Nevus Sebaceus Workup

  • Author: Anwar Al Hammadi, MD, FRCPC; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jun 9, 2010
 

Histologic Findings

The epidermis shows papillomatous hyperplasia. In the dermis, the numbers of mature sebaceous glands are increased. Ectopic apocrine glands are often found in the deep dermis beneath sebaceous glands.

Frequently, small hair follicles and buds of basaloid cells that may represent malformed hair germs are present.

In childhood, the sebaceous glands in nevus sebaceus are underdeveloped, and the histologic findings may consist of only immature hair structures.

Note the images below:

Mild papillomatosis of the epidermis with sebaceusMild papillomatosis of the epidermis with sebaceus gland lobules opening directly onto the epidermis. Mild papillomatosis at high power. Mild papillomatosis at high power.
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Staging

In the early stage, the sebaceous glands and hair follicles are hypoplastic. In the second stage, at puberty, hyperkeratosis and papillomatosis with numerous and hyperplastic sebaceous glands (diagnostic) are present.

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Contributor Information and Disclosures
Author

Anwar Al Hammadi, MD, FRCPC  Consultant and Head of Dermatology, Rashid Hospital, Dubai Health Authority; Clinical Assistant Professor of Dermatology, University of Sharjah, United Arab Emirates

Anwar Al Hammadi, MD, FRCPC is a member of the following medical societies: American Academy of Dermatology, Canadian Dermatology Association, Royal College of Physicians and Surgeons of Canada, and Skin Cancer Foundation

Disclosure: Nothing to disclose.

Coauthor(s)

Mark G Lebwohl, MD  Chairman, Department of Dermatology, Mount Sinai School of Medicine

Mark G Lebwohl, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Abbott Laboratories Honoraria Consulting; Amgen/Pfizer Honoraria Consulting; Astellas Honoraria Consulting; Centocor/Janssen Honoraria Consulting; DermiPsor Honoraria Consulting; GlaxoSmithKline Honoraria Consulting; Graceway Consulting; HelixBioMedix Honoraria Consulting; LEO Honoraria Consulting; Novartis Honoraria Consulting

Specialty Editor Board

Daniel Mark Siegel, MD, MS  Director, Procedural Dermatology Fellowship Program, Clinical Professor of Dermatology, Department of Dermatology, State University of New York Downstate

Daniel Mark Siegel, MD, MS is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Micrographic Surgery and Cutaneous Oncology, American College of Physician Executives, American Society for Dermatologic Surgery, American Society for MOHS Surgery, and International Society for Dermatologic Surgery

Disclosure: Nothing to disclose.

David F Butler, MD  Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Van Perry, MD  Assistant Professor, Department of Medicine, Division of Dermatology, University of Texas Health Science Center

Van Perry, MD is a member of the following medical societies: American Academy of Dermatology and American Society for Laser Medicine and Surgery

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Department of Dermatology, Geisinger Medical Center

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References

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  7. Ivker R, Resnick SD, Skidmore RA. Hypophosphatemic vitamin D-resistant rickets, precocious puberty, and the epidermal nevus syndrome. Arch Dermatol. Dec 1997;133(12):1557-61. [Medline].

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  14. Elghamriny MS. Tumors with sebaceus gland differentiation. In: Ghamriny's Clinical Dermatology. Vol 2. 2000:658-59.

  15. Hamilton KS, Johnson S, Smoller BR. The role of androgen receptors in the clinical course of nevus sebaceus of Jadassohn. Mod Pathol. Jun 2001;14(6):539-42. [Medline].

  16. Happle R. Loss of heterozygosity in human skin. J Am Acad Dermatol. Aug 1999;41(2 Pt 1):143-64. [Medline].

  17. Happle R. Mosaicism in human skin. Understanding the patterns and mechanisms. Arch Dermatol. Nov 1993;129(11):1460-70. [Medline].

  18. Ho VC, Freedberg IM, Eisen AZ, Wolff K. Benign epithelial tumors (nevus sebaceus). In: Fitzpatrick's Dermatology In General Medicine. Vol 1. New York, NY: McGraw-Hill; 1999:878-79.

  19. Lupton JR, Elgart ML, Sulica VI. Segmental neurofibromatosis in association with nevus sebaceus of Jadassohn. J Am Acad Dermatol. Nov 2000;43(5 Pt 2):895-7. [Medline].

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Nevus sebaceus in a 4-month-old baby manifesting as nodular plaque.
Brownish wartlike plaque in a 25-year-old patient.
Nevus sebaceus manifesting as a bald patch in a child.
Nevus sebaceus manifesting as an orange-yellow plaque with a smooth or somewhat velvety surface in a 6-month-old baby.
Nevus sebaceus manifesting as a small plaque beside a scaly scalp in a 13-year-old boy.
Linear type of nevus sebaceus.
Mild papillomatosis of the epidermis with sebaceus gland lobules opening directly onto the epidermis.
Mild papillomatosis at high power.
 
 
 
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