Toxicity, Isoniazid: Multimedia

References

1. Agrawal RL, Dwivedi NC, Agrawal M, Jain S, Agrawal A. Accidental isoniazid poisoning--a report. Indian J Tuberc. Apr 2008;55(2):94-6. [Medline].

2. Tostmann A, Boeree MJ, Peters WH, et al. Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity. Int J Antimicrob Agents. Jun 2008;31(6):577-80. [Medline].

3. Taylor Z, Nolan CM, Blumberg HM. Controlling tuberculosis in the United States. Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America. MMWR Recomm Rep. Nov 4 2005;54:1-81. [Medline].

4. Litovitz TL, Schmitz BF, Bailey KM. 1989 annual report of the American Association of Poison Control Centers National Data Collection System. Am J Emerg Med. Sep 1990;8(5):394-442. [Medline].

5. Litovitz TL, Bailey KM, Schmitz BF, Holm KC, Klein-Schwartz W. 1990 annual report of the American Association of Poison Control Centers National Data Collection System. Am J Emerg Med. Sep 1991;9(5):461-509. [Medline].

6. Litovitz TL, Holm KC, Bailey KM, Schmitz BF. 1991 annual report of the American Association of Poison Control Centers National Data Collection System. Am J Emerg Med. Sep 1992;10(5):452-505. [Medline].

7. Litovitz TL, Holm KC, Clancy C, Schmitz BF, Clark LR, Oderda GM. 1992 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1993;11(5):494-555. [Medline].

8. Litovitz TL, Clark LR, Soloway RA. 1993 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1994;12(5):546-84. [Medline].

9. Litovitz TL, Felberg L, Soloway RA, Ford M, Geller R. 1994 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1995;13(5):551-97. [Medline].

10. Litovitz TL, Felberg L, White S, Klein-Schwartz W. 1995 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1996;14(5):487-537. [Medline].

11. Litovitz TL, Smilkstein M, Felberg L, Klein-Schwartz W, Berlin R, Morgan JL. 1996 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1997;15(5):447-500. [Medline].

12. Litovitz TL, Klein-Schwartz W, Dyer KS, Shannon M, Lee S, Powers M. 1997 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1998;16(5):443-97. [Medline].

13. Kalaci A, Duru M, Karazincir S, Sevinc TT, Kuvandik G, Balci A. Thoracic spine compression fracture during isoniazid-induced seizures: case report. Pediatr Emerg Care. Dec 2008;24(12):842-4. [Medline].

14. Santucci KA, Shah BR, Linakis JG. Acute isoniazid exposures and antidote availability. Pediatr Emerg Care. Apr 1999;15(2):99-101. [Medline].

15. Albin RL, Albers JW, Greenberg HS, et al. Acute sensory neuropathy-neuronopathy from pyridoxine overdose. Neurology. Nov 1987;37(11):1729-32. [Medline].

16. Alvarez FG, Guntupalli KK. Isoniazid overdose: four case reports and review of the literature. Intensive Care Med. Aug 1995;21(8):641-4. [Medline].

17. Black LE, Ros SP. Complete recovery from severe metabolic acidosis associated with isoniazid poisoning in a young boy. Pediatr Emerg Care. Dec 1989;5(4):257-8. [Medline].

18. Blanchard PD, Yao JD, McAlpine DE, Hurt RD. Isoniazid overdose in the Cambodian population of Olmsted County, Minnesota. JAMA. Dec 12 1986;256(22):3131-3. [Medline].

19. Blowey DL, Johnson D, Verjee Z. Isoniazid-associated rhabdomyolysis. Am J Emerg Med. Sep 1995;13(5):543-4. [Medline].

20. Bredemann JA, Krechel SW, Eggers GW Jr. Treatment of refractory seizures in massive isoniazid overdose. Anesth Analg. Nov 1990;71(5):554-7. [Medline].

21. Caksen H, Odabas D, Erol M, Anlar O, Tuncer O, Atas B. Do not overlook acute isoniazid poisoning in children with status epilepticus. J Child Neurol. Feb 2003;18(2):142-3. [Medline].

22. Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. Feb 2005;33(2):427-36. [Medline].

23. Goldman AL, Braman SS. Isoniazid: a review with emphasis on adverse effects. Chest. Jul 1972;62(1):71-7. [Medline].

24. Knapp JF, Johnson T, Alander S. Seizures in a 13-year-old girl. Pediatr Emerg Care. Feb 2003;19(1):38-40. [Medline].

25. Kursad H, Kizilkaya M, Sahin M, Dogan N, Ilgaz A. Treatment of acute isoniazid toxicity of unknown dose. South Med J. Jan 2003;96(1):101. [Medline].

26. Lheureux P, Penaloza A, Gris M. Pyridoxine in clinical toxicology: a review. Eur J Emerg Med. Apr 2005;12(2):78-85. [Medline].

27. Litovitz TL, Klein-Schwartz W, Caravati EM, Youniss J, Crouch B, Lee S. 1998 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. Sep 1999;17(5):435-87. [Medline].

28. McLay RN, Drake A, Rayner T. Persisting dementia after isoniazid overdose. J Neuropsychiatry Clin Neurosci. Spring 2005;17(2):256-7. [Medline].

29. Miller J, Robinson A, Percy AK. Acute isoniazid poisoning in childhood. Am J Dis Child. Mar 1980;134(3):290-2. [Medline].

30. Morrow LE, Wear RE, Schuller D, Malesker M. Acute isoniazid toxicity and the need for adequate pyridoxine supplies. Pharmacotherapy. Oct 2006;26(10):1529-32. [Medline].

31. Nolan CM, Elarth AM, Barr HW. Intentional isoniazid overdosage in young Southeast Asian refugee women. Chest. Apr 1988;93(4):803-6. [Medline].

32. Osborn H. LR Goldfrank, NE Flomenbaum, NA Lewin, RS Weisman, MA Howland, RS Hoffman, eds. Antituberculous Agents. Goldfrank's Toxicologic Emergencies; 1998:727-740.

33. Scolding N, Ward MJ, Hutchings A, Routledge PA. Charcoal and isoniazid pharmacokinetics. Hum Toxicol. Jul 1986;5(4):285-6. [Medline].

34. Shah BR, Santucci K, Sinert R, Steiner P. Acute isoniazid neurotoxicity in an urban hospital. Pediatrics. May 1995;95(5):700-4. [Medline].

35. Siefkin AD, Albertson TE, Corbett MG. Isoniazid overdose: pharmacokinetics and effects of oral charcoal in treatment. Hum Toxicol. Nov 1987;6(6):497-501. [Medline].

36. Tibussek D, Mayatepek E, Distelmaier F, Rosenbaum T. Status epilepticus due to attempted suicide with isoniazid. Eur J Pediatr. Feb 2006;165(2):136-7. [Medline].

37. Topcu I, Yentur EA, Kefi A, Ekici NZ, Sakarya M. Seizures, metabolic acidosis and coma resulting from acute isoniazid intoxication. Anaesth Intensive Care. Aug 2005;33(4):518-20. [Medline].

38. Wills B, Erickson T. Drug- and toxin-associated seizures. Med Clin North Am. Nov 2005;89(6):1297-321. [Medline].

Further Reading

Keywords

isoniazid, INH, INH toxicity, isoniazid poisoning, isonicotinic acid hydrazide, isoniazid-induced seizure, isoniazid seizure, tuberculosis, TB, overdose, seizure, tonic-clonic seizure, metabolic acidosis, treatment, diagnosis, hypotension, stupor tremor, mydriasis, urinary retention, ataxia, areflexia, nystagmus

Contributor Information and Disclosures

Author

David Tran, MD, Attending Physician, Department of Emergency Medicine, North Shore-LIJ Plainview Hospital
David Tran, MD is a member of the following medical societies: American Academy of Emergency Medicine and American College of Emergency Physicians
Disclosure: Nothing to disclose.

Coauthor(s)

Binita R Shah, MD, FAAP, Professor of Clinical Pediatrics and Emergency Medicine, SUNY Health Sciences Center at Brooklyn; Director of Pediatric Emergency Medicine, Departments of Emergency Medicine and Pediatrics, Kings County Hospital Center
Binita R Shah, MD, FAAP is a member of the following medical societies: American Academy of Pediatrics
Disclosure: Nothing to disclose.

Medical Editor

William T Zempsky, MD, Associate Director, Assistant Professor, Department of Pediatrics, Division of Pediatric Emergency Medicine, University of Connecticut and Connecticut Children's Medical Center
William T Zempsky, MD is a member of the following medical societies: American Academy of Pediatrics
Disclosure: Nothing to disclose.

Pharmacy Editor

Mary L Windle, PharmD, Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy, Pharmacy Editor, eMedicine
Disclosure: Pfizer Inc Stock Investment from financial planner; Avanir Pharma Stock Investment from financial planner ; WebMD Salary and stock Employment and investment from financial planner

Managing Editor

Jeffrey R Tucker, MD, Assistant Professor, Department of Pediatrics, Division of Emergency Medicine, University of Connecticut and Connecticut Children's Medical Center
Jeffrey R Tucker, MD is a member of the following medical societies: American Academy of Clinical Toxicology, American Academy of Pediatrics, and Massachusetts Medical Society
Disclosure: Merck Salary Employment

CME Editor

Daniel Rauch, MD, FAAP, Director, Pediatric Hospitalist Program, Associate Professor, Department of Pediatrics, New York University School of Medicine
Daniel Rauch, MD, FAAP is a member of the following medical societies: Ambulatory Pediatric Association, American Academy of Pediatrics, and Society of Hospital Medicine
Disclosure: Baxter Honoraria Consulting

Chief Editor

Timothy E Corden, MD, Associate Professor of Pediatrics, Co-Director, Policy Core, Injury Research Center, Medical College of Wisconsin; Associate Director, PICU, Children's Hospital of Wisconsin
Timothy E Corden, MD is a member of the following medical societies: American Academy of Pediatrics, Phi Beta Kappa, Society of Critical Care Medicine, and Wisconsin Medical Society
Disclosure: Nothing to disclose.