Pediatric Monoamine Oxidase Inhibitor Toxicity Treatment & Management
- Author: Soumya Ganapathy, MD; Chief Editor: Timothy E Corden, MD more...
As with most toxic ingestions, the cornerstone of management is continuous monitoring, decontamination when clinically indicated, and meticulous supportive care.
- Give careful attention to airway management.
- Maintain euvolemia because patients with monoamine oxidase inhibitor (MAOI) poisoning can become dehydrated secondary to their hypermetabolic state.
- Maintain euthermia, especially in patients with suspected serotonin syndrome. Water mist sprays with fanning are effective. The removal of clothing and the use of cooling blankets may also be effective.
- Treat seizures and agitation with intravenous benzodiazepines.
- Decontamination with activated charcoal should be performed with caution and with attention to the possibility of airway compromise.
- Treat hypertension only if it is sustained and clinically significant.
See the list below:
- Close consultation with a medical toxicologist or personnel from a regional poison center is recommended.
- Consult a pediatric intensivist.
- Consult a psychiatrist in cases of suspected intentional ingestion.
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