Medscape is available in 5 Language Editions – Choose your Edition here.


Syringoma Differential Diagnoses

  • Author: Christopher R Shea, MD; Chief Editor: Dirk M Elston, MD  more...
Updated: Jun 06, 2016

Diagnostic Considerations

Several cases of syringomalike structures in the dermis of specimens of extramammary Paget disease have been described, and these represent a potential pitfall if misinterpreted as evidence of dermal invasion of the carcinoma cells.[20]

Differential Diagnoses

Contributor Information and Disclosures

Christopher R Shea, MD Professor and Chief, Section of Dermatology, Department of Medicine, University of Chicago, The Pritzker School of Medicine

Christopher R Shea, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society of Dermatopathology, Society for Investigative Dermatology, Association of Professors of Dermatology, International Society of Dermatopathology, Arthur Purdy Stout Society, Chicago Dermatological Society, Dermatology Foundation, Illinois Dermatological Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Michael J Wells, MD, FAAD Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD, FAAD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Texas Medical Association

Disclosure: Nothing to disclose.

Edward F Chan, MD Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania School of Medicine

Edward F Chan, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Robert A Schwartz, MD, MPH Professor and Head of Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, Rutgers New Jersey Medical School; Visiting Professor, Rutgers University School of Public Affairs and Administration

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, New York Academy of Medicine, American Academy of Dermatology, American College of Physicians, Sigma Xi

Disclosure: Nothing to disclose.


Ibiayi Dagogo-Jack University of Chicago Pritzker School of Medicine

Disclosure: Nothing to disclose.

Marcelo G Horenstein, MD, Director of Dermatopathology, The Dermatology Group

Disclosure: Nothing to disclose.

  1. Hashimoto K, Gross BG, Lever WF. Syringoma. Histochemical and electron microscopic studies. J Invest Dermatol. 1966 Feb. 46(2):150-66. [Medline].

  2. Guitart J, Rosenbaum MM, Requena L. Eruptive syringoma': a misnomer for a reactive eccrine gland ductal proliferation?. J Cutan Pathol. 2003 Mar. 30(3):202-5. [Medline].

  3. Marzano AV, Fiorani R, Girgenti V, Crosti C, Alessi E. Familial syringoma: report of two cases with a published work review and the unique association with steatocystoma multiplex. J Dermatol. 2009 Mar. 36(3):154-8. [Medline].

  4. Uede K, Yamamoto Y, Furukawa F. Brooke-Spiegler syndrome associated with cylindroma, trichoepithelioma, spiradenoma, and syringoma. J Dermatol. 2004 Jan. 31(1):32-8. [Medline].

  5. Dupre A, Carrere S, Bonafe JL, Christol B, Lassere J, Touron P. [Eruptive generalized syringomas, milium and atrophoderma vermiculata. Nicolau and Balus' syndrome (author's transl)]. Dermatologica. 1981. 162(4):281-6. [Medline].

  6. Nguyen V, Buka RL, Roberts BJ, Eichenfield LF. Cutaneous manifestations of Costello syndrome. Int J Dermatol. 2007 Jan. 46 (1):72-6. [Medline].

  7. Schepis C, Siragusa M, Palazzo R, Ragusa RM, Massi G, Fabrizi G. Palpebral syringomas and Down's syndrome. Dermatology. 1994. 189(3):248-50. [Medline].

  8. Urban CD, Cannon JR, Cole RD. Eruptive syringomas in Down's syndrome. Arch Dermatol. 1981 Jun. 117(6):374-5. [Medline].

  9. Ong GC, Lim KS, Chian LY. Eruptive syringoma in a patient with trisomy 21. Singapore Med J. 2010 Feb. 51(2):e46-7. [Medline].

  10. Chan S, Millett C, Heymann WR. Giant syringomas: a case report. Cutis. 2012 Jan. 89(1):23-4. [Medline].

  11. Koh MJ. Multiple acral syringomas involving the hands. Clin Exp Dermatol. 2009 Oct. 34(7):e438. [Medline].

  12. Petersson F, Mjornberg PA, Kazakov DV, Bisceglia M. Eruptive syringoma of the penis. A report of 2 cases and a review of the literature. Am J Dermatopathol. 2009 Jul. 31(5):436-8. [Medline].

  13. Sakiyama M, Maeda M, Fujimoto N, Satoh T. Eruptive syringoma localized in intertriginous areas. J Dtsch Dermatol Ges. 2014 Jan. 12(1):72-3. [Medline].

  14. Yung CW, Soltani K, Bernstein JE, Lorincz AL. Unilateral linear nevoidal syringoma. J Am Acad Dermatol. 1981 Apr. 4(4):412-6. [Medline].

  15. Shelley WB, Wood MG. Occult syringomas of scalp associated with progressive hair loss. Arch Dermatol. 1980 Jul. 116(7):843-4. [Medline].

  16. Hamsch C, Hartschuh W. Microcystic adnexal carcinoma - aggressive infiltrative tumor often with innocent clinical appearance. J Dtsch Dermatol Ges. 2009 Sep 25. [Medline].

  17. Wallace JS, Bond JS, Seidel GD, Samie FH. An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. Dermatol Surg. 2014 Jul. 40(7):810-2. [Medline].

  18. Kao PH, Hsu CK, Lee JY. Clinicopathological study of Fox-Fordyce disease. J Dermatol. 2009 Sep. 36(9):485-90. [Medline].

  19. Jeon EK, Cho AY, Lee Y, Seo YJ, Park JK, Lee JH. Multiple yellow-brown papules on the neck and anterior trunk of a patient with diabetes mellitus. Clin Exp Dermatol. 2009 Jul. 34(5):643-4. [Medline].

  20. Konstantinova AM, Hayes MM, Stewart CJ, Plaza JA, Michal M, Kerl K, et al. Syringomatous Structures in Extramammary Paget Disease: A Potential Diagnostic Pitfall. Am J Dermatopathol. 2016 Feb 9. [Medline].

  21. Mitkov M, Balagula Y, Taube JM, Lockshin B. Plaque-like syringoma with involvement of deep reticular dermis. J Am Acad Dermatol. 2014 Nov. 71 (5):e206-7. [Medline].

  22. Eckert F, Nilles M, Schmid U, Altmannsberger M. Distribution of cytokeratin polypeptides in syringomas. An immunohistochemical study on paraffin-embedded material. Am J Dermatopathol. 1992 Apr. 14(2):115-21. [Medline].

  23. Jamalipour M, Heidarpour M, Rajabi P. Generalized eruptive syringomas. Indian J Dermatol. 2009. 54(1):65-7. [Medline]. [Full Text].

  24. Al Aradi IK. Periorbital syringoma: a pilot study of the efficacy of low-voltage electrocoagulation. Dermatol Surg. 2006 Oct. 32(10):1244-50. [Medline].

  25. Park HJ, Lee DY, Lee JH, Yang JM, Lee ES, Kim WS. The treatment of syringomas by CO2 laser using a multiple-drilling method. Dermatol Surg. 2007 Mar. 33(3):310-3. [Medline].

  26. Wang JI, Roenigk HH Jr. Treatment of multiple facial syringomas with the carbon dioxide (CO2) laser. Dermatol Surg. 1999 Feb. 25(2):136-9. [Medline].

  27. Cho SB, Lee SH, Lee SJ, Lee JE, Kim DH. Syringoma treated with pinhole method. J Eur Acad Dermatol Venereol. 2009 Jul. 23(7):852-3. [Medline].

  28. Cho SB, Kim HJ, Noh S, Lee SJ, Kim YK, Lee JH. Treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser: a prospective analysis of 35 patients. Dermatol Surg. 2011 Apr. 37(4):433-8. [Medline].

The multiple, small, yellow papules in the lower lid and upper part of the cheek correspond to syringomas. The blue cyst in the inner canthus is an eccrine hidrocystoma. Courtesy of Mark S. Brown, MD, University of South Alabama Medical Center.
Eruptive syringomas.
Histologic section of syringoma demonstrates numerous small ducts in a sclerotic stroma. Note the tadpole-shaped ducts.
Histologic section of clear-cell syringoma.
All material on this website is protected by copyright, Copyright © 1994-2016 by WebMD LLC. This website also contains material copyrighted by 3rd parties.