Idiopathic Guttate Hypomelanosis Treatment & Management
- Author: Christopher R Gorman, MD; Chief Editor: William D James, MD more...
Medical therapy for idiopathic guttate hypomelanosis includes corticosteroids, either topical or intralesional, and retinoids, typically topical tretinoin. One report describes successful treatment with pimecrolimus 1% ; however, caution is warranted because the author has anecdotal experience possibly suggesting that topical calcineurin inhibitors may be linked to the development of idiopathic guttate hypomelanosis in immunosuppressed patients. Another described successful treatment with topical tacrolimus, but results were not statistically significant after clinical assessments.
Surgical techniques, from cryosurgery to dermabrasion, have been tried for idiopathic guttate hypomelanosis, with some success. Theoretically, cryotherapy would remove the damaged melanocytes, which would encourage normal melanocytes to replace them. Fractional carbon dioxide laser and nonablative fractional photothermolysis treatment have been reported as safe and effective.[13, 14, 15] The use of a spot 88% phenol peel is another option; however, persistent scabbing and hyperpigmentation are potential adverse effects.
In doubtful cases, a consultation with a dermatologist should precede any laboratory or biopsy studies.
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