eMedicine Specialties > Dermatology > Bacterial Infections
Necrotizing Fasciitis: Follow-up
Updated: May 5, 2009
Follow-up
Complications
- Sepsis and renal failure are possible complications of necrotizing fasciitis.
- Metastatic cutaneous plaques may occur.
- Septicemia is typical and leads to severe systemic toxicity and rapid death unless appropriately treated.
Prognosis
- The poor prognosis in necrotizing fasciitis has been linked to infection with certain streptococcal strains.
- The mortality rate can be as high as 25%.
- Aeromonas infection, Vibrio infection, cancer, hypotension, and band form WBC count greater than 10% were found to be independent positive predictors of mortality in patients with necrotizing fasciitis, while streptococcal and staphylococcal infections were not identified as predictors of mortality. Hemorrhagic bullae appeared to be an independent negative predictor of mortality. However, accuracy of these factors needs to be verified.27
Miscellaneous
Medicolegal Pitfalls
- Missing this diagnosis may prove fatal for the patient and lead to obvious medicolegal repercussions for his or her health care providers.
More on Necrotizing Fasciitis |
| Overview: Necrotizing Fasciitis |
| Differential Diagnoses & Workup: Necrotizing Fasciitis |
| Treatment & Medication: Necrotizing Fasciitis |
Follow-up: Necrotizing Fasciitis |
| Multimedia: Necrotizing Fasciitis |
| References |
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References
Kihiczak GG, Schwartz RA, Kapila R. Necrotizing fasciitis: a deadly infection. J Eur Acad Dermatol Venereol. Apr 2006;20(4):365-9. [Medline].
Federman DG, Kravetz JD, Kirsner RS. Necrotizing fasciitis and cardiac catheterization. Cutis. Jan 2004;73(1):49-52. [Medline].
Akcay EK, Cagil N, Yulek F, et al. Necrotizing fasciitis of eyelid secondary to parotitis. Eur J Ophthalmol. Jan-Feb 2008;18(1):128-30. [Medline].
Anwar UM, Ahmad M, Sharpe DT. Necrotizing Fasciitis After Liposculpture. Aesthetic Plast Surg. 12 2 2004;[Medline].
Bisno AL, Cockerill FR 3rd, Bermudez CT. The initial outpatient-physician encounter in group A streptococcal necrotizing fasciitis. Clin Infect Dis. Aug 2000;31(2):607-8. [Medline].
Gibbon KL, Bewley AP. Acquired streptococcal necrotizing fasciitis following excision of malignant melanoma. Br J Dermatol. Oct 1999;141(4):717-9. [Medline].
Sewell GS, Hsu VP, Jones SR. Zoster gangrenosum: necrotizing fasciitis as a complication of herpes zoster. Am J Med. Apr 15 2000;108(6):520-1. [Medline].
Tung-Yiu W, Jehn-Shyun H, Ching-Hung C, Hung-An C. Cervical necrotizing fasciitis of odontogenic origin: a report of 11 cases. J Oral Maxillofac Surg. Dec 2000;58(12):1347-52; discussion 1353. [Medline].
Morgan WR, Caldwell MD, Brady JM. Necrotizing fasciitis due to a methicillin-sensitive Staphylococcus aureus isolate harboring an enterotoxin gene cluster. J Clin Microbiol. Feb 2007;45(2):668-71. [Medline].
Cheng NC, Chang SC, Kuo YS, Wang JL, Tang YB. Necrotizing fasciitis caused by methicillin-resistant Staphylococcus aureus resulting in death. A report of three cases. J Bone Joint Surg Am. May 2006;88(5):1107-10. [Medline].
Fustes-Morales A, Gutierrez-Castrellon P, Duran-Mckinster C, Orozco-Covarrubias L, Tamayo-Sanchez L, Ruiz-Maldonado R. Necrotizing fasciitis: report of 39 pediatric cases. Arch Dermatol. Jul 2002;138(7):893-9. [Medline].
Ford LM, Waksman J. Necrotizing fasciitis during primary varicella. Pediatrics. Jun 2000;105(6):1372-3; discussion 1373-5. [Medline].
Dahm P, Roland FH, Vaslef SN, et al. Outcome analysis in patients with primary necrotizing fasciitis of the male genitalia. Urology. Jul 2000;56(1):31-5; discussion 35-6. [Medline].
Iwata Y, Sato S, Murase Y, et al. Five cases of necrotizing fasciitis: lack of skin inflammatory signs as a clinical clue for the fulminant type. J Dermatol. Nov 2008;35(11):719-25. [Medline].
Zahar JR, Goveia J, Lesprit P, Brun-Buisson C. Severe soft tissue infections of the extremities in patients admitted to an intensive care unit. Clin Microbiol Infect. Jan 2005;11(1):79-82. [Medline].
Tang WM, Ho PL, Yau WP, Wong JW, Yip DK. Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. Clin Infect Dis. Oct 2000;31(4):E15-7. [Medline].
Sendi P, Johansson L, Dahesh S, et al. Bacterial phenotype variants in group B streptococcal toxic shock syndrome. Emerg Infect Dis. Feb 2009;15(2):223-32. [Medline].
Dawar M, Russell B, McClean K, Levett PN, Tyrrell GJ, Irvine J. A case of necrotizing fasciitis due to Streptococcus pneumoniae serotype 5 in Saskatchewan. Can J Infect Dis Med Microbiol. Jan 2008;19(1):69-71. [Medline].
Tang WM, Fung KK, Cheng VC, Lucke L. Rapidly progressive necrotising fasciitis following a stonefish sting: a report of two cases. J Orthop Surg (Hong Kong). Apr 2006;14(1):67-70. [Medline].
Simonart T, Simonart JM, Derdelinckx I, et al. Value of standard laboratory tests for the early recognition of group A beta-hemolytic streptococcal necrotizing fasciitis. Clin Infect Dis. Jan 2001;32(1):E9-12. [Medline].
Arslan A, Pierre-Jerome C, Borthne A. Necrotizing fasciitis: unreliable MRI findings in the preoperative diagnosis. Eur J Radiol. Dec 2000;36(3):139-43. [Medline].
Ramirez-Schrempp D, Dorfman DH, Baker WE, Liteplo AS. Ultrasound soft tissue applications in the pediatric emergency department: to drain or not to drain?. Pediatr Emerg Care. Jan 2009;25(1):44-8. [Medline].
Bakleh M, Wold LE, Mandrekar JN, Harmsen WS, Dimashkieh HH, Baddour LM. Correlation of histopathologic findings with clinical outcome in necrotizing fasciitis. Clin Infect Dis. Feb 1 2005;40(3):410-4. [Medline].
Korhonen K. Hyperbaric oxygen therapy in acute necrotizing infections with a special reference to the effects on tissue gas tensions. Ann Chir Gynaecol Suppl. 2000;(214):7-36. [Medline].
Korhonen K, Kuttila K, Niinikoski J. Tissue gas tensions in patients with necrotising fasciitis and healthy controls during treatment with hyperbaric oxygen: a clinical study. Eur J Surg. Jul 2000;166(7):530-4. [Medline].
Krenk L, Nielsen HU, Christensen ME. Necrotizing fasciitis in the head and neck region: an analysis of standard treatment effectiveness. Eur Arch Otorhinolaryngol. Mar 6 2007;[Medline].
Hsiao CT, Weng HH, Yuan YD, Chen CT, Chen IC. Predictors of mortality in patients with necrotizing fasciitis. Am J Emerg Med. Feb 2008;26(2):170-5. [Medline].
Afifi RY, El-Hindawi AA. Acute necrotizing fasciitis in Egyptian patients. Int J Surg. Jan 28 2008;[Medline].
Brandt MM, Corpron CA, Wahl WL. Necrotizing soft tissue infections: a surgical disease. Am Surg. Oct 2000;66(10):967-70; discussion 970-1. [Medline].
Chan HT, Low J, Wilson L, Harris OC, Cheng AC, Athan E. Case cluster of necrotizing fasciitis and cellulitis associated with vein sclerotherapy. Emerg Infect Dis. Jan 2008;14(1):180-1. [Medline].
Cox NH. Streptococcal necrotizing fasciitis and the dermatologist. Br J Dermatol. Oct 1999;141(4):613-4. [Medline].
Elliott D, Kufera JA, Myers RA. The microbiology of necrotizing soft tissue infections. Am J Surg. May 2000;179(5):361-6. [Medline].
Hassell M, Fagan P, Carson P, Currie BJ. Streptococcal necrotising fasciitis from diverse strains of Streptococcus pyogenes in tropical northern Australia: case series and comparison with the literature. BMC Infect Dis. Dec 16 2004;4(1):60. [Medline].
Hsieh T, Samson LM, Jabbour M, Osmond MH. Necrotizing fasciitis in children in eastern Ontario: a case-control study. CMAJ. Aug 22 2000;163(4):393-6. [Medline].
Urschel JD. Necrotizing soft tissue infections. Postgrad Med J. Nov 1999;75(889):645-9. [Medline].
Wall DB, de Virgilio C, Black S, Klein SR. Objective criteria may assist in distinguishing necrotizing fasciitis from nonnecrotizing soft tissue infection. Am J Surg. Jan 2000;179(1):17-21. [Medline].
Wall DB, Klein SR, Black S, de Virgilio C. A simple model to help distinguish necrotizing fasciitis from nonnecrotizing soft tissue infection. J Am Coll Surg. Sep 2000;191(3):227-31. [Medline].
Further Reading
Keywords
necrotizing fasciitis, hospital gangrene, acute infective gangrene, necrotizing erysipelas, hemolytic streptococcus gangrene, suppurative fasciitis, flesh-eating bacterial infection, killer bug disease, Fournier's gangrene, Fournier gangrene, polymicrobial necrotizing fasciitis, group A streptococcal necrotizing fasciitis, gas gangrene, clostridial myonecrosis, fascial necrosis, group A beta-hemolytic streptococci, septicemia
streptococcal pyrogenic exotoxins, streptococcal superantigen, frostbite, chronic venous leg ulcers, open bone fractures, insect bites, surgical wounds, skin abscesses, diabetes mellitus, violaceous discoloration, black necrotic eschar, metastatic cutaneous plaques, nonclostridial anaerobic infections, blistering necrosis, cyanosis, Haemophilus aphrophilus, Staphylococcus, phycomycetesVibrio species, varicella infection, Clostridium perfringens, Clostridium septicum, colon cancer, leukemia
Follow-up: Necrotizing Fasciitis