratory tract disease without any other systemic



involvement or constitutional symptoms



Early



systemic



Any, without organ-threatening or life-threatening disease
GeneralizedRenal or other organ-threatening disease, serum creatinine >500



μmol/L (5.6 mg/dL)



SevereRenal or other vital organ failure, serum creatinine >500 μmol/L (5.6 mg/dL)
RefractoryProgressive disease unresponsive to glucocorticoids and cyclophosphamide
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