eMedicine Specialties > Pediatrics: General Medicine > Rheumatology

Sjogren Syndrome: Multimedia

Author: Eyal Muscal, MD, Assistant Professor, Section of Pediatric Rheumatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital
Coauthor(s): Marietta Morales de Guzman, MD, Assistant Professor, Department of Pediatrics, Baylor College of Medicine; Consulting Staff, Section of Pediatric Rheumatology, Department of Pediatrics, Texas Children's Hospital, Ben Taub General Hospital; Lawrence K Jung, MD, Chief, Division of Pediatric Rheumatology, Children's National Medical Center; Catherine M Flaitz, DDS, MS, Professor of Oral and Maxillofacial Pathology and Pediatric Dentistry, Department of Diagnostic Sciences, University of Texas Health Sciences Center at Houston, Dental Branch
Contributor Information and Disclosures

Updated: Sep 18, 2009

Multimedia

Lower facial appearance of a 14-year-old adolesce...
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Media file 1: Lower facial appearance of a 14-year-old adolescent girl with Sjögren syndrome. She exhibits both parotid and submandibular gland enlargement and chapped lips.
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Lower facial appearance of a 14-year-old adolesce...

Lower facial appearance of a 14-year-old adolescent girl with Sjögren syndrome. She exhibits both parotid and submandibular gland enlargement and chapped lips.

Intraoral view of a 14-year-old adolescent girl w...
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Media file 2: Intraoral view of a 14-year-old adolescent girl with Sjögren syndrome (see Media file 1). Hyposalivation results in erythema of the mucosa, gingivitis, decalcification or white spot lesions of the teeth at the cervical margin, and dental caries with extensive restorations of the posterior teeth.
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Intraoral view of a 14-year-old adolescent girl w...

Intraoral view of a 14-year-old adolescent girl with Sjögren syndrome (see Media file 1). Hyposalivation results in erythema of the mucosa, gingivitis, decalcification or white spot lesions of the teeth at the cervical margin, and dental caries with extensive restorations of the posterior teeth.

Erythema of the labial mucosa with enlargement of...
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Media file 3: Erythema of the labial mucosa with enlargement of the minor salivary glands and superficial mucoceles.
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Erythema of the labial mucosa with enlargement of...

Erythema of the labial mucosa with enlargement of the minor salivary glands and superficial mucoceles.

The dorsal surface of the tongue demonstrates gen...
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Media file 4: The dorsal surface of the tongue demonstrates generalized atrophy of the filiform papillae, mild fissuring, and median rhomboid glossitis.
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The dorsal surface of the tongue demonstrates gen...

The dorsal surface of the tongue demonstrates generalized atrophy of the filiform papillae, mild fissuring, and median rhomboid glossitis.

A 14-year-old adolescent girl with Sjögren s...
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Media file 5: A 14-year-old adolescent girl with Sjögren syndrome (see Media file 1) with painful unilateral swelling of the knee and hyperpigmentation of the overlying skin.
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A 14-year-old adolescent girl with Sjögren s...

A 14-year-old adolescent girl with Sjögren syndrome (see Media file 1) with painful unilateral swelling of the knee and hyperpigmentation of the overlying skin.

The dorsal tongue demonstrates hyperplastic candi...
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Media file 6: The dorsal tongue demonstrates hyperplastic candidiasis with focal erosions and a brown hairy tongue. Ulcerated fissures are observed on the corners of the mouth that represent angular cheilitis.
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The dorsal tongue demonstrates hyperplastic candi...

The dorsal tongue demonstrates hyperplastic candidiasis with focal erosions and a brown hairy tongue. Ulcerated fissures are observed on the corners of the mouth that represent angular cheilitis.

Biopsy of the minor salivary glands of the lower ...
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Media file 7: Biopsy of the minor salivary glands of the lower lip may be useful in the diagnosis of Sjögren syndrome. A 1.5- to 2-cm incision of normal-appearing mucosa allows for the harvesting of 5 or more salivary gland lobules.
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Biopsy of the minor salivary glands of the lower ...

Biopsy of the minor salivary glands of the lower lip may be useful in the diagnosis of Sjögren syndrome. A 1.5- to 2-cm incision of normal-appearing mucosa allows for the harvesting of 5 or more salivary gland lobules.

Low-power photomicrograph of a minor salivary gla...
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Media file 8: Low-power photomicrograph of a minor salivary gland lobule showing multiple lymphocytic foci that are replacing the acinar structures (hematoxylin-eosin, 40 X).
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Low-power photomicrograph of a minor salivary gla...

Low-power photomicrograph of a minor salivary gland lobule showing multiple lymphocytic foci that are replacing the acinar structures (hematoxylin-eosin, 40 X).

Intermediate-power photomicrograph demonstrating ...
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Media file 9: Intermediate-power photomicrograph demonstrating a chronic inflammatory aggregate of more than 50 lymphocytes and plasma cells with a periductal pattern. The inflammatory focus is adjacent to normal appearing acini (hematoxylin-eosin, 200 X).
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Intermediate-power photomicrograph demonstrating ...

Intermediate-power photomicrograph demonstrating a chronic inflammatory aggregate of more than 50 lymphocytes and plasma cells with a periductal pattern. The inflammatory focus is adjacent to normal appearing acini (hematoxylin-eosin, 200 X).

High-power photomicrograph of the chronic inflamm...
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Media file 10: High-power photomicrograph of the chronic inflammatory aggregate consists of lymphocytes and plasma cells around a ductal structure (hematoxylin-eosin, 400 X).
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High-power photomicrograph of the chronic inflamm...

High-power photomicrograph of the chronic inflammatory aggregate consists of lymphocytes and plasma cells around a ductal structure (hematoxylin-eosin, 400 X).

More on Sjogren Syndrome

Overview: Sjogren Syndrome
Differential Diagnoses & Workup: Sjogren Syndrome
Treatment & Medication: Sjogren Syndrome
Follow-up: Sjogren Syndrome
Multimedia: Sjogren Syndrome
References
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Further Reading

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Keywords

Sjogren syndrome, Sjögren's syndrome, Sjögren syndrome, Sicca syndrome, keratoconjunctivitis, xerostomia, polyarthritis, parotitis, salivary gland enlargement, recurrent parotitis, autoimmune exocrinopathy, systemic lupus erythematosus, SLE, rheumatoid arthritis, scleroderma, biliary cirrhosis, lymphoproliferative disease, non-Hodgkin lymphoma, Waldenström macroglobulinemia, B-cell lymphoma, keratoconjunctivitis, Raynaud phenomenon, Epstein-Barr virus, EBV, HIV, cytomegalovirus, treatment, diagnosis

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Contributor Information and Disclosures

Author

Eyal Muscal, MD, Assistant Professor, Section of Pediatric Rheumatology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital
Eyal Muscal, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Rheumatology, and Clinical Immunology Society
Disclosure: Nothing to disclose.

Coauthor(s)

Marietta Morales de Guzman, MD, Assistant Professor, Department of Pediatrics, Baylor College of Medicine; Consulting Staff, Section of Pediatric Rheumatology, Department of Pediatrics, Texas Children's Hospital, Ben Taub General Hospital
Marietta Morales de Guzman, MD is a member of the following medical societies: American Academy of Pediatrics, American College of Rheumatology, and Texas Pediatric Society
Disclosure: Nothing to disclose.

Lawrence K Jung, MD, Chief, Division of Pediatric Rheumatology, Children's National Medical Center
Lawrence K Jung, MD is a member of the following medical societies: American Association for the Advancement of Science, American Association of Immunologists, American College of Rheumatology, Clinical Immunology Society, and New York Academy of Sciences
Disclosure: Nothing to disclose.

Catherine M Flaitz, DDS, MS, Professor of Oral and Maxillofacial Pathology and Pediatric Dentistry, Department of Diagnostic Sciences, University of Texas Health Sciences Center at Houston, Dental Branch
Catherine M Flaitz, DDS, MS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, American Academy of Oral Medicine, American Academy of Pediatric Dentistry, American Dental Association, International Association for Dental Research, and International Association of Oral Pathologists
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

David D Sherry, MD, Director, Clinical Rheumatology, Attending Physician, Pain Management, The Children's Hospital of Philadelphia; Professor of Pediatrics, University of Pennsylvania
David D Sherry, MD is a member of the following medical societies: American College of Rheumatology and American Pain Society
Disclosure: Nothing to disclose.

CME Editor

Daniel Rauch, MD, FAAP, Director, Pediatric Hospitalist Program, Associate Professor, Department of Pediatrics, New York University School of Medicine
Daniel Rauch, MD, FAAP is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Society of Hospital Medicine
Disclosure: Baxter Honoraria Consulting

 
 
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