Infantile Digital Fibromatosis Medication

  • Author: Theresa Schroeder Devere, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jan 12, 2012
 

Medication Summary

Topical corticosteroids with or without occlusion have not shown any benefit in infantile digital fibromatosis; however, intralesional corticosteroids or fluorouracil may prove beneficial.[10, 11]

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Corticosteroids

Class Summary

Anti-inflammatory agents may induce regression of dermal infiltrative lesions.

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Triamcinolone (Aristocort)

 

For inflammatory dermatosis responsive to steroids. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. Can be injected intralesionally.

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Antimetabolites

Class Summary

These agents inhibit cell growth and proliferation.

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Fluorouracil (Efudex, Adrucil, Fluoroplex)

 

Pyrimidine analogue shown to inhibit dermal fibroblast proliferation and collagen synthesis in cell culture.

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Contributor Information and Disclosures
Author

Theresa Schroeder Devere, MD  Assistant Professor of Dermatology, Residency Director, Oregon Health Sciences University

Theresa Schroeder Devere, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Coauthor(s)

Susan Bayliss Mallory, MD  Director of Pediatric Dermatology, Departments of Internal Medicine and Pediatrics, Professor, Saint Louis Children's Hospital, Washington University

Susan Bayliss Mallory, MD is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Jean Paul Ortonne, MD  Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France

Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology and American Dermatological Association

Disclosure: Nothing to disclose.

Michael J Wells, MD  Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

Van Perry, MD  Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas School of Medicine at San Antonio

Van Perry, MD is a member of the following medical societies: American Academy of Dermatology and American Society for Laser Medicine and Surgery

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Ackerman Academy of Dermatopathology, New York

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References

  1. Reye RD. Recrring Digital Fibrous tumors of childhood. Arch Pathol. Sep 1965;80:228-31. [Medline].

  2. Laskin WB, Miettinen M, Fetsch JF. Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up. Am J Surg Pathol. Jan 2009;33(1):1-13. [Medline].

  3. Taylor HO, Gellis SE, Schmidt BA, Upton J, Rogers GF. Infantile digital fibromatosis. Ann Plast Surg. Oct 2008;61(4):472-6. [Medline].

  4. Choi KC, Hashimoto K, Setoyama M, Kagetsu N, Tronnier M, Sturman S. Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. J Cutan Pathol. Aug 1990;17(4):225-32. [Medline].

  5. Ishii N, Matsui K, Ichiyama S, et al. A case of infantile digital fibromatosis showing spontaneous regression.. Br J Dermatol. Jul 1989;121(1):129-33. [Medline].

  6. Kawaguchi M, Mitsuhashi Y, Hozumi Y, Kondo S. A case of infantile digital fibromatosis with spontaneous regression. J Dermatol. Aug 1998;25(8):523-6. [Medline].

  7. Niamba P, Leaute-Labreze C, Boralevi F, et al. Further documentation of spontaneous regression of infantile digital fibromatosis. Pediatr Dermatol. May-Jun 2007;24(3):280-4. [Medline].

  8. Spingardi O, Zoccolan A, Venturino E. Infantile digital fibromatosis: our experience and long-term results. Chir Main. Feb 2011;30(1):62-5. [Medline].

  9. Albertini JG, Welsch MJ, Conger LA, Libow LF, Elston DM. Infantile digital fibroma treated with mohs micrographic surgery. Dermatol Surg. Oct 2002;28(10):959-61. [Medline].

  10. Oh CK, Son HS, Kwon YW, Jang HS, Kwon KS. Intralesional fluorouracil injection in infantile digital fibromatosis. Arch Dermatol. May 2005;141(5):549-50. [Medline].

  11. Holmes WJ, Mishra A, McArthur P. Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. J Plast Reconstr Aesthet Surg. May 2011;64(5):632-7. [Medline].

  12. Azam SH, Nicholas JL. Recurring infantile digital fibromatosis: report of two cases. J Pediatr Surg. Jan 1995;30(1):89-90. [Medline].

  13. Dabney KW, MacEwen GD, Davis NE. Recurring digital fibrous tumor of childhood: case report with long-term follow-up and review of the literature. J Pediatr Orthop. Sep-Oct 1986;6(5):612-7. [Medline].

  14. O'Gorman DJ. Infantile digital fibromatosis. Proc R Soc Med. Sep 1974;67(9):880. [Medline].

 
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Dermal tumor with interlacing spindle-shaped cells and collagen bundles. Perinuclear eosinophilic inclusion bodies are not visible at this magnification.
Firm, nontender, erythematous nodule on the fifth finger of a 17-month-old boy.
A dermal nodule extending into the subcutaneous fat.
 
 
 
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