Granuloma Inguinale (Donovanosis) Medication
- Author: Elizabeth K Satter, MD, MPH; Chief Editor: Dirk M Elston, MD more...
The goal of pharmacotherapy for granuloma inguinale is to reduce morbidity and to prevent complications.
Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the clinical setting.
Sulfamethoxazole inhibits the bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase and blocks the production of tetrahydrofolic acid from dihydrofolic acid.
Doxycycline is a bacteriostatic tetracycline antibiotic that inhibits protein synthesis and thus bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria.
Ciprofloxacin is a bactericidal fluoroquinolone antibiotic that inhibits the bacterial enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunits of susceptible organisms; it may be bacteriocidal or bacteriostatic depending on the concentration and type of microorganism.
Azithromycin is an azalide antibiotic (subclass of macrolide antibiotics) that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunits of susceptible organisms; it may be bacteriocidal or bacteriostatic depending on the concentration and type of microorganism.
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