Bullous Disease of Diabetes Clinical Presentation
- Author: Maureen B Poh-Fitzpatrick, MD; Chief Editor: Dirk M Elston, MD more...
Bullous disease of diabetes (bullosis diabeticorum) blisters occur spontaneously and abruptly, often overnight, and usually without known antecedent trauma.
These blisters tend to be asymptomatic, although mild discomfort or burning has been described.
Bullous disease of diabetes blisters heal spontaneously within 2-6 weeks of onset.
The goals of the physical examination should include determining the location and physical characteristics of lesions, developing a useful differential diagnosis, and determining the need for biopsy to secure a correct diagnosis and for culture to identify secondary infections that may require treatment.
Common findings of bullous disease of diabetes (bullosis diabeticorum) include tense, nontender blisters arising on nonerythematous skin (see the image below).
Blisters tend to be large (from 0.5-17 cm in diameter), often with an irregular shape, simulating a burn. Some blisters may also be flaccid. Although blisters typically occur on the feet or lower legs, they also may occur on fingers, toes, hands, and arms. (See the image below.)
Rarely, nonacral sites (eg, trunk) may be involved.
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