Fibrous Papule of the Face

Updated: Mar 10, 2017
  • Author: Simone Laube, MD, MRCP; Chief Editor: Dirk M Elston, MD  more...
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Overview

Background

Fibrous papule of the face is a benign, clinically indistinct papule, also known as sporadic angiofibroma. 

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Pathophysiology

In the past, fibrous papule has been suggested to have been derived from preexisting or involuting melanocytic nevi; however, subsequent investigations appear to have refuted this and have confirmed a relationship to factor XIIIa – positive dermal dendrocytes. Fibrous papule is best considered a variant of angiofibroma. [1]

A study from 2014 showed expression of antibodies against p-mTOR in dermal stromal cells and epidermal keratinocytes in fibrous papules, similar to tuberous-sclerosis complex–associated facial angiofibromas, suggesting topical rapamycin may be a treatment option. [2]  

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Epidemiology

Frequency

The condition is relatively common.

Race

No racial predilection is known.

Sex

Both sexes are equally affected.

Age

Most of the patients are in their third to fifth decade of life.

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Prognosis

Fibrous papule of the face is a benign lesion. Most of the lesions are asymptomatic, although one third of patients have reported bleeding following minor trauma.

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Patient Education

The patient should be reassured that the lesion is harmless. Patients should also be made aware that a surgical procedure results in a scar.

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