Infantile Digital Fibromatosis Workup

  • Author: Theresa Schroeder Devere, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jan 12, 2012
 

Procedures

A skin biopsy is recommended to confirm the diagnosis of infantile digital fibromatosis.

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Histologic Findings

Unique histologic features are diagnostic of infantile digital fibromatosis. Interlacing fascicles of spindle-shaped myofibroblast cells and collagen bundles form a dermal nodule. The nodule may extend into the subcutaneous tissue. The ovoid nuclei of the cells are accompanied by characteristic perinuclear eosinophilic cytoplasmic inclusion bodies. Immunohistochemical stains positive for vimentin, cytokeratin, desmin, calponin, and alpha-smooth muscle actin.[4]

Dermal tumor with interlacing spindle-shaped cellsDermal tumor with interlacing spindle-shaped cells and collagen bundles. Perinuclear eosinophilic inclusion bodies are not visible at this magnification. A dermal nodule extending into the subcutaneous faA dermal nodule extending into the subcutaneous fat.
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Contributor Information and Disclosures
Author

Theresa Schroeder Devere, MD  Assistant Professor of Dermatology, Residency Director, Oregon Health Sciences University

Theresa Schroeder Devere, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Coauthor(s)

Susan Bayliss Mallory, MD  Director of Pediatric Dermatology, Departments of Internal Medicine and Pediatrics, Professor, Saint Louis Children's Hospital, Washington University

Susan Bayliss Mallory, MD is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Jean Paul Ortonne, MD  Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France

Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology and American Dermatological Association

Disclosure: Nothing to disclose.

Michael J Wells, MD  Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

Van Perry, MD  Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas School of Medicine at San Antonio

Van Perry, MD is a member of the following medical societies: American Academy of Dermatology and American Society for Laser Medicine and Surgery

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Ackerman Academy of Dermatopathology, New York

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References

  1. Reye RD. Recrring Digital Fibrous tumors of childhood. Arch Pathol. Sep 1965;80:228-31. [Medline].

  2. Laskin WB, Miettinen M, Fetsch JF. Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up. Am J Surg Pathol. Jan 2009;33(1):1-13. [Medline].

  3. Taylor HO, Gellis SE, Schmidt BA, Upton J, Rogers GF. Infantile digital fibromatosis. Ann Plast Surg. Oct 2008;61(4):472-6. [Medline].

  4. Choi KC, Hashimoto K, Setoyama M, Kagetsu N, Tronnier M, Sturman S. Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. J Cutan Pathol. Aug 1990;17(4):225-32. [Medline].

  5. Ishii N, Matsui K, Ichiyama S, et al. A case of infantile digital fibromatosis showing spontaneous regression.. Br J Dermatol. Jul 1989;121(1):129-33. [Medline].

  6. Kawaguchi M, Mitsuhashi Y, Hozumi Y, Kondo S. A case of infantile digital fibromatosis with spontaneous regression. J Dermatol. Aug 1998;25(8):523-6. [Medline].

  7. Niamba P, Leaute-Labreze C, Boralevi F, et al. Further documentation of spontaneous regression of infantile digital fibromatosis. Pediatr Dermatol. May-Jun 2007;24(3):280-4. [Medline].

  8. Spingardi O, Zoccolan A, Venturino E. Infantile digital fibromatosis: our experience and long-term results. Chir Main. Feb 2011;30(1):62-5. [Medline].

  9. Albertini JG, Welsch MJ, Conger LA, Libow LF, Elston DM. Infantile digital fibroma treated with mohs micrographic surgery. Dermatol Surg. Oct 2002;28(10):959-61. [Medline].

  10. Oh CK, Son HS, Kwon YW, Jang HS, Kwon KS. Intralesional fluorouracil injection in infantile digital fibromatosis. Arch Dermatol. May 2005;141(5):549-50. [Medline].

  11. Holmes WJ, Mishra A, McArthur P. Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. J Plast Reconstr Aesthet Surg. May 2011;64(5):632-7. [Medline].

  12. Azam SH, Nicholas JL. Recurring infantile digital fibromatosis: report of two cases. J Pediatr Surg. Jan 1995;30(1):89-90. [Medline].

  13. Dabney KW, MacEwen GD, Davis NE. Recurring digital fibrous tumor of childhood: case report with long-term follow-up and review of the literature. J Pediatr Orthop. Sep-Oct 1986;6(5):612-7. [Medline].

  14. O'Gorman DJ. Infantile digital fibromatosis. Proc R Soc Med. Sep 1974;67(9):880. [Medline].

 
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Dermal tumor with interlacing spindle-shaped cells and collagen bundles. Perinuclear eosinophilic inclusion bodies are not visible at this magnification.
Firm, nontender, erythematous nodule on the fifth finger of a 17-month-old boy.
A dermal nodule extending into the subcutaneous fat.
 
 
 
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