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Nevus Comedonicus Treatment & Management

  • Author: Rossitza Lazova, MD; Chief Editor: William D James, MD  more...
 
Updated: Jun 27, 2016
 

Medical Care

Asymptomatic lesions may be left untreated or therapy may be implemented for cosmetic concerns. Some lesions improve with topical retinoic acid,[31] salicylic acid, or ammonium lactate lotion.[32]

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Surgical Care

Disfiguring lesions may require surgical interventions. Laser treatment may be used.[33, 34]

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Consultations

If defects associated with a nevus comedonicus syndrome are found, consult the appropriate specialist, as follows:

  • Neurologist for seizure disorders
  • Ophthalmologist for cataracts
  • Orthopedist for skeletal deformities
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Contributor Information and Disclosures
Author

Rossitza Lazova, MD Associate Professor of Dermatology and Pathology, Director of Dermatopathology Residency and Fellowship Program, Yale University School of Medicine; Consulting Pathologist/Dermatopathologist, Veterans Affairs Medical Center, West Haven, Connecticut

Rossitza Lazova, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, International Society of Dermatopathology

Disclosure: Nothing to disclose.

Specialty Editor Board

Michael J Wells, MD, FAAD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Lester F Libow, MD Dermatopathologist, South Texas Dermatopathology Laboratory

Lester F Libow, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Texas Medical Association

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Barbara R Reed, MD Clinical Professor, Department of Dermatology, Dermatology Service, Denver Veterans Affairs Medical Center, University of Colorado Health Sciences Center; Consulting Staff, Denver Skin Clinic

Disclosure: Nothing to disclose.

Acknowledgements

The authors and editors of Medscape Reference gratefully acknowledge the contributions of previous authors Joseph J. Shaffer, MBBS, Vincent A. de Leo, MD, to the development and writing of this article.

References
  1. Kofmann S. A case of rare localization and spreading of comedones. Arch Dermatol Syphilol. 1895. 32:177-8.

  2. Patrizi A, Neri I, Fiorentini C, Marzaduri S. Nevus comedonicus syndrome: a new pediatric case. Pediatr Dermatol. 1998 Jul-Aug. 15(4):304-6. [Medline].

  3. Engber PB. The nevus comedonicus syndrome: a case report with emphasis on associated internal manifestations. Int J Dermatol. 1978 Nov. 17(9):745-9. [Medline].

  4. Martinez M, Levrero P, Bazzano C, Larre Borges A, De Anda G. Nevus comedonicus syndrome in a woman with Paget bone disease and breast cancer: a mere coincidence?. Eur J Dermatol. 2006 Nov-Dec. 16(6):697-8. [Medline].

  5. Giam YC, Ong BH, Rajan VS. Naevus comedonicus in homozygous twins. Dermatologica. 1981. 162(4):249-53. [Medline].

  6. Grimalt R, Caputo R. Posttraumatic nevus comedonicus. J Am Acad Dermatol. 1993 Feb. 28(2 Pt 1):273-4. [Medline].

  7. Vasiloudes PE, Morelli JG, Weston WL. Inflammatory nevus comedonicus in children. J Am Acad Dermatol. 1998 May. 38(5 Pt 2):834-6. [Medline].

  8. Kirtak N, Inaloz HS, Karakok M, Erguven HG, Ozgoztasi O. Extensive inflammatory nevus comedonicus involving half of the body. Int J Dermatol. 2004 Jun. 43(6):434-6. [Medline].

  9. Asokan N, Sridevi PK. Inflammatory nevus comedonicus in an infant. Nov-Dec/2008.

  10. Bettoli V, Toni G, Ricci M, Zauli S, Virgili A. Hidradenitis suppurativa-acne inversa-like lesions complicating naevus comedonicus: second case supporting the mechanical stress as a triggering factor. G Ital Dermatol Venereol. 2016 Jun. 151 (3):306-7. [Medline].

  11. Qian G, Liu T, Zhou C, Zhang Y. Naevus comedonicus syndrome complicated by hidradenitis suppurativa-like lesions responding to acitretin treatment. Acta Derm Venereol. 2015 Nov. 95 (8):992-3. [Medline].

  12. Sikorski D, Parker J, Shwayder T. A boy with an unusual scalp birthmark. Nevus Comedonicus. Int J Dermatol. 2011 Jun. 50(6):670-2. [Medline].

  13. Arias-Santiago S, Aneiros-Fernandez J, Buendia-Eisman A, Giron-Prieto MS, Aneiros-Cachaza J. Unknown: A 5-year-old boy with comedo-like lesions on the right buttock. Dermatology Online Journal. 16:11. [Medline]. [Full Text].

  14. Ghaninezhad H, Ehsani AH, Mansoori P, Taheri A. Naevus comedonicus of the scalp. J Eur Acad Dermatol Venereol. 2006 Feb. 20(2):184-5. [Medline].

  15. Guldbakke KK, Khachemoune A, Deng A, Sina B. Naevus comedonicus: a spectrum of body involvement. Clin Exp Dermatol. 2007 Sep. 32(5):488-92. [Medline].

  16. Lefkowitz A, Schwartz RA, Lambert WC. Nevus comedonicus. Dermatology. 1999. 199(3):204-7. [Medline].

  17. Nabai H, Mehregan AH. Nevus comedonicus. A review of the literature and report of twelve cases. Acta Derm Venereol. 1973. 53(1):71-4. [Medline].

  18. Wood MG, Thew MA. Nevus comedonicus. A case with palmar involvement and review of the literature. Arch Dermatol. 1968 Aug. 98(2):111-6. [Medline].

  19. Kaliyadan F, Nambiar A, Al Ameer A, Amri M. Nevus comedonicus of the scalp. Skinmed. 2014 Jan-Feb. 12(1):59-60. [Medline].

  20. Kikkeri NN, Priyanka R, Parshawanath H. Nevus comedonicus on scalp: a rare site. Indian J Dermatol. 2015 Jan-Feb. 60 (1):105. [Medline].

  21. Abdel-Aal H, Abdel-Aziz AM. Nevus comedonicus. Report of three cases localized on glans penis. Acta Derm Venereol. 1975. 55(1):78-80. [Medline].

  22. Beck MH, Dave VK. Extensive nevus comedonicus. Arch Dermatol. 1980 Sep. 116(9):1048-50. [Medline].

  23. Paige TN, Mendelson CG. Bilateral nevus comedonicus. Arch Dermatol. 1967 Aug. 96(2):172-5. [Medline].

  24. Schecter AK, Lester B, Pan TD, Robinson-Bostom L. Linear nevus comedonicus with epidermolytic hyperkeratosis. J Cutan Pathol. 2004 Aug. 31(7):502-5. [Medline].

  25. Sharma RP, Singh SP. Extensive unilateral nevus comedonicus with bilateral involvement of face. Indian J Dermatol Venereol Leprol. 2001 Jul-Aug. 67(4):195-6. [Medline].

  26. Woods KA, Larcher VF, Harper JI. Extensive naevus comedonicus in a child with Alagille syndrome. Clin Exp Dermatol. 1994 Mar. 19(2):163-4. [Medline].

  27. Bhagwat PV, Tophakhane RS, Rathod RM, Tonita NM, Naidu V. Nevus comedonicus along Blaschko's lines. Indian J Dermatol Venereol Leprol. 2009 May-Jun. 75(3):330. [Medline].

  28. Pavithra S, Pai H, Mallya H, Pai GS. Nevus comedonicus syndrome. Indian J Dermatol. 2011 Nov. 56(6):771-2. [Medline]. [Full Text].

  29. Kaliyadan F, Nampoothiri S, Sunitha V, Kuruvilla VE. Nevus comedonicus syndrome--nevus comedonicus associated with ipsilateral polysyndactyly and bilateral oligodontia. Pediatr Dermatol. 2010 Jul-Aug. 27(4):377-9. [Medline].

  30. Levinsohn JL, Sugarman JL, Yale Center for Mendelian Genomics, McNiff JM, Antaya RJ, Choate KA. Somatic Mutations in NEK9 Cause Nevus Comedonicus. Am J Hum Genet. 2016 May 5. 98 (5):1030-7. [Medline].

  31. Decherd JW, Mills O, Leyden JJ. Naevus comedonicus--treatment with retinoic acid. Br J Dermatol. 1972 May. 86(5):528-9. [Medline].

  32. Milton GP, DiGiovanna JJ, Peck GL. Treatment of nevus comedonicus with ammonium lactate lotion. J Am Acad Dermatol. 1989 Feb. 20(2 Pt 2):324-8. [Medline].

  33. Caers SJ, Van der Geer S, Beverdam EG, Krekels GA, Ostertag JU. Successful treatment of nevus comedonicus with the use of the Erbium Yag laser. J Eur Acad Dermatol Venereol. 2008 Mar. 22(3):375-7. [Medline].

  34. Sardana K, Garg V. Successful treatment of nevus comedonicus with ultrapulse CO2 laser. 2009; 75(5):534-5.

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