- Author: Craig G Burkhart, MD, MPH; Chief Editor: Dirk M Elston, MD more...
Folliculomas are not associated with complications, and cancerous tendencies have not been reported; they are completely benign growths.
Folliculomas are benign asymptomatic lesions that may present as a cosmetic problem. Clinically, they are more likely to be confused with a more serious entity, ie, basal cell carcinoma; however, they have no malignant potential. Prognosis of folliculomas is excellent because it has no sinister sequelae. Recurrence can occur if the lesion is not totally removed on excision.
Patients need to know that these lesions are totally benign and require no follow-up care. The lesion may need to be excised to confirm the diagnosis. Lesions may recur if not totally removed.
Cole P, Kaufman Y, Dishop M, Hatef DA, Hollier L. Giant, congenital folliculosebaceous cystic hamartoma: a case against a pathogenetic relationship with trichofolliculoma. Am J Dermatopathol. 2008 Oct. 30(5):500-3. [Medline].
Schulz T, Hartschuh W. Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage. J Cutan Pathol. 1998 Aug. 25(7):354-64. [Medline].
Kurokawa I, Kusumoto K, Sensaki H, Shikata N, Tsubura A, Nishijima S. Trichofolliculoma: case report with immunohistochemical study of cytokeratins. Br J Dermatol. 2003 Mar. 148(3):597-8. [Medline].
Ishii N, Kawaguchi H, Takahashi K, Nakajima H. A case of congenital trichofolliculoma. J Dermatol. 1992 Mar. 19(3):195-6. [Medline].
Peterdy GA, Huettner PC, Rajaram V, Lind AC. Trichofolliculoma of the vulva associated with vulvar intraepithelial neoplasia: report of three cases and review of the literature. Int J Gynecol Pathol. 2002 Jul. 21(3):224-30. [Medline].
Bogle MA, Cohen PR, Tschen JA. Trichofolliculoma with incidental focal acantholytic dyskeratosis. South Med J. 2004 Aug. 97(8):773-5. [Medline].
Mizutani H, Senga K, Ueda M. Trichofolliculoma of the upper lip: report of a case. Int J Oral Maxillofac Surg. 1999 Apr. 28(2):135-6. [Medline].
Hartschuh W, Schulz T. Immunohistochemical investigation of the different developmental stages of trichofolliculoma with special reference to the Merkel cell. Am J Dermatopathol. 1999 Feb. 21(1):8-15. [Medline].
Manabe M, Yaguchi H, Iqbal Butt K, O'Guin WM, Loomis CA, Sung TT, et al. Trichohyalin expression in skin tumors: retrieval of trichohyalin antigenicity in tissues by microwave irradiation. Int J Dermatol. 1996 May. 35(5):325-9. [Medline].
Zimmermann T, Hartschuh W, Raulin C. [Facial folliculo-sebaceous cystic hamartoma. Treatment with CO2 and Er:YAG lasers]. Hautarzt. 2004 Mar. 55(3):289-91. [Medline].
Morton AD, Nelson CC, Headington JT, Elner VM. Recurrent trichofolliculoma of the upper eyelid margin. Ophthal Plast Reconstr Surg. 1997 Dec. 13(4):287-8. [Medline].
Gray HR, Helwig EB. Trichofolliculoma. Arch Dermatol. 1962. 86:619-25.
Miescher G. Trichofolliculoma. Dermatologica. 1944. 89:193-194.