eMedicine Specialties > Dermatology > Benign Neoplasms
Warty Dyskeratoma: Differential Diagnoses & Workup
Updated: Mar 10, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Differential Diagnoses
Actinic Keratosis
Familial Benign Pemphigus (Hailey-Hailey
Disease)
Keratoacanthoma
Keratosis Follicularis (Darier Disease)
Squamous Cell Carcinoma
Other Problems to Be Considered
Grover disease
Linear epidermal nevus
Workup
Laboratory Studies
Because warty dyskeratoma has repeatedly been shown to be a lesion not associated with systemic disease, no laboratory studies are necessary.
Imaging Studies
No imaging studies are necessary.
Procedures
A biopsy specimen interpreted by a dermatopathologist is the criterion standard for diagnosis.
Histologic Findings
The pathologic process is that of a well-circumscribed endophytic or endo-exophytic epithelial proliferation of benign squamous cells demonstrating elongated dermal papillae (villi) with suprabasilar acantholysis and dyskeratotic cells. Dyskeratotic cells are referred to as corps ronds and grains. A central keratin-filled invagination may be identified. The lesion can sometimes be seen originating from a hair follicle or sebaceous gland.
Warty dyskeratoma. An endo-exophytic squamous proliferation of cytologically benign, acantholytic, and dyskeratotic keratinocytes.
Villi lined by acantholytic keratinocytes, some of which are dyskeratotic (corps ronds and corps grains).
Staging
Staging is not necessary for this benign lesion.
More on Warty Dyskeratoma |
| Overview: Warty Dyskeratoma |
Differential Diagnoses & Workup: Warty Dyskeratoma |
| Treatment & Medication: Warty Dyskeratoma |
| Follow-up: Warty Dyskeratoma |
| Multimedia: Warty Dyskeratoma |
| References |
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References
Tuominen H, Sormunen R, Kallioinen M. Non-erythroid spectrin (fodrin) in cutaneous tumours: diminished in cell membranes, increased in the cytoplasm. Br J Dermatol. Oct 1996;135(4):576-80. [Medline].
Kaugars GE, Lieb RJ, Abbey LM. Focal oral warty dyskeratoma. Int J Dermatol. Mar 1984;23(2):123-30. [Medline].
Azuma Y, Matsukawa A. Warty dyskeratoma with multiple lesions. J Dermatol. Jun 1993;20(6):374-7. [Medline].
Duray PH, Merino MJ, Axiotis C. Warty dyskeratoma of the vulva. Int J Gynecol Pathol. 1983;2(3):286-93. [Medline].
Griffiths TW, Hashimoto K, Sharata HH, Ellis CN. Multiple warty dyskeratomas of the scalp. Clin Exp Dermatol. Jul 1997;22(4):189-91. [Medline].
Heymann WR. Warty dyskeratoma appearing in a patient with Darier's disease. Int J Dermatol. Sep 1988;27(7):521-2. [Medline].
Kaddu S, Dong H, Mayer G, Kerl H, Cerroni L. Warty dyskeratoma--"follicular dyskeratoma": analysis of clinicopathologic features of a distinctive follicular adnexal neoplasm. J Am Acad Dermatol. Sep 2002;47(3):423-8. [Medline].
Baran R, Perrin C. Focal subungual warty dyskeratoma. Dermatology. 1997;195(3):278-80. [Medline].
Szymanski FJ. Warty dyskeratoma; a benign cutaneous tumor resembling Darier's disease microscopically. AMA Arch Derm. Apr 1957;75(4):567-72. [Medline].
Brownstein MH. The benign acanthomas. J Cutan Pathol. Jun-Aug 1985;12(3-4):172-88. [Medline].
Harrist TJ, Murphy EF, Mihm MC. Oral warty dyskeartoma. Arch Dermatol. 1980;116:929.
Further Reading
Keywords
warty dyskeratoma, WD, focal acantholytic dyskeratosis, isolated keratosis follicularis, Darier disease, Grover disease




Differential Diagnoses & Workup: Warty Dyskeratoma