eMedicine Specialties > Dermatology > Diseases of Pigmentation
Congenital Patterned Leukodermas: Treatment & Medication
Updated: Nov 6, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
Treatment
Medical Care
- Limited medical treatment is available for abnormalities of the skin, hair, eyes, or ears that result from a paucity or absence of melanocytes. Surgical skin-grafting techniques have been developed, with variable success in establishing pigmentation. Camouflaging involved areas with skin stains or sunless self-tanning agents may be helpful to some patients. The use of sunscreens and clothing is recommended to protect against ultraviolet light–induced skin damage.
- Surgery may be necessary to correct extensive craniofacial defects in patients with Waardenburg or Apert syndromes.
- Colostomy may be necessary in patients with Hirschsprung syndrome and aganglionic megacolon.
More on Congenital Patterned Leukodermas |
| Overview: Congenital Patterned Leukodermas |
| Differential Diagnoses & Workup: Congenital Patterned Leukodermas |
Treatment & Medication: Congenital Patterned Leukodermas |
| Follow-up: Congenital Patterned Leukodermas |
| References |
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References
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Mollet I, Ongenae K, Naeyaert JM. Origin, clinical presentation, and diagnosis of hypomelanotic skin disorders. Dermatol Clin. Jul 2007;25(3):363-71, ix. [Medline].
Puffenberger EG, Kauffman ER, Bolk S, et al. Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. Hum Mol Genet. Aug 1994;3(8):1217-25. [Medline].
Read AP, Newton VE. Waardenburg syndrome. J Med Genet. Aug 1997;34(8):656-65. [Medline].
Tomita Y, Suzuki T. Genetics of pigmentary disorders. Am J Med Genet C Semin Med Genet. Nov 15 2004;131C(1):75-81. [Medline].
Further Reading
Keywords
congenital patterned leukodermas, congenital patterned leukoderma, Waardenburg syndrome, Apert syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Crouzon syndrome, Hirschsprung syndrome, piebaldism, congenital hypopigmentary diseases, pigment cells, melanocytes, embryogenesis, gene, band 2q35-q37.3, microphthalmia transcription factor gene, gene, band 3p12, fibroblast growth factor receptor-2 gene, gene, band 10q25-q26, fibroblast growth factor receptor-1 gene, gene, band 8p11.2-12, endothelin-B receptor gene, gene, band 13q22, gene, band 4q12
Treatment & Medication: Congenital Patterned Leukodermas