Eruptive Vellus Hair Cysts Medication
- Author: Cory A Dunnick, MD; Chief Editor: William D James, MD more...
The goals of pharmacotherapy for eruptive vellus hair cysts (EVHCs) are to reduce morbidity and to prevent complications.
Topical Skin Products
Modulate keratinocyte differentiation and decrease oil production.
Contains lactic acid, an alpha-hydroxy acid that has keratolytic action, thus facilitating release of comedones. Alpha-hydroxy acids cause disadhesion of corneocytes and thin the stratum corneum. Use 12% cream or lotion.
Topical humectant. Promotes hydration and removal of excess keratin. Urea is a small molecule that osmotically binds water. Use 10% or 20% cream.
These agents stimulate cellular retinoid receptors and help normalize keratinocyte differentiation and are comedolytic. In addition, they have anti-inflammatory properties.
Retinoid prodrug whose active metabolite modulates differentiation and proliferation of epithelial tissue; may also have anti-inflammatory and immunomodulatory properties. Available as 0.05% and 0.1% cream and gel.
Topical retinoid that significantly alters the differentiation of keratinocytes. Inhibits microcomedo formation and eliminates lesions. Makes keratinocytes in sebaceous follicles less adherent and easier to remove. Available as 0.025%, 0.05%, and 0.1% creams. Available also as 0.01% and 0.025% gels.
Esterly NB, Fretzin DF, Pinkus H. Eruptive vellus hair cysts. Arch Dermatol. 1977 Apr. 113(4):500-3. [Medline].
Binhlam JQ, Gross AS, Onadeko OO, Dutt PL, King LE Jr. Acneiform eruption due to eruptive vellus hair cysts. South Med J. 1992 Mar. 85(3):322-5. [Medline].
Reep MD, Robson KJ. Eruptive vellus hair cysts presenting as multiple periorbital papules in a 13-year-old boy. Pediatr Dermatol. 2002 Jan-Feb. 19(1):26-7. [Medline].
Park JH, Her Y, Chun BM, Kim CW, Kim SS. A case of eruptive vellus hair cysts that developed on the labium major. Ann Dermatol. 2009 Aug. 21(3):294-6.
Benoldi D, Allegra F. Congenital eruptive vellus hair cysts. Int J Dermatol. 1989 Jun. 28(5):340-1. [Medline].
Mayron R, Grimwood RE. Familial occurrence of eruptive vellus hair cysts. Pediatr Dermatol. 1988 May. 5(2):94-6. [Medline].
Rodgers SA, Kitagawa K, Selim MA, Bellet JS. Familial eruptive vellus hair cysts. Pediatr Dermatol. 2012 May. 29(3):367-9. [Medline].
Yanik ME, Aliagaoglu C, Güvenç SC, Yildirim U, Albayrak H. Eruptive vellus hair cysts occurring on the ears. J Dermatol. 2009 Jun. 36(6):360-1. [Medline].
Lew BL, Lee MH, Haw CR. Unilateral eruptive vellus hair cysts occurring on the face. J Eur Acad Dermatol Venereol. 2006 Nov. 20(10):1314-6. [Medline].
Chan KH, Tang WY, Lam WY, Lo KK. Eruptive vellus hair cysts presenting as bluish-grey facial discoloration masquering as naevus of Ota. Br J Dermatol. 2007 Jul. 157(1):188-9. [Medline].
Li Y, Shan SJ, Luo S, Zhang S, Liu Q. Eruptive vellus hair cysts in association with syringomas. Eur J Dermatol. 2012 May-Jun. 22(3):394-5. [Medline].
Lee HT, Chang SH, Yoon TY. Eruptive vellus hair cyst in a patient with pachyonychia congenita. J Dermatol. 1999 Jun. 26(6):402-4. [Medline].
Takeshita T, Takeshita H, Irie K. Eruptive vellus hair cyst and epidermoid cyst in a patient with pachyonychia congenita. J Dermatol. 2000 Oct. 27(10):655-7. [Medline].
Romiti R, Festa Neto C. Eruptive vellus hair cysts in a patient with ectodermal dysplasia. J Am Acad Dermatol. 1997 Feb. 36(2 Pt 1):261-2. [Medline].
Köse O, Tastan HB, Deveci S, Gür AR. Anhidrotic ectodermal dysplasia with eruptive vellus hair cysts. Int J Dermatol. 2001 Jun. 40(6):401-2. [Medline].
Mieno H, Fujimoto N, Tajima S. Eruptive vellus hair cyst in patients with chronic renal failure. Dermatology. 2004. 208(1):67-9. [Medline].
Morgan MB, Kouseff BG, Silver A, et al. Eruptive vellus hair cysts and neurologic abnormalities: two related conditions?. Cutis. 1991 Jun. 47(6):413-5. [Medline].
Nandedkar MA, Minus H, Nandedkar MA. Eruptive vellus hair cysts in a patient with Lowe syndrome. Pediatr Dermatol. 2004 Jan-Feb. 21(1):54-7. [Medline].
Kaya TI, Tataroglu C, Tursen U, Ikizoglu G. Eruptive vellus hair cysts: an effective extraction technique for treatment and diagnosis. J Eur Acad Dermatol Venereol. 2006 Mar. 20(3):264-8. [Medline].
Alfaro-Castellon P, Mejia-Rodriguez SA, Valencia-Herrera A, Ramírez S, Mena-Cedillos C. Dermoscopy Distinction of Eruptive Vellus Hair Cysts with Molluscum Contagiosum and Acne Lesions. Pediatr Dermatol. 2012 May 29. [Medline].
Kiene P, Hauschild A, Christophers E. Eruptive vellus hair cysts and steatocystoma multiplex. variants of one entity?. Br J Dermatol. 1996 Feb. 134(2):365-7. [Medline].
Zaharia D, Kanitakis J. Eruptive vellus hair cysts: report of a new case with immunohistochemical study and literature review. Dermatology. 2012. 224(1):15-9. [Medline].
Tomková H, Fujimoto W, Arata J. Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Am J Dermatopathol. 1997 Jun. 19(3):250-3. [Medline].
Ahn SK, Chung J, Lee WS, Lee SH, Choi EH. Hybrid cysts showing alternate combination of eruptive vellus hair cyst, steatocystoma multiplex, and epidermoid cyst, and an association among the three conditions. Am J Dermatopathol. 1996 Dec. 18(6):645-9. [Medline].
Jerasutus S, Suvanprakorn P, Sombatworapat W. Eruptive vellus hair cyst and steatocystoma multiplex. J Am Acad Dermatol. 1989 Feb. 20(2 Pt 1):292-3. [Medline].
Ohtake N, Kubota Y, Takayama O, Shimada S, Tamaki K. Relationship between steatocystoma multiplex and eruptive vellus hair cysts. J Am Acad Dermatol. 1992 May. 26(5 Pt 2):876-8. [Medline].
Saks K, Levitt JO. Tazarotene 0.1 percent cream fares better than erbium:YAG laser or incision and drainage in a patient with eruptive vellus hair cysts. Dermatol Online J. 2006. 12(6):7. [Medline].
Urbina-González F, Aguilar-Martínez A, Cristóbal-Gil MC, Sánchez de Paz F. The treatment of eruptive vellus hair cysts with isotretinoin. Br J Dermatol. 1987 Mar. 116(3):465-6. [Medline].
Erkek E, Kurtipek GS, Duman D, Sanli C, Erdogan S. Eruptive vellus hair cysts: report of a pediatric case with partial response to calcipotriene therapy. Cutis. 2009 Dec. 84(6):295-8. [Medline].
Sárdy M, Kárpáti S. Needle evacuation of eruptive vellus hair cysts. Br J Dermatol. 1999 Sep. 141(3):594-5. [Medline].
Huerter CJ, Wheeland RG. Multiple eruptive vellus hair cysts treated with carbon dioxide laser vaporization. J Dermatol Surg Oncol. 1987 Mar. 13(3):260-3. [Medline].
Kageyama N, Tope WD. Treatment of multiple eruptive hair cysts with erbium:YAG laser. Dermatol Surg. 1999 Oct. 25(10):819-22. [Medline].
Coras B, Hohenleutner U, Landthaler M, Hohenleutner S. Early recurrence of eruptive vellus hair cysts after Er:YAG laser therapy: case report and review of the literature. Dermatol Surg. 2005 Dec. 31(12):1741-4. [Medline].
Helbig D, Bodendorf MO, Grunewald S, et al. Comparative treatment of multiple vellus hair cysts with the 2940 nm Er:YAG and 1540 nm Er:Glass laser. J Cosmet Laser Ther. 2011 Oct. 13(5):223-6. [Medline].