Dermatologic Manifestations of Eosinophilic Fasciitis Workup

  • Author: Brad S Graham, MD; Chief Editor: William D James, MD   more...
 
Updated: Aug 16, 2011
 

Laboratory Studies

  • CBC count shows eosinophilia (10-40%) in as many as 80-90% of patients. In addition, pancytopenia, anemia, or thrombocytopenia may be encountered in eosinophilic fasciitis.
  • The erythrocyte sedimentation rate is elevated in as many as 60-80% of eosinophilic fasciitis patients.
  • Immunoglobulin levels show hypergammaglobulinemia, usually polyclonal immunoglobulin G.
  • Muscle enzyme levels are sometimes elevated, especially aldolase.
  • The antinuclear antibody result is occasionally positive.
  • The rheumatoid factor result is occasionally positive.
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Imaging Studies

  • If clinically indicated, MRI of the involved areas shows a high-intensity signal in the fascia. A 2005 study demonstrated that MRI shows characteristic findings of fascial thickening, abnormal signal intensity, and contrast enhancement. According to the authors, these findings are useful to make the diagnosis, to guide the location for biopsy, and to monitor the response to therapy.[14]
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Other Tests

  • If clinically indicated, electromyograms may show slow motor unit potentials with reduced duration and amplitude consistent with a myositis.
  • Pulmonary function test results may show a restrictive pattern with severe truncal involvement.
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Procedures

  • If abnormal values other than eosinophilia are found on the CBC count, a bone marrow examination may be necessary.
  • A full-thickness incisional biopsy that includes the dermis, the subcutaneous fat, and the fascia is necessary to confirm a diagnosis of eosinophilic fasciitis.
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Histologic Findings

The most profound changes associated with eosinophilic fasciitis occur in the superficial fascia, which is markedly thickened, fibrosed, and sclerotic. In the early stages, fibrinoid necrosis or myxoid degeneration may be seen. The fibrosis extends into the septae of the subcutaneous fat, which entrap the fat within intersecting bands of fibrosis. The fibrotic process also extends into the lower dermis and the underlying musculature. The muscle may show focal necrosis, degeneration, and regeneration.

The inflammatory infiltrate is usually mild to moderate and consists of lymphocytes, histiocytes, plasma cells, and variable numbers of eosinophils. Eosinophils are not required to make the diagnosis; the term eosinophilic fasciitis refers to peripheral eosinophilia not tissue eosinophilia. The inflammatory infiltrate, including lymphoid follicles, involves the lower dermis, the septae, the fascia, and the muscle. The epidermis, the papillary dermis, and the adnexa are usually spared. On direct immunofluorescence, immunoglobulin M is found at the dermal-epidermal junction, and immunoglobulin G and C3 are found around blood vessels in the lower dermis, the fascia, and the skeletal muscle.

Note the marked thickening and replacement of the Note the marked thickening and replacement of the entire dermis with sclerotic collagen on this incisional biopsy sample from the left posterior part of the thigh. Photomicrograph of subcutaneous fat-fascia junctioPhotomicrograph of subcutaneous fat-fascia junction shows entrapment of subcutaneous fat by intersecting thick bands of fibrosis. Thickening and fibrosis of fascia and lymphoid aggregates are seen. Photomicrograph of fascia-skeletal muscle junctionPhotomicrograph of fascia-skeletal muscle junction shows markedly thickened fascia with heavy inflammatory infiltration. High-power photomicrograph of fascia shows heavy iHigh-power photomicrograph of fascia shows heavy inflammatory infiltration with numerous eosinophils, lymphocytes, and occasional plasma cells.
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Contributor Information and Disclosures
Author

Brad S Graham, MD  Consulting Staff, Dermatology Associates of Tyler

Brad S Graham, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, and Texas Dermatological Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Ponciano D Cruz Jr, MD  Vice-Chair, JB Shelmire Professor, Department of Dermatology, University of Texas Southwestern Medical Center

Ponciano D Cruz Jr, MD is a member of the following medical societies: Texas Medical Association

Disclosure: RCTS Consulting fee Independent contractor; Mary Kay Cosmetics Honoraria Consulting; Galderma Grant/research funds Principal Investigator

David F Butler, MD  Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic

David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Edward F Chan, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania School of Medicine

Edward F Chan, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD  Paul R Gross Professor of Dermatology, University of Pennsylvania School of Medicine; Vice-Chair, Program Director, Department of Dermatology, University of Pennsylvania Health System

William D James, MD is a member of the following medical societies: American Academy of Dermatology and Society for Investigative Dermatology

Disclosure: Elsevier Royalty Other

References

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  2. Serrano-Grau P, Mascaró-Galy JM, Iranzo P. Eosinophilic fasciitis after taking simvastatin. Actas Dermosifiliogr. Jun 2008;99(5):420-1. [Full Text].

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  4. Jinnin M, Ihn H, Yazawa N, Asano Y, Yamane K, Tamaki K. Elevated serum levels of manganese superoxide dismutase in patients with eosinophilic fasciitis. Clin Rheumatol. Dec 2003;22(6):505. [Medline].

  5. Jinnin M, Ihn H, Yamane K, Asano Y, Yazawa N, Tamaki K. Serum levels of tissue inhibitor of metalloproteinase-1 and 2 in patients with eosinophilic fasciitis. Br J Dermatol. Aug 2004;151(2):407-12. [Medline].

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Lower back part of the legs shows hypopigmentation, induration, biopsy site, and asymmetric involvement.
Posterior thigh shows woody induration, sclerosis, and hypopigmentation.
Close-up view of left posterior thigh 2 weeks later shows erythema, scaling, alopecia, and rippled induration.
Posterior part of the calf in the first week of illness shows erythema, edema, alopecia, scaling, and early induration. The right calf is relatively uninvolved with patchy erythema only.
Photograph of the posterior part of the calf at 3 weeks shows complete sclerosis and induration with patchy erythema.
Note the marked thickening and replacement of the entire dermis with sclerotic collagen on this incisional biopsy sample from the left posterior part of the thigh.
Photomicrograph of subcutaneous fat-fascia junction shows entrapment of subcutaneous fat by intersecting thick bands of fibrosis. Thickening and fibrosis of fascia and lymphoid aggregates are seen.
Photomicrograph of fascia-skeletal muscle junction shows markedly thickened fascia with heavy inflammatory infiltration.
High-power photomicrograph of fascia shows heavy inflammatory infiltration with numerous eosinophils, lymphocytes, and occasional plasma cells.
 
 
 
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