eMedicine Specialties > Dermatology > Allergy & Immunology
Drug Eruptions: Multimedia
Updated: Jan 5, 2009
Multimedia
![]() | Media file 1: Morbilliform drug eruption. |
![]() | Media file 2: Warfarin (Coumadin) necrosis involving the leg. |
![]() | Media file 3: Toxic epidermal necrolysis. |
![]() | Media file 4: Stevens-Johnson syndrome. |
![]() | Media file 5: Erythroderma. |
![]() | Media file 6: Erythema multiforme. |
![]() | Media file 7: Fixed drug eruption. |
![]() | Media file 8: Fixed drug eruption involving the penis. |
![]() | Media file 9: Oral ulcerations in a patient receiving cytotoxic therapy. |
![]() | Media file 10: Phototoxic reaction after use of a tanning booth. Note sharp cutoff where clothing blocked exposure. |
![]() | Media file 11: Vasculitic reaction on the legs. |
![]() | Media file 12: Lichen planus on the neck. |
![]() | Media file 13: Steroid acne. Note pustules and absence of comedones. |
![]() | Media file 14: Drug reaction to hydroxychloroquine (Plaquenil). |
![]() | Media file 15: Urticaria. |
![]() | Media file 16: Erythema nodosum. |
![]() | Media file 17: Confluent necrosis of the epidermis in toxic epidermal necrolysis. |
![]() | Media file 18: Perivascular mixed inflammatory infiltrate with eosinophils characteristic of drug-induced urticaria. |
![]() | Media file 19: Biopsy of pseudoporphyria shows a subepidermal blister with little to no inflammation. |
![]() | Media file 20: Confluent necrosis of the epidermis in toxic epidermal necrolysis. |
![]() | Media file 21: Superficial perivascular inflammatory infiltrate with numerous eosinophils characteristic of an exanthematous drug eruption. |
![]() | Media file 22: Target lesions of erythema multiforme. |
More on Drug Eruptions |
| Overview: Drug Eruptions |
| Differential Diagnoses & Workup: Drug Eruptions |
| Treatment & Medication: Drug Eruptions |
| Follow-up: Drug Eruptions |
Multimedia: Drug Eruptions |
| References |
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References
Iannini P, Mandell L, Felmingham J, Patou G, Tillotson GS. Adverse cutaneous reactions and drugs: a focus on antimicrobials. J Chemother. Apr 2006;18(2):127-39. [Medline].
Green JJ, Manders SM. Pseudoporphyria. J Am Acad Dermatol. Jan 2001;44(1):100-8. [Medline].
Coopman SA, Johnson RA, Platt R, Stern RS. Cutaneous disease and drug reactions in HIV infection. N Engl J Med. Jun 10 1993;328(23):1670-4. [Medline].
Dacey MJ, Callen JP. Hydroxyurea-induced dermatomyositis-like eruption. J Am Acad Dermatol. Mar 2003;48(3):439-41. [Medline].
Ellgehausen P, Elsner P, Burg G. Drug-induced lichen planus. Clin Dermatol. May-Jun 1998;16(3):325-32. [Medline].
Camilleri M, Pace JL. Drug-induced linear immunoglobulin-A bullous dermatosis. Clin Dermatol. May-Jun 1998;16(3):389-91. [Medline].
Antonov D, Kazandjieva J, Etugov D, Gospodinov D, Tsankov N. Drug-induced lupus erythematosus. Clin Dermatol. Mar-Apr 2004;22(2):157-66. [Medline].
Brenner S, Bialy-Golan A, Ruocco V. Drug-induced pemphigus. Clin Dermatol. May-Jun 1998;16(3):393-7. [Medline].
Brauchli YB, Jick SS, Curtin F, Meier CR. Association between beta-blockers, other antihypertensive drugs and psoriasis: population-based case-control study. Br J Dermatol. Jun 2008;158(6):1299-307. [Medline].
Dika E, Varotti C, Bardazzi F, Maibach HI. Drug-induced psoriasis: an evidence-based overview and the introduction of psoriatic drug eruption probability score. Cutan Ocul Toxicol. 2006;25(1):1-11. [Medline].
Tsankov N, Angelova I, Kazandjieva J. Drug-induced psoriasis. Recognition and management. Am J Clin Dermatol. May-Jun 2000;1(3):159-65. [Medline].
Clark BM, Kotti GH, Shah AD, Conger NG. Severe serum sickness reaction to oral and intramuscular penicillin. Pharmacotherapy. May 2006;26(5):705-8. [Medline].
Hazin R, Ibrahimi OA, Hazin MI, Kimyai-Asadi A. Stevens-Johnson syndrome: pathogenesis, diagnosis, and management. Ann Med. 2008;40(2):129-38. [Medline].
Lee HY, Pang SM, Thamotharampillai T. Allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. J Am Acad Dermatol. Aug 2008;59(2):352-3. [Medline].
Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. Dec 14 1995;333(24):1600-7. [Medline].
MacMorran WS, Krahn LE. Adverse cutaneous reactions to psychotropic drugs. Psychosomatics. Sep-Oct 1997;38(5):413-22. [Medline].
Roe E, Garcia Muret MP, Marcuello E, Capdevila J, Pallares C, Alomar A. Description and management of cutaneous side effects during cetuximab or erlotinib treatments: a prospective study of 30 patients. J Am Acad Dermatol. Sep 2006;55(3):429-37. [Medline].
Shipley D, Ormerod AD. Drug-induced urticaria. Recognition and treatment. Am J Clin Dermatol. 2001;2(3):151-8. [Medline].
Asnis LA, Gaspari AA. Cutaneous reactions to recombinant cytokine therapy. J Am Acad Dermatol. Sep 1995;33(3):393-410; quiz 410-2. [Medline].
Barbaud A. Drug patch testing in systemic cutaneous drug allergy. Toxicology. Apr 15 2005;209(2):209-16. [Medline].
French LE, Trent JT, Kerdel FA. Use of intravenous immunoglobulin in toxic epidermal necrolysis and Stevens-Johnson syndrome: our current understanding. Int Immunopharmacol. Apr 2006;6(4):543-9. [Medline].
Mukasa Y, Craven N. Management of toxic epidermal necrolysis and related syndromes. Postgrad Med J. Feb 2008;84(988):60-5. [Medline].
Paquet P, Piérard GE, Quatresooz P. Novel treatments for drug-induced toxic epidermal necrolysis (Lyell's syndrome). Int Arch Allergy Immunol. Mar 2005;136(3):205-16. [Medline].
Bork K. Adverse drug reactions. In: Demis DJ, ed. Clinical Dermatology. Vol 3. Philadelphia, Pa: Lippincott-Raven; 1998.
Breathnach SM, Hintner H. Adverse Drug Reactions and the Skin. London, England: Blackwell Scientific; 1992.
Campos-Fernandez Mdel M, Ponce-De-Leon-Rosales S, Archer-Dubon C, Orozco-Topete R. Incidence and risk factors for cutaneous adverse drug reactions in an intensive care unit. Rev Invest Clin. Nov-Dec 2005;57(6):770-4. [Medline].
Coombs RRA, Gell PGH. Classification of allergic reactions responsible for clinical hypersensitivity and disease. Clin Aspects Immunol. 1968;575-96.
Daoud MS, Schanbacher CF, Dicken CH. Recognizing cutaneous drug eruptions. Reaction patterns provide clues to causes. Postgrad Med. Jul 1998;104(1):101-4, 107-8, 114-5. [Medline].
Fitzpatrick JE. New histopathologic findings in drug eruptions. Dermatol Clin. Jan 1992;10(1):19-36. [Medline].
Greenberger PA. 8. Drug allergy. J Allergy Clin Immunol. Feb 2006;117(2 Suppl Mini-Primer):S464-70. [Medline].
Heidary N, Naik H, Burgin S. Chemotherapeutic agents and the skin: An update. J Am Acad Dermatol. Apr 2008;58(4):545-70. [Medline].
Hunziker T, Kunzi UP, Braunschweig S, Zehnder D, Hoigne R. Comprehensive hospital drug monitoring (CHDM): adverse skin reactions, a 20-year survey. Allergy. Apr 1997;52(4):388-93. [Medline].
Keet I, Meyaard L, Boucher E, et al. Allergic reactions to cotrimoxazole correlate with decreased T-cell reactivity compatible with a Th1 to Th2 shift [abstr PO-A19-0404]. Int Conf AIDS. 1993;9 (1):202.
Kramer MS, Leventhal JM, Hutchinson TA, Feinstein AR. An algorithm for the operational assessment of adverse drug reactions. I. Background, description, and instructions for use. JAMA. Aug 17 1979;242(7):623-32. [Medline].
Lerch M, Pichler WJ. The immunological and clinical spectrum of delayed drug-induced exanthems. Curr Opin Allergy Clin Immunol. Oct 2004;4(5):411-9. [Medline].
Litt JZ. Drug Eruption Reference Manual 2002. New York, NY: Parthenon; 2002.
Mayorga C, Pena RR, Blanca-Lopez N, Lopez S, Martin E, Torres MJ. Monitoring the acute phase response in non-immediate allergic drug reactions. Curr Opin Allergy Clin Immunol. Aug 2006;6(4):249-57. [Medline].
McKenna JK, Leiferman KM. Dermatologic drug reactions. Immunol Allergy Clin North Am. Aug 2004;24(3):399-423, vi. [Medline].
Mockenhaupt M, Schopf E. Epidemiology of drug-induced severe skin reactions. Semin Cutan Med Surg. Dec 1996;15(4):236-43. [Medline].
Nigen S, Knowles SR, Shear NH. Drug eruptions: approaching the diagnosis of drug-induced skin diseases. J Drugs Dermatol. Jun 2003;2(3):278-99. [Medline].
Pereira FA, Mudgil AV, Rosmarin DM. Toxic epidermal necrolysis. J Am Acad Dermatol. Feb 2007;56(2):181-200. [Medline].
Revuz J, Valeyrie-Allanore L. Drug reactions. In: Dermatology. Vol 1. Philadelphia, Pa: Mosby; 2003:333-53.
Roujeau JC, Bioulac-Sage P, Bourseau C, Guillaume JC, Bernard P, Lok C, et al. Acute generalized exanthematous pustulosis. Analysis of 63 cases. Arch Dermatol. Sep 1991;127(9):1333-8. [Medline].
Sahin S, Comert A, Akin O, Ayalp S, Karsidag S. Cutaneous drug eruptions by current antiepileptics: case reports and alternative treatment options. Clin Neuropharmacol. Mar-Apr 2008;31(2):93-6. [Medline].
Shapiro LE, Shear NH. Mechanisms of drug reactions: the metabolic track. Semin Cutan Med Surg. Dec 1996;15(4):217-27. [Medline].
Stern RS, Steinberg LA. Epidemiology of adverse cutaneous reactions to drugs. Dermatol Clin. Jul 1995;13(3):681-8. [Medline].
Susser WS, Whitaker-Worth DL, Grant-Kels JM. Mucocutaneous reactions to chemotherapy. J Am Acad Dermatol. Mar 1999;40(3):367-98; quiz 399-400. [Medline].
Ward HA, Russo GG, Shrum J. Cutaneous manifestations of antiretroviral therapy. J Am Acad Dermatol. Feb 2002;46(2):284-93. [Medline].
Warnock JK, Morris DW. Adverse cutaneous reactions to antidepressants. Am J Clin Dermatol. 2002;3(5):329-39. [Medline].
Warnock JK, Morris DW. Adverse cutaneous reactions to mood stabilizers. Am J Clin Dermatol. 2003;4(1):21-30. [Medline].
Wolf R, Orion E, Marcos B, Matz H. Life-threatening acute adverse cutaneous drug reactions. Clin Dermatol. Mar-Apr 2005;23(2):171-81. [Medline].
Wolverton SE. Update on cutaneous drug reactions. Adv Dermatol. 1997;13:65-84. [Medline].
Wyatt AJ, Leonard GD, Sachs DL. Cutaneous reactions to chemotherapy and their management. Am J Clin Dermatol. 2006;7(1):45-63. [Medline].
Further Reading
Keywords
adverse cutaneous drug reactions, cutaneous reaction to drugs, drug-induced cutaneous reactions, mucocutaneous drug reactions, dermatoses, dermatosis, cutaneous eruptions, cutaneous drug reactions, adverse drug reactions, drug allergy, fixed drug reactions, medication adverse effects, medication side effects, adverse effects, side effects, medication allergy












































Multimedia: Drug Eruptions