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Dermatologic Manifestations of Job Syndrome Differential Diagnoses

  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Jun 09, 2016
 
 

Diagnostic Considerations

Differentiation from other disorders associated with eczema and increased serum IgE levels, such as other primary immunodeficiencies and atopic dermatitis, can be challenging.[33, 34, 15]

Chronic granulomatous disease with markedly elevated IgE levels may mimic hyperimmunoglobulin E syndrome.[35] However, tuberculosis may be associated with Job syndrome and may be first evident as miliary tuberculosis.[36]

The relevance of eosinophilia and hyper-IgE in immigrant children from Africa and Latin America has been explored. The prevalence and causes of eosinophilia and hyper-IgE in 362 immigrant children in Spain was prospectively evaluated, with the most frequent causes of absolute eosinophilia being filariasis (52.6%), strongyloidiasis (46.8%), and schistosomiasis (28.9%) and the most frequent causes of increased levels of IgE being filariasis (41.9%), strongyloidiasis (29.6%), and schistosomiasis (22.2%).[37] Thus, eosinophilia and hyper-IgE are important biomarkers of helminthiasis in children coming from tropical and subtropical areas.

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs and Administration

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, New York Academy of Medicine, American Academy of Dermatology, American College of Physicians, Sigma Xi

Disclosure: Nothing to disclose.

Coauthor(s)

Mordechai M Tarlow, MD Clinical Assistant Professor of Dermatology, University of Pennsylvania School of Medicine

Mordechai M Tarlow, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society for MOHS Surgery, American College of Aesthetic and Cosmetic Physicians; American Society of Aesthetic/Cosmetic Physicians, American Medical Association, Sigma Xi

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Jeffrey J Miller, MD Associate Professor of Dermatology, Pennsylvania State University College of Medicine; Staff Dermatologist, Pennsylvania State Milton S Hershey Medical Center

Jeffrey J Miller, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, Society for Investigative Dermatology, Association of Professors of Dermatology, North American Hair Research Society

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

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