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Follicular Infundibulum Tumor Clinical Presentation

  • Author: Brad S Graham, MD; Chief Editor: William D James, MD  more...
 
Updated: Aug 18, 2015
 

History

The clinical features of follicular infundibulum tumor depend on the subtype, which may be either solitary or eruptive. In the eruptive form, multiple lesions develop over time. Neither subtype usually causes symptoms.

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Physical

Solitary follicular infundibulum tumors have no distinctive clinical features. Usually, a solitary tumor presents as a scaly nodule up to 1.5 cm in diameter and located on the head or neck. A solitary tumor frequently is misdiagnosed as basal cell carcinoma or seborrheic keratosis.

Eruptive follicular infundibulum tumor lesions have been described in most reports as a sudden onset of multiple (up to 200), variably scaling, hypopigmented macules and papules confined to the head, neck, and upper trunk.[3] They resemble tinea versicolor, pityriasis alba, or disseminated superficial actinic porokeratosis. Vitiligolike hypopigmented facial macules have also been reported.[4] The terms infundibulomas and infundibulomatosis apply to the eruptive form.

An article from 2004 described a case of multiple infundibulomas manifesting as hundreds of 4- to 10-mm red-brown papules in the intertriginous areas, resembling Darier disease.[5] A 2009 article described ill-defined, scaly, reticulated plaques on photodamaged skin resembling eczema craquel é, located on the bilateral sides of the face and neck. These plaques were of 5 years' duration and were accentuated with sun exposure. Biopsy showed multiple infundibulomas.[6]

Rare cases have been associated with nevus sebaceous and Cowden syndrome.[7]

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Causes

The cause of follicular infundibulum tumor is unknown.

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Contributor Information and Disclosures
Author

Brad S Graham, MD Consulting Staff, Dermatology Associates of Tyler

Brad S Graham, MD is a member of the following medical societies: Alpha Omega Alpha, Texas Dermatological Society, American Academy of Dermatology, American Society of Dermatopathology

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Edward F Chan, MD Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania School of Medicine

Edward F Chan, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

References
  1. Mehregan AH, Butler JD. A tumor of follicular infundibulum. Report of a case. Arch Dermatol. 1961 Jun. 83:924-7. [Medline].

  2. Koch B, Rufli T. Tumor of follicular infundibulum. Dermatologica. 1991. 183(1):68-9. [Medline].

  3. Kossard S, Finley AG, Poyzer K, Kocsard E. Eruptive infundibulomas. A distinctive presentation of the tumor of follicular infundibulum. J Am Acad Dermatol. 1989 Aug. 21(2 Pt 2):361-6. [Medline].

  4. Sartorelli AC, Leite FE, Friedman IV, Friedman H. Vitiligoid hypopigmented macules and tumor of the follicular infundibulum. An Bras Dermatol. 2009 Jan-Feb. 84(1):68-70. [Medline]. [Full Text].

  5. Cheng AC, Chang YL, Wu YY, Hu SL, Chuan MT. Multiple tumors of the follicular infundibulum. Dermatol Surg. 2004 Sep. 30(9):1246-8. [Medline].

  6. Martin JE, Hsu MY, Wang LC. An unusual clinical presentation of multiple tumors of the follicular infundibulum. J Am Acad Dermatol. 2009 May. 60(5):885-6. [Medline].

  7. Cribier B, Grosshans E. Tumor of the follicular infundibulum: a clinicopathologic study. J Am Acad Dermatol. 1995 Dec. 33(6):979-84. [Medline].

  8. Mahalingam M, Bhawan J, Finn R, Stefanato CM. Tumor of the follicular infundibulum with sebaceous differentiation. J Cutan Pathol. 2001 Jul. 28(6):314-7. [Medline].

  9. Kolenik SA 3rd, Bolognia JL, Castiglione FM Jr, Longley BJ. Multiple tumors of the follicular infundibulum. Int J Dermatol. 1996 Apr. 35(4):282-4. [Medline].

  10. MacGregor JL, Campanelli C, Friedman PC, Desciak E. Basal cell and squamous cell carcinoma occurring within a field of multiple tumors of the follicular infundibulum. Dermatol Surg. 2008 Nov. 34(11):1567-70. [Medline].

  11. Abbas O, Mahalingam M. Tumor of the follicular infundibulum: an epidermal reaction pattern?. Am J Dermatopathol. 2009 Oct. 31(7):626-33. [Medline].

  12. Weyers W, Hörster S, Diaz-Cascajo C. Tumor of follicular infundibulum is Basal cell carcinoma. Am J Dermatopathol. 2009 Oct. 31(7):634-41. [Medline].

 
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Tumor of the follicular infundibulum shows a platelike dermal tumor with anastomosing islands and cords with connections to the overlying epidermis and horn cysts (hematoxylin and eosin stain, 40X magnification).
Tumor of the follicular infundibulum shows epidermal connections, horn cysts, and anastomosing islands (hematoxylin and eosin stain, 100X magnification).
Tumor of the follicular infundibulum shows epidermal connections, peripheral palisading, and horn cyst (hematoxylin and eosin stain, 400X magnification).
 
 
 
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