Multinucleate cell angiohistiocytoma has not been shown to respond to any medical therapy.
Surgical excision of multinucleate cell angiohistiocytoma may be recommended for cosmetic reasons.
Laser therapy has resulted in clinical resolution of the lesions with not scarring. Kopera et al reported successful treatment with an argon laser.  Richer and Lui reported successful treatment with a 585-nm pulsed dye laser. 
Treatment using intense pulsed light has also been reported. 
Further follow-up care is not needed because multinucleate cell angiohistiocytoma is not known to be associated with any systemic diseases and because it has a biologically benign course.