Scleredema Medication

  • Author: Misha A Rosenbach, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jun 17, 2010
 
 

Medication Summary

No therapy is consistently effective for scleredema. A number of therapies, including systemic steroids, cyclosporine,[22] methotrexate, high-dose penicillin,[15] UVA1 phototherapy,[23] psoralen with ultraviolet light A (PUVA) either administered systemically or via cream[24] or bath therapy,[25] penicillamine, electron beam,[12, 26] and glycemic control with prostaglandin E 1 (PGE 1 ),[14] have all been tried with limited success.

In cases associated with myeloma, chemotherapy directed at the hematologic malignancy has been reported to result in concomitant improvement of the skin disease.[18] For patients with paraproteinemia, extracorporeal photophoresis has been used.[27]

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Contributor Information and Disclosures
Author

Misha A Rosenbach, MD  Assistant Professor, Departments of Medicine and Dermatology, Hospital of the University of Pennsylvania

Misha A Rosenbach, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Academy, Medical Dermatology Society, and Women's Dermatologic Society

Disclosure: Centocor Grant/research funds None

Coauthor(s)

Victoria P Werth, MD  Professor of Dermatology and Medicine, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, Philadelphia Veterans Affairs Medical Center

Victoria P Werth, MD is a member of the following medical societies: American Academy of Dermatology, American College of Physicians, American College of Rheumatology, Medical Dermatology Society, Phi Beta Kappa, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Susan M Swetter, MD  Director, Pigmented Lesion and Cutaneous Melanoma Clinic, Professor, Department of Dermatology, Stanford University Medical Center, Veterans Affairs Palo Alto Health Care System

Susan M Swetter, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society of Clinical Oncology, Eastern Cooperative Oncology Group, Pacific Dermatologic Association, Society for Investigative Dermatology, Society for Melanoma Research, and Women's Dermatologic Society

Disclosure: Nothing to disclose.

Richard P Vinson, MD  Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Lester F Libow, MD  Dermatopathologist, South Texas Dermatopathology Laboratory

Lester F Libow, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Texas Medical Association

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Department of Dermatology, Geisinger Medical Center

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References

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  2. Sansom JE, Sheehan AL, Kennedy CT, Delaney TJ. A fatal case of scleredema of Buschke. Br J Dermatol. May 1994;130(5):669-70. [Medline].

  3. Rimon D, Lurie M, Storch S, et al. Cardiomyopathy and multiple myeloma. Complications of scleredema adultorum. Arch Intern Med. Mar 1988;148(3):551-3. [Medline].

  4. Ioannidou DI, Krasagakis K, Stefanidou MP, Karampekios S, Panayiotidis J, Tosca AD. Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge. J Am Acad Dermatol. Feb 2005;52(2 Suppl 1):41-4. [Medline].

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  12. Angeli-Besson C, Koeppel MC, Jacquet P, Andrac L, Sayag J. Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia. Br J Dermatol. Mar 1994;130(3):394-7. [Medline].

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  14. Ikeda Y, Suehiro T, Abe T, et al. Severe diabetic scleredema with extension to the extremities and effective treatment using prostaglandin E1. Intern Med. Oct 1998;37(10):861-4. [Medline].

  15. Krasagakis K, Hettmannsperger U, Trautmann C, Tebbe B, Garbe C. Persistent scleredema of Buschke in a diabetic: improvement with high-dose penicillin. Br J Dermatol. Mar 1996;134(3):597-8. [Medline].

  16. Rota E, Nallino MG, Bainotti S, Formica M. Nephrogenic systemic fibrosis: an unusual scleroderma-like fibrosing disorder. Rheumatol Int. Aug 20 2009;[Medline].

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  24. Grundmann-Kollmann M, Ochsendorf F, Zollner TM, Spieth K, Kaufmann R, Podda M. Cream PUVA therapy for scleredema adultorum. Br J Dermatol. May 2000;142(5):1058-9. [Medline].

  25. Hager CM, Sobhi HA, Hunzelmann N, et al. Bath-PUVA therapy in three patients with scleredema adultorum. J Am Acad Dermatol. Feb 1998;38(2 Pt 1):240-2. [Medline].

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  28. Maize J, Metcalf J. Metabolic diseases of the skin. In: Lever WF, Elenitsas R, Jaworsky C, Johnson B, eds. Lever's Histopathology of the Skin. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 1997.

 
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Middle-aged man who has diabetes with scleredema on the upper part of the back.
Middle-aged man who has diabetes with scleredema on the upper part of the back.
 
 
 
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