eMedicine Specialties > Dermatology > Benign Neoplasms
Nevi of Ota and Ito: Treatment & Medication
Updated: Jul 14, 2008
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Treatment
Medical Care
Cosmetic camouflage makeup can minimize the disfiguring facial pigmentation resulting from nevus of Ota. Otherwise, topical therapy is of no value in the medical treatment of nevi of Ota and Ito.
Surgical Care
- Laser surgery6
- Pulsed Q-switched laser surgery is unquestionably the current treatment of choice for nevi of Ota and Ito, and it works via selective photothermal and photomechanical destruction of dermal melanocytes and melanophages.
- High success rates and minimal adverse effects have been reported with the Q-switched ruby,7 Q-switched alexandrite,8,9 and Q-switched Nd:YAG lasers.8
- After 4-8 treatments, skin pigmentation is reduced dramatically or removed in 90-100% of cases, with a less than 1% risk of scarring.
- Other surgical methods (currently have been superseded by laser surgery)
- Cryotherapy10
- Microsurgery
- Dermabrasion (alone or combined with other modalities, such as carbon dioxide snow, autologous epithelial grafting)
- Sequential dry ice epidermal peeling
- The Medscape Dermatologic Surgery Resource Center may be helpful.
Consultations
Ophthalmologist - For nevus of Ota, which may be associated with a higher incidence of ocular disease
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| Overview: Nevi of Ota and Ito |
| Differential Diagnoses & Workup: Nevi of Ota and Ito |
Treatment & Medication: Nevi of Ota and Ito |
| Follow-up: Nevi of Ota and Ito |
| References |
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References
Ito M. Studies on melanin XXII. Nevus fuscocaeruleus acromio-deltoideus. Tohoko J Exper Med. 1954;60:10.
Patel BC, Egan CA, Lucius RW, Gerwels JW, Mamalis N, Anderson RL. Cutaneous malignant melanoma and oculodermal melanocytosis (nevus of Ota): report of a case and review of the literature. J Am Acad Dermatol. May 1998;38(5 Pt 2):862-5. [Medline].
van Krieken JH, Boom BW, Scheffer E. Malignant transformation in a naevus of Ito. A case report. Histopathology. Jan 1988;12(1):100-2. [Medline].
Teekhasaenee C, Ritch R, Rutnin U, Leelawongs N. Glaucoma in oculodermal melanocytosis. Ophthalmology. May 1990;97(5):562-70. [Medline].
Hirayama T, Suzuki T. A new classification of Ota's nevus based on histopathological features. Dermatologica. 1991;183(3):169-72. [Medline].
Anderson RR. Lasers in dermatology--a critical update. J Dermatol. Nov 2000;27(11):700-5. [Medline].
Watanabe S, Takahashi H. Treatment of nevus of Ota with the Q-switched ruby laser. N Engl J Med. Dec 29 1994;331(26):1745-50. [Medline].
Chan HH, Leung RS, Ying SY, Lai CF, Kono T, Chua JK, et al. A retrospective analysis of complications in the treatment of nevus of Ota with the Q-switched alexandrite and Q-switched Nd:YAG lasers. Dermatol Surg. Nov 2000;26(11):1000-6. [Medline].
Wang HW, Liu YH, Zhang GK, Jin HZ, Zuo YG, Jiang GT, et al. Analysis of 602 Chinese cases of nevus of Ota and the treatment results treated by Q-switched alexandrite laser. Dermatol Surg. Apr 2007;33(4):455-60. [Medline].
Hosaka Y, Onizuka T, Ichinose M, Yoshimoto S, Okubo F, Hori S, et al. Treatment of nevus Ota by liquid nitrogen cryotherapy. Plast Reconstr Surg. Apr 1995;95(4):703-11. [Medline].
Hidano A, Kajima H, Ikeda S, Mizutani H, Miyasato H, Niimura M. Natural history of nevus of Ota. Arch Dermatol. Feb 1967;95(2):187-95. [Medline].
Further Reading
Keywords
hamartoma, nevus of Ota, nevus of Ito, Hori nevus, Hori's nevus, nevus fuscoceruleus zygomaticus, plaque-type variant of blue nevus, nevus fuscoceruleus acromiodeltoideus
Treatment & Medication: Nevi of Ota and Ito