eMedicine Specialties > Dermatology > Benign Neoplasms

Warty Dyskeratoma: Differential Diagnoses & Workup

Author: Molly Hinshaw, MD, Assistant Professor, Department of Dermatology, University of Wisconsin School of Medicine and Public Health
Contributor Information and Disclosures

Updated: Mar 10, 2009

Differential Diagnoses

Actinic Keratosis
Familial Benign Pemphigus (Hailey-Hailey Disease)
Keratoacanthoma
Keratosis Follicularis (Darier Disease)
Squamous Cell Carcinoma

Other Problems to Be Considered

Grover disease
Linear epidermal nevus

Workup

Laboratory Studies

Because warty dyskeratoma has repeatedly been shown to be a lesion not associated with systemic disease, no laboratory studies are necessary.

Imaging Studies

No imaging studies are necessary.

Procedures

A biopsy specimen interpreted by a dermatopathologist is the criterion standard for diagnosis.

Histologic Findings

The pathologic process is that of a well-circumscribed endophytic or endo-exophytic epithelial proliferation of benign squamous cells demonstrating elongated dermal papillae (villi) with suprabasilar acantholysis and dyskeratotic cells. Dyskeratotic cells are referred to as corps ronds and grains. A central keratin-filled invagination may be identified. The lesion can sometimes be seen originating from a hair follicle or sebaceous gland. 

Warty dyskeratoma. An endo-exophytic squamous pro...

Warty dyskeratoma. An endo-exophytic squamous proliferation of cytologically benign, acantholytic, and dyskeratotic keratinocytes.

Warty dyskeratoma. An endo-exophytic squamous pro...

Warty dyskeratoma. An endo-exophytic squamous proliferation of cytologically benign, acantholytic, and dyskeratotic keratinocytes.


Villi lined by acantholytic keratinocytes, some o...

Villi lined by acantholytic keratinocytes, some of which are dyskeratotic (corps ronds and corps grains).

Villi lined by acantholytic keratinocytes, some o...

Villi lined by acantholytic keratinocytes, some of which are dyskeratotic (corps ronds and corps grains).


Staging

Staging is not necessary for this benign lesion.

More on Warty Dyskeratoma

Overview: Warty Dyskeratoma
Differential Diagnoses & Workup: Warty Dyskeratoma
Treatment & Medication: Warty Dyskeratoma
Follow-up: Warty Dyskeratoma
Multimedia: Warty Dyskeratoma
References

References

  1. Tuominen H, Sormunen R, Kallioinen M. Non-erythroid spectrin (fodrin) in cutaneous tumours: diminished in cell membranes, increased in the cytoplasm. Br J Dermatol. Oct 1996;135(4):576-80. [Medline].

  2. Kaugars GE, Lieb RJ, Abbey LM. Focal oral warty dyskeratoma. Int J Dermatol. Mar 1984;23(2):123-30. [Medline].

  3. Azuma Y, Matsukawa A. Warty dyskeratoma with multiple lesions. J Dermatol. Jun 1993;20(6):374-7. [Medline].

  4. Duray PH, Merino MJ, Axiotis C. Warty dyskeratoma of the vulva. Int J Gynecol Pathol. 1983;2(3):286-93. [Medline].

  5. Griffiths TW, Hashimoto K, Sharata HH, Ellis CN. Multiple warty dyskeratomas of the scalp. Clin Exp Dermatol. Jul 1997;22(4):189-91. [Medline].

  6. Heymann WR. Warty dyskeratoma appearing in a patient with Darier's disease. Int J Dermatol. Sep 1988;27(7):521-2. [Medline].

  7. Kaddu S, Dong H, Mayer G, Kerl H, Cerroni L. Warty dyskeratoma--"follicular dyskeratoma": analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm. J Am Acad Dermatol. Sep 2002;47(3):423-8. [Medline].

  8. Baran R, Perrin C. Focal subungual warty dyskeratoma. Dermatology. 1997;195(3):278-80. [Medline].

  9. Szymanski FJ. Warty dyskeratoma; a benign cutaneous tumor resembling Darier's disease microscopically. AMA Arch Derm. Apr 1957;75(4):567-72. [Medline].

  10. Brownstein MH. The benign acanthomas. J Cutan Pathol. Jun-Aug 1985;12(3-4):172-88. [Medline].

  11. Harrist TJ, Murphy EF, Mihm MC. Oral warty dyskeartoma. Arch Dermatol. 1980;116:929.

Further Reading

Keywords

warty dyskeratoma, WD, focal acantholytic dyskeratosis, isolated keratosis follicularis, Darier disease, Grover disease

Contributor Information and Disclosures

Author

Molly Hinshaw, MD, Assistant Professor, Department of Dermatology, University of Wisconsin School of Medicine and Public Health
Molly Hinshaw, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Women's Dermatologic Society
Disclosure: Nothing to disclose.

Medical Editor

Timothy McCalmont, MD, Director, UCSF Dermatopathology Service, Professor of Clinical Pathology and Dermatology, Departments of Pathology and Dermatology, University of California at San Francisco
Timothy McCalmont, MD is a member of the following medical societies: Alpha Omega Alpha, American Medical Association, American Society of Dermatopathology, California Medical Association, College of American Pathologists, and United States and Canadian Academy of Pathology
Disclosure: Apsara Consulting fee Independent contractor

Pharmacy Editor

Richard P Vinson, MD, Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA
Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Rosalie Elenitsas, MD, Herman Beerman Associate Professor of Dermatology, University of Pennsylvania School of Medicine; Director, Penn Cutaneous Pathology Services, Department of Dermatology, University of Pennsylvania Health System
Rosalie Elenitsas, MD is a member of the following medical societies: American Academy of Dermatology and American Society of Dermatopathology
Disclosure: Nothing to disclose.

CME Editor

Joel M Gelfand, MD, MSCE, Medical Director, Clinical Studies Unit, Assistant Professor, Department of Dermatology, Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
Joel M Gelfand, MD, MSCE is a member of the following medical societies: Society for Investigative Dermatology
Disclosure: AMGEN Consulting fee Consulting; AMGEN Grant/research funds None; Genentech Consulting fee Consulting; Centocor Consulting fee Consulting; Centocor Grant/research funds None; Covance Consulting fee Consulting; Shire  Consulting

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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