eMedicine Specialties > Dermatology > Connective Tissue Diseases

Lupus Erythematosus, Drug-Induced: Follow-up

Author: Catharine Lisa Kauffman, MD, FACP, Georgetown Dermatology and Georgetown Dermpath
Coauthor(s): Arden E Fredeking, Georgetown University School of Medicine
Contributor Information and Disclosures

Updated: Aug 7, 2009

Follow-up

Further Outpatient Care

  • In patients with drug-induced lupus erythematosus (DILE), monitor antinuclear antibody levels, anti-ssDNA, anti-dsDNA, antihistone antibody levels, serum complement levels, and urinalysis findings.
  • Continue to monitor cardiac, renal, and pulmonary function if any of these were initially involved.

Complications

  • In rare instances, patients may die of renal involvement.

Prognosis

  • Prognosis is excellent once the causative medication is discontinued. Recovery generally occurs within days or weeks.

Patient Education

Miscellaneous

Medicolegal Pitfalls

  • Failure to diagnose renal involvement: Death from drug-induced lupus erythematosus (DILE) is extremely rare but may result from renal involvement (eg, membranous proliferative and necrotizing glomerulonephritis)
 


More on Lupus Erythematosus, Drug-Induced

Overview: Lupus Erythematosus, Drug-Induced
Differential Diagnoses & Workup: Lupus Erythematosus, Drug-Induced
Treatment & Medication: Lupus Erythematosus, Drug-Induced
Follow-up: Lupus Erythematosus, Drug-Induced
Multimedia: Lupus Erythematosus, Drug-Induced
References

References

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Further Reading

Keywords

drug-related lupus, lupuslike syndrome, lupus-like syndrome, lupus erythematosus medicamentosus, drug-induced systemic lupus erythematosus, SLE, drug-induced SLE, drug-induced systemic lupus erythematosus, renal idiopathic lupus, DILE, LE, drug-induced LE, autoimmune disease,  procainamide, chlorpromazine, quinidine, acebutolol, amiodarone, bupropion, captopril, carbamazepine, chlorpromazine, diltiazem, docetaxel, ethosuximide, gemfibrozil, glyburide, gold salt, griseofulvin, hydantoins, hydralazine, hydroxychloroquine, interferons

interleukins, isoniazid, leuprolide acetate, lithium, lovastatin, mephenytoin, methyldopa, minocycline, nitrofurantoin, olanzapine, ophthalmic timolol, oral contraceptives, penicillamine, phenytoin, practolol, procainamide, propylthiouracil, quinidine, reserpine, rifampin, simvastatin, sulfasalazine, tetracycline, ticlopidine, tiotropium bromide inhaler, trimethadione, tumor necrosis factor, valproate, voriconazole, cimedtidine, hydralazine, hydrochlorothiazide, mesantoin, PABA, penicillin, phenylbutazone, sulfonamides, terbinafine, arthralgia, treatment, diagnosis

Contributor Information and Disclosures

Author

Catharine Lisa Kauffman, MD, FACP, Georgetown Dermatology and Georgetown Dermpath
Catharine Lisa Kauffman, MD, FACP is a member of the following medical societies: American Academy of Dermatology, American Medical Association, Royal Society of Medicine, Society for Investigative Dermatology, and Women's Dermatologic Society
Disclosure: Nothing to disclose.

Coauthor(s)

Arden E Fredeking, Georgetown University School of Medicine
Arden E Fredeking is a member of the following medical societies: American Medical Student Association/Foundation
Disclosure: Nothing to disclose.

Medical Editor

Craig A Elmets, MD, Director of Dermatology, Departments of Dermatology, Pathology, and Environmental Health Sciences; Professor, The Kirklin Clinic, University of Alabama at Birmingham
Craig A Elmets, MD is a member of the following medical societies: American Academy of Dermatology, American Association of Immunologists, American College of Physicians, American Federation for Medical Research, and Society for Investigative Dermatology
Disclosure: Palomar Medical Technologies Stock None; Amgen Consulting fee Review panel membership; Astellas Consulting fee Review panel membership; Massachusetts Medical Society Salary Employment; Abbott Laboratories Grant/research funds Independent contractor

Pharmacy Editor

Michael J Wells, MD, Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center
Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Jeffrey P Callen, MD, Professor of Medicine, Chief, Division of Dermatology, University of Louisville School of Medicine
Jeffrey P Callen, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and American College of Rheumatology
Disclosure: Amgen Honoraria Consulting; Abbott Honoraria Consulting; Electrical Optical Sciences Honoraria Consulting; Centocor Honoraria Consulting; Medicis Honoraria Consulting; Celgene Honoraria Consulting

CME Editor

Glen H Crawford, MD, Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital
Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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