eMedicine Specialties > Dermatology > Diseases of Pigmentation

Pityriasis Alba

Author: Bassam Zeina, MD, PhD, Consulting Staff, Department of Dermatology, Milton Keynes Hospital, UK
Coauthor(s): Nicole Sakka, MBBS, Senior House Officer, Department of Dermatology, Milton Keynes Hospital, NHS Foundation Trust, UK; Sohail Mansoor, MBBS, MSc, Dermatologist and Lead Physician in Dermatologic Surgery, Department of Dermatology, Barnet Hospital, UK
Contributor Information and Disclosures

Updated: Sep 2, 2009

Introduction

Background

Pityriasis alba is a nonspecific dermatitis of unknown etiology that causes erythematous scaly patches. These resolve and leave areas of hypopigmentation that slowly repigment to normal. Pityriasis alba commonly occurs in children.

Pathophysiology

Pityriasis alba has been regarded as a manifestation of atopic dermatitis.1,2 Pityriasis alba is known to occur in nonatopic individuals. Pityriacitrin, a substance produced by Malassezia yeasts, acts as a natural sunscreen, but much of the hypopigmentation results from a failure of melanin transfer from melanocytes to keratinocytes.3

Frequency

The frequency of pityriasis alba both in the United States and internationally is unknown.

International

A large study in a tropical region in schoolchildren showed that the prevalence of pityriasis alba was 9.9%. Another study in Nepal showed that the prevalence of pityriasis alba within a wide range of dermatoses was 5.2%.4

Mortality/Morbidity

Pityriasis alba is not associated with mortality. Pityriasis alba is usually a self-limited, asymptomatic disease.

Race

Pityriasis alba can affect persons of any race, but it may be more prominent and cosmetically more troublesome in dark-skinned patients.5

Sex

Both sexes are equally susceptible to pityriasis alba, but it is thought that males are affected more frequently.6

Age

Pityriasis alba occurs predominantly in children aged 3-16 years.5 but can occur in adults.7

Clinical

History

  • Lesions in pityriasis alba are commonly asymptomatic, although some patients report mild pruritus or a burning sensation.
  • Erythema is usually mild and may initially be conspicuous. Minimal serous crusting may even occur at a few points on the surface of some of the pityriasis alba plaques.
  • Erythema later subsides completely to leave areas of hypopigmentation with or without fine scaling.
  • At the stage when a physician commonly observes pityriasis alba lesions, they show only persistent fine scaling and depigmentation. This commonly induces the patient to seek advice.
  • Pityriasis alba may be conspicuous in heavily pigmented skin. In lighter skins, pityriasis alba may become conspicuous after sun tanning. Pityriasis alba is considered a skin disorder of late summer because reports  describe that excessive and unprotected sun exposure are strongly related in the development of pityriasis alba.6
  • Pityriasis alba is associated with atopic diathesis. Inquire about a patient and family history of eczema, asthma, and/or hayfever.7
  • The course of pityriasis alba is extremely variable. Most cases persist for several months, and some still show leukoderma for a year or more after all scaling subsides.
  • Recurrent crops of new lesions may develop at intervals.
  • The average duration of the common facial form in childhood is a year or more.
  • Widespread cases overlap with a condition termed progressive and extensive hypomelanosis.8 Progressive and extensive hypomelanosis occurs mainly in women from 18-25 years, with progressive development of round, pale coalescent macules mainly on the back that are unresponsive to therapy but spontaneously regress within 3-4 years.9

Physical

  • The individual pityriasis alba lesion is a rounded, oval, or irregular plaque that is red, pink, or skin colored and has fine lamellar or branny scaling with indistinct margins.
  • Several patches are usually observed.
  • In children, pityriasis alba lesions are often confined to the face and are most common around the mouth, chin, and cheeks (see Media File 1). Legs and trunk are less commonly involved.


Pityriasis alba.

Pityriasis alba.

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Pityriasis alba.

Pityriasis alba.

  • In 20% of affected children, the neck, arms, and face are involved.
  • Less commonly, the face is spared and scattered pityriasis alba lesions are observed on the trunk and limbs.
  • Pityriasis alba lesions usually range from 0.5-2 cm in diameter but may be larger, especially on the trunk.
  • Two uncommon variants exist, a pigmenting variety and an extensive type. In pigmenting pityriasis alba, the typical lesion is a central zone of bluish hyperpigmentation surrounded by a hypopigmented, slightly scaly halo of variable width, usually confined to the face and often associated with dermatophyte infection.10 Extensive pityriasis alba is differentiated from the classic form by the widespread and symmetrical involvement of the skin, no preceding inflammatory phase, a higher female-to-male ratio, and, histologically, the absence of spongiosis.11

Causes

  • The cause is unknown. The condition has been regarded as a manifestation of atopic dermatitis or other mild forms of eczema.
  • Reported contributory factors related to the development of pityriasis alba are excessive and unprotected sun exposure, poor hygienic habits, and environmental influences such as temperature, humidity, and altitude.6

More on Pityriasis Alba

Overview: Pityriasis Alba
Differential Diagnoses & Workup: Pityriasis Alba
Treatment & Medication: Pityriasis Alba
Follow-up: Pityriasis Alba
Multimedia: Pityriasis Alba
References
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References

  1. Sandhu K, Handa S, Kanwar AJ. Extensive pityriasis alba in a child with atopic dermatitis. Pediatr Dermatol. May-Jun 2004;21(3):275-6. [Medline].

  2. Watkins DB. Pityriasis alba: a form of atopic dermatitis. A preliminary report. Arch Dermatol. Jun 1961;83:915-9. [Medline].

  3. Gambichler T, Kramer HJ, Boms S, et al. Quantification of ultraviolet protective effects of pityriacitrin in humans. Arch Dermatol Res. Dec 2007;299(10):517-20. [Medline].

  4. Walker SL, Shah M, Hubbard VG, Pradhan HM, Ghimire M. Skin disease is common in rural Nepal: results of a point prevalence study. Br J Dermatol. Feb 2008;158(2):334-8. [Medline].

  5. Martin RF, Lugo-Somolinos A, Sanchez JL. Clinicopathologic study on pityriasis alba. Bol Asoc Med P R. Oct 1990;82(10):463-5. [Medline].

  6. Blessmann Weber M, Sponchiado de Avila LG, Albaneze R, Magalhaes de Oliveira OL, Sudhaus BD, Cestari TF. Pityriasis alba: a study of pathogenic factors. J Eur Acad Dermatol Venereol. Sep 2002;16(5):463-8. [Medline].

  7. Rigopoulos D, Gregoriou S, Charissi C, Kontochristopoulos G, Kalogeromitros D, Georgala S. Tacrolimus ointment 0.1% in pityriasis alba: an open-label, randomized, placebo-controlled study. Br J Dermatol. Jul 2006;155(1):152-5. [Medline].

  8. Di Lernia V, Ricci C. Progressive and extensive hypomelanosis and extensive pityriasis alba: same disease, different names?. J Eur Acad Dermatol Venereol. May 2005;19(3):370-2. [Medline].

  9. Guillet G, Helenon R, Gauthier Y, Surleve-Bazeille JE, Plantin P, Sassolas B. Progressive macular hypomelanosis of the trunk: primary acquired hypopigmentation. J Cutan Pathol. Oct 1988;15(5):286-9. [Medline].

  10. du Toit MJ, Jordaan HF. Pigmenting pityriasis alba. Pediatr Dermatol. Mar 1993;10(1):1-5. [Medline].

  11. Di Lernia V, Ricci C. Progressive and extensive hypomelanosis and extensive pityriasis alba: same disease, different names?. J Eur Acad Dermatol Venereol. May 2005;19(3):370-2. [Medline].

  12. Whitmore SE, Simmons-O'Brien E, Rotter FS. Hypopigmented mycosis fungoides. Arch Dermatol. Apr 1994;130(4):476-80. [Medline].

  13. Vargas-Ocampo F. Pityriasis alba: a histologic study. Int J Dermatol. Dec 1993;32(12):870-3. [Medline].

  14. Zaynoun ST, Aftimos BG, Tenekjian KK, Bahuth N, Kurban AK. Extensive pityriasis alba: a histological histochemical and ultrastructural study. Br J Dermatol. Jan 1983;108(1):83-90. [Medline].

  15. Harper J. Topical corticosteroids for skin disorders in infants and children. Drugs. 1988;36 Suppl 5:34-7. [Medline].

  16. Bassaly M, Miale A Jr, Prasad AS. Studies on pityriasis alba. A common facial skin lesion in Egyptian children. Arch Dermatol. Sep 1963;88:272-5. [Medline].

  17. Dhar S, Kanwar AJ, Dawn G. Pigmenting pityriasis alba. Pediatr Dermatol. Jun 1995;12(2):197-8. [Medline].

  18. Fung WK, Lo KK. Prevalence of skin disease among school children and adolescents in a Student Health Service Center in Hong Kong. Pediatr Dermatol. Nov-Dec 2000;17(6):440-6. [Medline].

  19. Galan EB, Janniger CK. Pityriasis alba. Cutis. Jan 1998;61(1):11-3. [Medline].

  20. Hacker SM. Common disorders of pigmentation: when are more than cosmetic cover-ups required?. Postgrad Med. Jun 1996;99(6):177-86. [Medline].

  21. Lin RL, Janniger CK. Pityriasis alba. Cutis. Jul 2005;76(1):21-4. [Medline].

  22. Mevorah B, Frenk E, Wietlisbach V, Carrel CF. Minor clinical features of atopic dermatitis. Evaluation of their diagnostic significance. Dermatologica. 1988;177(6):360-4. [Medline].

  23. O'Farreli N. Pityriasis alba. Arch Dermatol. 1956;73:376-7.

  24. Wells BT, Whyte HJ, Kierland RR. Pityriasis alba: a ten-year survey and review of the literature. Arch Dermatol. Aug 1960;82:183-9. [Medline].

  25. Wolf R, Wolf D, Trau H. Pityriasis alba in a psoriatic location. Acta Derm Venereol. Sep 1992;72(5):360. [Medline].

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Further Reading

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Keywords

pityriasis alba, hypopigmentation, erythematous scaly patches, atopic dermatitis

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Contributor Information and Disclosures

Author

Bassam Zeina, MD, PhD, Consulting Staff, Department of Dermatology, Milton Keynes Hospital, UK
Bassam Zeina, MD, PhD is a member of the following medical societies: British Association of Dermatologists, British Medical Association, and Royal Society of Medicine
Disclosure: Nothing to disclose.

Coauthor(s)

Nicole Sakka, MBBS, Senior House Officer, Department of Dermatology, Milton Keynes Hospital, NHS Foundation Trust, UK
Disclosure: Nothing to disclose.

Sohail Mansoor, MBBS, MSc, Dermatologist and Lead Physician in Dermatologic Surgery, Department of Dermatology, Barnet Hospital, UK
Sohail Mansoor, MBBS, MSc is a member of the following medical societies: American Academy of Anti-Aging Medicine, American Academy of Dermatology, American Society for Dermatologic Surgery, Royal College of Physicians and Surgeons of Glasgow, and Royal College of Physicians of the United Kingdom
Disclosure: Nothing to disclose.

Medical Editor

Mark G Lebwohl, MD, Chairman, Department of Dermatology, Mount Sinai School of Medicine
Mark G Lebwohl, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Abbott Laboratories Honoraria Consulting; Actelion Honoraria Consulting; Amgen Honoraria Consulting; Astellas Honoraria Consulting; Centocor Honoraria Consulting; DermiPsor Honoraria Consulting; Galderma  Consulting; Genentech Honoraria Consulting; Helix BioMedix Honoraria Consulting; Medicis Honoraria Investigator

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Managing Editor

Christen M Mowad, MD, Associate Professor, Department of Dermatology, Geisinger Medical Center
Christen M Mowad, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa
Disclosure: Nothing to disclose.

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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