eMedicine Specialties > Dermatology > Benign Neoplasms

Seborrheic Keratosis: Multimedia

Author: Arthur K Balin, MD, PhD, FACP, Clinical Professor, Lankanau Medical Research Center, Jefferson Health System
Contributor Information and Disclosures

Updated: Jan 6, 2009

Multimedia

Sharply circumscribed elevated seborrheic keratos...Media file 1: Sharply circumscribed elevated seborrheic keratoses.
Sharply circumscribed elevated seborrheic keratos...

Sharply circumscribed elevated seborrheic keratoses.

Closer view of multiple seborrheic keratoses in a...Media file 2: Closer view of multiple seborrheic keratoses in an autosomally dominant mode of inheritance.
Closer view of multiple seborrheic keratoses in a...

Closer view of multiple seborrheic keratoses in an autosomally dominant mode of inheritance.

Seborrheic keratoses projecting above the level o...Media file 3: Seborrheic keratoses projecting above the level of the epidermis. Cysts represent sections of hyperkeratotic follicles.
Seborrheic keratoses projecting above the level o...

Seborrheic keratoses projecting above the level of the epidermis. Cysts represent sections of hyperkeratotic follicles.

Seborrheic keratosis showing lackluster surface a...Media file 4: Seborrheic keratosis showing lackluster surface and appearance of being stuck on the skin surface.
Seborrheic keratosis showing lackluster surface a...

Seborrheic keratosis showing lackluster surface and appearance of being stuck on the skin surface.

This is an autosomal dominant form of multiple se...Media file 5: This is an autosomal dominant form of multiple seborrheic keratoses. This man's daughter is developing a similar distribution and quantity of seborrheic keratoses.
This is an autosomal dominant form of multiple se...

This is an autosomal dominant form of multiple seborrheic keratoses. This man's daughter is developing a similar distribution and quantity of seborrheic keratoses.

The back of this same patient as in Media File 5 ...Media file 6: The back of this same patient as in Media File 5 with multiple seborrheic keratoses. His face had a similar number of seborrheic keratoses.
The back of this same patient as in Media File 5 ...

The back of this same patient as in Media File 5 with multiple seborrheic keratoses. His face had a similar number of seborrheic keratoses.

Acanthotic type of seborrheic keratosis.Media file 7: Acanthotic type of seborrheic keratosis.
Acanthotic type of seborrheic keratosis.

Acanthotic type of seborrheic keratosis.

Higher-power view of the cells in an acanthotic s...Media file 8: Higher-power view of the cells in an acanthotic seborrheic keratosis.
Higher-power view of the cells in an acanthotic s...

Higher-power view of the cells in an acanthotic seborrheic keratosis.

Hyperkeratotic type of seborrheic keratosis.Media file 9: Hyperkeratotic type of seborrheic keratosis.
Hyperkeratotic type of seborrheic keratosis.

Hyperkeratotic type of seborrheic keratosis.

Reticulated (or adenoid) type of seborrheic kerat...Media file 10: Reticulated (or adenoid) type of seborrheic keratosis.
Reticulated (or adenoid) type of seborrheic kerat...

Reticulated (or adenoid) type of seborrheic keratosis.

This is a reticulated (or adenoid) seborrheic ker...Media file 11: This is a reticulated (or adenoid) seborrheic keratosis with abundant pigment.
This is a reticulated (or adenoid) seborrheic ker...

This is a reticulated (or adenoid) seborrheic keratosis with abundant pigment.

Seborrheic keratosis with inflammation in the der...Media file 12: Seborrheic keratosis with inflammation in the dermis.
Seborrheic keratosis with inflammation in the der...

Seborrheic keratosis with inflammation in the dermis.

This seborrheic keratosis was a pedunculated lesi...Media file 13: This seborrheic keratosis was a pedunculated lesion in an axillary fold. Clinically, it had some resemblance to a skin tag.
This seborrheic keratosis was a pedunculated lesi...

This seborrheic keratosis was a pedunculated lesion in an axillary fold. Clinically, it had some resemblance to a skin tag.

More on Seborrheic Keratosis

Overview: Seborrheic Keratosis
Differential Diagnoses & Workup: Seborrheic Keratosis
Treatment & Medication: Seborrheic Keratosis
Follow-up: Seborrheic Keratosis
Multimedia: Seborrheic Keratosis
References

References

  1. Ginarte M, Garcia-Caballero T, Fernandez-Redondo V, Beiras A, Toribio J. Expression of growth hormone receptor in benign and malignant cutaneous proliferative entities. J Cutan Pathol. Jul 2000;27(6):276-82. [Medline].

  2. Groves RW, Allen MH, MacDonald DM. Abnormal expression of epidermal growth factor receptor in cutaneous epithelial tumours. J Cutan Pathol. Feb 1992;19(1):66-72. [Medline].

  3. Nanney LB, Ellis DL, Levine J, King LE. Epidermal growth factor receptors in idiopathic and virally induced skin diseases. Am J Pathol. Apr 1992;140(4):915-25. [Medline].

  4. Nakagawa K, Yamamura K, Maeda S, Ichihashi M. bcl-2 expression in epidermal keratinocytic diseases. Cancer. Sep 15 1994;74(6):1720-4. [Medline].

  5. Tojo M, Mori T, Kiyosawa H, Honma Y, Tanno Y, Kanazawa KY, et al. Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma. Pathol Int. Aug 1999;49(8):687-94. [Medline].

  6. Hafner C, Hartmann A, Vogt T. FGFR3 mutations in epidermal nevi and seborrheic keratoses: lessons from urothelium and skin. J Invest Dermatol. Jul 2007;127(7):1572-3. [Medline].

  7. Hafner C, van Oers JM, Hartmann A, Landthaler M, Stoehr R, Blaszyk H, et al. High frequency of FGFR3 mutations in adenoid seborrheic keratoses. J Invest Dermatol. Nov 2006;126(11):2404-7. [Medline].

  8. Hafner C, Hartmann A, Real FX, Hofstaedter F, Landthaler M, Vogt T. Spectrum of FGFR3 mutations in multiple intraindividual seborrheic keratoses. J Invest Dermatol. Aug 2007;127(8):1883-5. [Medline].

  9. Teraki E, Tajima S, Manaka I, Kawashima M, Miyagishi M, Imokawa G. Role of endothelin-1 in hyperpigmentation in seborrhoeic keratosis. Br J Dermatol. Dec 1996;135(6):918-23. [Medline].

  10. Tindall JP, Smith JG Jr. Skin lesions of the aged and their association with internal changes. JAMA. Dec 21 1963;186:1039-42. [Medline].

  11. Memon AA, Tomenson JA, Bothwell J, Friedmann PS. Prevalence of solar damage and actinic keratosis in a Merseyside population. Br J Dermatol. Jun 2000;142(6):1154-9. [Medline].

  12. Williams MG. Acanthomata appearing after eczema. Br J Dermatol. Jul-Aug 1956;68(7):268-71. [Medline].

  13. Yeatman JM, Kilkenny M, Marks R. The prevalence of seborrhoeic keratoses in an Australian population: does exposure to sunlight play a part in their frequency?. Br J Dermatol. Sep 1997;137(3):411-4. [Medline].

  14. Gupta AK, Siegel MT, Noble SC, Kirkby S, Rasmussen JE. Keratoses in patients with psoriasis: a prospective study in fifty-two inpatients. J Am Acad Dermatol. Jul 1990;23(1):52-5. [Medline].

  15. Jacyk WK, Simson IW. Pemphigus erythematosus resembling multiple seborrheic keratoses. Arch Dermatol. Apr 1990;126(4):543-4. [Medline].

  16. Beckmann KR, Kirke BA, McCaul KA, Roder DM. Use of fake tanning lotions in the South Australian population. Med J Aust. Jan 15 2001;174(2):75-8. [Medline].

  17. Kwon OS, Hwang EJ, Bae JH, Park HE, Lee JC, Youn JI, et al. Seborrheic keratosis in the Korean males: causative role of sunlight. Photodermatol Photoimmunol Photomed. Apr 2003;19(2):73-80. [Medline].

  18. Sperry K, Wall J. Adenocarcinoma of the stomach with eruptive seborrheic keratoses: the sign of Leserp-Trelat. Cancer. May 1 1980;45(9):2434-7. [Medline].

  19. Zhu WY, Leonardi C, Kinsey W, Penneys NS. Irritated seborrheic keratoses and benign verrucous acanthomas do not contain papillomavirus DNA. J Cutan Pathol. Dec 1991;18(6):449-52. [Medline].

  20. Li J, Ackerman AB. "Seborrheic keratoses" that contain human papillomavirus are condylomata acuminata. Am J Dermatopathol. Aug 1994;16(4):398-405; discussion 406-8. [Medline].

  21. Lee ES, Whang MR, Kang WH. Absence of human papillomavirus DNA in nongenital seborrheic keratosis. J Korean Med Sci. Oct 2001;16(5):619-22. [Medline].

  22. Liu HN, Chang YT, Chen CC. Differentiation of hidroacanthoma simplex from clonal seborrheic keratosis--an immunohistochemical study. Am J Dermatopathol. Jun 2004;26(3):188-93. [Medline].

  23. Klaus MV, Wehr RF, Rogers RS 3rd, Russell TJ, Krochmal L. Evaluation of ammonium lactate in the treatment of seborrheic keratoses. J Am Acad Dermatol. Feb 1990;22(2 Pt 1):199-203. [Medline].

  24. Van Scott EJ, Yu RJ. Alpha hydroxy acids: procedures for use in clinical practice. Cutis. Mar 1989;43(3):222-8. [Medline].

  25. Herron MD, Bowen AR, Krueger GG. Seborrheic keratoses: a study comparing the standard cryosurgery with topical calcipotriene, topical tazarotene, and topical imiquimod. Int J Dermatol. Apr 2004;43(4):300-2. [Medline].

  26. Braun-Falco O, Weissmann I. [Stuccokeratoses. Review and own observations]. Hautarzt. Nov 1978;29(11):573-7. [Medline].

  27. Cascajo CD, Reichel M, Sanchez JL. Malignant neoplasms associated with seborrheic keratoses. An analysis of 54 cases. Am J Dermatopathol. Jun 1996;18(3):278-82. [Medline].

  28. Di Benedetto G, Pierangeli M, Bertani A. A peculiar case of multiple gigantic seborrheic keratoses. Plast Reconstr Surg. Apr 1997;99(5):1466-7. [Medline].

  29. Eads TJ, Hood AF, Chuang TY, Faust HB, Farmer ER. The diagnostic yield of histologic examination of seborrheic keratoses. Arch Dermatol. Nov 1997;133(11):1417-20. [Medline].

  30. Gill D, Dorevitch A, Marks R. The prevalence of seborrheic keratoses in people aged 15 to 30 years: is the term senile keratosis redundant?. Arch Dermatol. Jun 2000;136(6):759-62. [Medline].

  31. Graham-Brown RA, Berth-Jones J, Dure-Smith B, Naafs B, Pembroke AC, Harth W, et al. Dermatologic problems for immigrant communities in a Western environment. Int J Dermatol. Mar 1990;29(2):94-101. [Medline].

  32. Hairston MA Jr, Reed RJ, Derbes VJ. Dermatosis papulosa nigra. Arch Dermatol. May 1964;89:655-8. [Medline].

  33. Holdiness MR. The sign of Leser-Trelat. Int J Dermatol. Nov 1986;25(9):564-72. [Medline].

  34. Izikson L, Sober AJ, Mihm MC Jr, Zembowicz A. Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases. Arch Dermatol. Dec 2002;138(12):1562-6. [Medline].

  35. Maize JC, Snider RL. Nonmelanoma skin cancers in association with seborrheic keratoses. Clinicopathologic correlations. Dermatol Surg. Nov 1995;21(11):960-2. [Medline].

  36. Mehregan AH. Lentigo senilis and its evolutions. J Invest Dermatol. Nov 1975;65(5):429-33. [Medline].

  37. Mishima Y, Pinkus H. Benign mixed tumor of melanocytes and malpighian cells. Melanoacanthoma: Its relationship to Bloch's benign non-nevoid melanoepithelioma. Arch Dermatol. Apr 1960;81:539-50. [Medline].

  38. Nakamura H, Hirota S, Adachi S, Ozaki K, Asada H, Kitamura Y. Clonal nature of seborrheic keratosis demonstrated by using the polymorphism of the human androgen receptor locus as a marker. J Invest Dermatol. Apr 2001;116(4):506-10. [Medline].

  39. Nindl M, Nakagawa H, Furue M, Ishibashi Y. Simple epithelial cytokeratin-expression in seborrheic keratosis. J Cutan Pathol. Oct 1992;19(5):415-22. [Medline].

  40. Pesce C, Scalora S. Apoptosis in the areas of squamous differentiation of irritated seborrheic keratosis. J Cutan Pathol. Mar 2000;27(3):121-3. [Medline].

  41. Provost N, Kopf AW, Rabinovitz HS, Oliviero MC, Toussaint S, Kamino HH. Globulelike dermoscopic structures in pigmented seborrheic keratosis. Arch Dermatol. Apr 1997;133(4):540-1. [Medline].

  42. Reiches AJ. Seborrheic keratoses; are they delayed hereditary nevi?. AMA Arch Derm Syphilol. May 1952;65(5):596-600. [Medline].

  43. Roncalli de Oliveira W, Neto CF, Rady PL, Tyring SK. Seborrheic Keratosis-like lesions in patients with epidermodysplasia verruciformis. J Dermatol. Jan 2003;30(1):48-53. [Medline].

  44. Shimizu N, Ito M, Tazawa T, Sato Y. Immunohistochemical study on keratin expression in certain cutaneous epithelial neoplasms. Basal cell carcinoma, pilomatricoma, and seborrheic keratosis. Am J Dermatopathol. Dec 1989;11(6):534-40. [Medline].

  45. Soini Y, Kamel D, Pääkkö P, Lehto VP, Oikarinen A, Vähäkangas KV. Aberrant accumulation of p53 associates with Ki67 and mitotic count in benign skin lesions. Br J Dermatol. Oct 1994;131(4):514-20. [Medline].

  46. Tsuji T, Kitajima S, Koashi Y. Expression of proliferating cell nuclear antigen (PCNA) and apoptosis related antigen (LeY) in epithelial skin tumors. Am J Dermatopathol. Apr 1998;20(2):164-9. [Medline].

  47. Unal G. Giant seborrheic keratoses. JEADV VII. Sup 2:s177.

  48. Verhagen AR, Koten JW, Chaddah VK, Patel RI. Skin diseases in Kenya. A clinical and histopathological study of 3,168 patients. Arch Dermatol. Dec 1968;98(6):577-86. [Medline].

  49. Wrone DA, Yoo S, Chipps LK, Moy RL. The expression of p63 in actinic keratoses, seborrheic keratosis, and cutaneous squamous cell carcinomas. Dermatol Surg. Oct 2004;30(10):1299-302. [Medline].

  50. Yamamoto T, Yokoyama A. Hereditary onset of multiple seborrheic keratoses: a variant of Leser Trelat sign?. J Dermatol. Mar 1996;23(3):191-5. [Medline].

  51. Young AW Jr. Dermatogeriatric problems in the chronic disease hospital. N Y State J Med. Jul 1 1965;65:1748-52. [Medline].

Further Reading

Keywords

seborrheic keratoses, seborrheic keratoses, reticulated seborrheic keratosis, dermatosis papulosa nigra, stucco keratosis, melanoacanthoma, skin tags

Contributor Information and Disclosures

Author

Arthur K Balin, MD, PhD, FACP, Clinical Professor, Lankanau Medical Research Center, Jefferson Health System
Arthur K Balin, MD, PhD, FACP is a member of the following medical societies: American Academy of Dermatology, American Chemical Society, American College of Mohs Micrographic Surgery and Cutaneous Oncology, American College of Nutrition, American College of Physicians, American College of Physicians-American Society of Internal Medicine, American Geriatrics Society, American Medical Association, American Society for Clinical Nutrition, American Society for Dermatologic Surgery, American Society for Laser Medicine and Surgery, American Society of Dermatopathology, College of American Pathologists, Gerontological Society of America, International Academy of Pathology, International Society for Dermatologic Surgery, Pennsylvania Medical Society, Phi Beta Kappa, Royal Society of Medicine, Sigma Xi, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.

Medical Editor

Evan R Farmer, MD, Professor of Dermatology, Johns Hopkins University School of Medicine, Clinical Professor of Pathology, Virginia Commonwealth University School of Medicine; Consulting Staff, Department of Dermatology, Johns Hopkins Hospital, VCU Health Services
Evan R Farmer, MD is a member of the following medical societies: American Academy of Dermatology, American Dermatological Association, American Medical Association, American Society of Dermatopathology, and International Society of Dermatology
Disclosure: Nothing to disclose.

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: 3M Pharmaceutical Grant/research funds Other; Graceway Pharmaceuticals Grant/research funds Other

Managing Editor

Warren R Heymann, MD, Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey
Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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