Close
New

Medscape is available in 5 Language Editions – Choose your Edition here.

 

Infantile Digital Fibromatosis Workup

  • Author: Monique Gupta Kumar, MD; Chief Editor: Dirk M Elston, MD  more...
 
Updated: Jul 18, 2016
 

Procedures

A skin biopsy can confirm the diagnosis of infantile digital fibromatosis.

Next

Histologic Findings

Unique histologic features are diagnostic of infantile digital fibromatosis. Interlacing fascicles of uniform spindle-shaped myofibroblast cells and collagen bundles are seen in the dermis or subcutis. A characteristic feature is the presence of distinctive, perinuclear, eosinophilic cytoplasmic inclusion bodies. Masson trichrome stains these characteristic perinuclear inclusion bodies red. Immunohistochemical stains are positive for vimentin, cytokeratin, desmin, calponin, and alpha-smooth muscle actin.[5]

See the images below.

Dermal tumor with interlacing spindle-shaped cellsDermal tumor with interlacing spindle-shaped cells and collagen bundles. Perinuclear eosinophilic inclusion bodies are not visible at this magnification.
A dermal nodule extending into the subcutaneous faA dermal nodule extending into the subcutaneous fat.
Previous
 
 
Contributor Information and Disclosures
Author

Monique Gupta Kumar, MD MPhil, Assistant Professor of Dermatology, Emory University School of Medicine

Monique Gupta Kumar, MD is a member of the following medical societies: American Academy of Dermatology, International Society of Dermatology, Society for Pediatric Dermatology, Pediatric Dermatology Research Alliance

Disclosure: Nothing to disclose.

Coauthor(s)

Susan Joy Bayliss, MD Director of Pediatric Dermatology, Departments of Internal Medicine and Pediatrics, St Louis Children's Hospital; Professor, Washington University in St Louis School of Medicine

Susan Joy Bayliss, MD is a member of the following medical societies: American Academy of Dermatology, American Academy of Pediatrics, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Michael J Wells, MD, FAAD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Van Perry, MD Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas School of Medicine at San Antonio

Van Perry, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Jean Paul Ortonne, MD Chair, Department of Dermatology, Professor, Hospital L'Archet, Nice University, France

Jean Paul Ortonne, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Acknowledgements

Theresa Schroeder Devere, MD Assistant Professor of Dermatology, Residency Director, Oregon Health Sciences University

Theresa Schroeder Devere, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

References
  1. Reye RD. Recrring Digital Fibrous tumors of childhood. Arch Pathol. 1965 Sep. 80:228-31. [Medline].

  2. Laskin WB, Miettinen M, Fetsch JF. Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up. Am J Surg Pathol. 2009 Jan. 33(1):1-13. [Medline].

  3. Taylor HO, Gellis SE, Schmidt BA, Upton J, Rogers GF. Infantile digital fibromatosis. Ann Plast Surg. 2008 Oct. 61(4):472-6. [Medline].

  4. Kaya A, Yuca SA, Karaman K, Erten R, Dogan M, Bektas MS, et al. Infantile digital fibromatosis (inclusion body fibromatosis) observed in a baby without finger involvement. Indian J Dermatol. 2013 Mar. 58(2):160. [Medline]. [Full Text].

  5. Choi KC, Hashimoto K, Setoyama M, Kagetsu N, Tronnier M, Sturman S. Infantile digital fibromatosis. Immunohistochemical and immunoelectron microscopic studies. J Cutan Pathol. 1990 Aug. 17(4):225-32. [Medline].

  6. Ishii N, Matsui K, Ichiyama S, et al. A case of infantile digital fibromatosis showing spontaneous regression. Br J Dermatol. 1989 Jul. 121(1):129-33. [Medline].

  7. Kawaguchi M, Mitsuhashi Y, Hozumi Y, Kondo S. A case of infantile digital fibromatosis with spontaneous regression. J Dermatol. 1998 Aug. 25(8):523-6. [Medline].

  8. Niamba P, Leaute-Labreze C, Boralevi F, et al. Further documentation of spontaneous regression of infantile digital fibromatosis. Pediatr Dermatol. 2007 May-Jun. 24(3):280-4. [Medline].

  9. Azam SH, Nicholas JL. Recurring infantile digital fibromatosis: report of two cases. J Pediatr Surg. 1995 Jan. 30(1):89-90. [Medline].

  10. Spingardi O, Zoccolan A, Venturino E. Infantile digital fibromatosis: our experience and long-term results. Chir Main. 2011 Feb. 30(1):62-5. [Medline].

  11. Albertini JG, Welsch MJ, Conger LA, Libow LF, Elston DM. Infantile digital fibroma treated with mohs micrographic surgery. Dermatol Surg. 2002 Oct. 28(10):959-61. [Medline].

  12. Oh CK, Son HS, Kwon YW, Jang HS, Kwon KS. Intralesional fluorouracil injection in infantile digital fibromatosis. Arch Dermatol. 2005 May. 141(5):549-50. [Medline].

  13. Holmes WJ, Mishra A, McArthur P. Intra-lesional steroid for the management of symptomatic Infantile Digital Fibromatosis. J Plast Reconstr Aesthet Surg. 2011 May. 64(5):632-7. [Medline].

Previous
Next
 
Dermal tumor with interlacing spindle-shaped cells and collagen bundles. Perinuclear eosinophilic inclusion bodies are not visible at this magnification.
Firm, nontender, erythematous nodule on the fifth finger of a 17-month-old boy.
A dermal nodule extending into the subcutaneous fat.
 
 
 
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.