eMedicine Specialties > Dermatology > Diseases of the Adnexa
Alopecia Areata: Follow-up
Updated: Apr 13, 2009
Follow-up
Deterrence/Prevention
- Alopecia areata is highly unpredictable. No treatment is effective in preventing or halting progression of the condition. No trigger can be found to explain disease exacerbation in most patients.
Prognosis
- The natural history of alopecia areata is unpredictable. Most patients have only a few focal areas of alopecia, and spontaneous regrowth usually occurs within 1 year.
- Estimates indicate less than 10% of patients experience extensive alopecia and less than 1% have alopecia universalis.
- Patients with extensive longstanding conditions are less likely to experience significant long-lasting regrowth.
- Adverse prognostic factors include nail abnormalities, atopy, onset at a young age, and severe forms of alopecia areata.
Patient Education
- Patient education is a key factor in alopecia areata. Inform patients of the chronic relapsing nature of alopecia areata. Reassure patients that the condition is benign and does not threaten their general health.
- Most patients try to find an explanation about why this is happening to them. Reassure these patients that they have done nothing wrong and that it is not their fault.
- Inform patients that expectations regarding therapy should be realistic.
- Support groups are available in many cities; it is strongly recommended that patients be urged to contact the National Alopecia Areata Foundation at 710 C St, Suite 11, San Rafael, CA94901 or view the Web site.
- Many patients are reluctant to use hairpieces or take part in support groups because, at first, these often are perceived as last-resort options. Take the time to discuss the options with patients because they are of great benefit.
Miscellaneous
Medicolegal Pitfalls
- Failure to discuss at length realistic treatment expectations and treatments that have serious adverse effects or are not approved by the Food and Drug Administration (ie, topical immunotherapy)
- Medscape Medical Malpractice and Legal Issues Resource Center
More on Alopecia Areata |
| Overview: Alopecia Areata |
| Differential Diagnoses & Workup: Alopecia Areata |
| Treatment & Medication: Alopecia Areata |
Follow-up: Alopecia Areata |
| Multimedia: Alopecia Areata |
| References |
| « Previous Page | Next Page » |
References
McElwee KJ, Tobin DJ, Bystryn JC, King LE Jr, Sundberg JP. Alopecia areata: an autoimmune disease?. Exp Dermatol. Oct 1999;8(5):371-9. [Medline].
van der Steen P, Traupe H, Happle R, Boezeman J, Sträter R, Hamm H. The genetic risk for alopecia areata in first degree relatives of severely affected patients. An estimate. Acta Derm Venereol. Sep 1992;72(5):373-5. [Medline].
Colombe BW, Lou CD, Price VH. The genetic basis of alopecia areata: HLA associations with patchy alopecia areata versus alopecia totalis and alopecia universalis. J Investig Dermatol Symp Proc. Dec 1999;4(3):216-9. [Medline].
Colombe BW, Price VH, Khoury EL, Garovoy MR, Lou CD. HLA class II antigen associations help to define two types of alopecia areata. J Am Acad Dermatol. Nov 1995;33(5 Pt 1):757-64. [Medline].
Price VH, Colombe BW. Heritable factors distinguish two types of alopecia areata. Dermatol Clin. Oct 1996;14(4):679-89. [Medline].
Jackow C, Puffer N, Hordinsky M, Nelson J, Tarrand J, Duvic M. Alopecia areata and cytomegalovirus infection in twins: genes versus environment?. J Am Acad Dermatol. Mar 1998;38(3):418-25. [Medline].
Safavi K. Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey. Arch Dermatol. May 1992;128(5):702. [Medline].
Safavi KH, Muller SA, Suman VJ, Moshell AN, Melton LJ 3rd. Incidence of alopecia areata in Olmsted County, Minnesota, 1975 through 1989. Mayo Clin Proc. Jul 1995;70(7):628-33. [Medline].
Muller SA, Winkelmann RK. Alopecia areata. An evaluation of 736 patients. Arch Dermatol. Sep 1963;88:290-7. [Medline].
Sharma VK, Dawn G, Kumar B. Profile of alopecia areata in Northern India. Int J Dermatol. Jan 1996;35(1):22-7. [Medline].
Puavilai S, Puavilai G, Charuwichitratana S, Sakuntabhai A, Sriprachya-Anunt S. Prevalence of thyroid diseases in patients with alopecia areata. Int J Dermatol. Sep 1994;33(9):632-3. [Medline].
Werth VP, White WL, Sanchez MR, Franks AG. Incidence of alopecia areata in lupus erythematosus. Arch Dermatol. Mar 1992;128(3):368-71. [Medline].
Wang SJ, Shohat T, Vadheim C, Shellow W, Edwards J, Rotter JI. Increased risk for type I (insulin-dependent) diabetes in relatives of patients with alopecia areata (AA). Am J Med Genet. Jul 1 1994;51(3):234-9. [Medline].
Perini GI, Veller Fornasa C, Cipriani R, Bettin A, Zecchino F, Peserico A. Life events and alopecia areata. Psychother Psychosom. 1984;41(1):48-52. [Medline].
Tosti A, De Padova MP, Minghetti G, Veronesi S. Therapies versus placebo in the treatment of patchy alopecia areata. J Am Acad Dermatol. Aug 1986;15(2 Pt 1):209-10. [Medline].
Vestey JP, Savin JA. Natural history of severe alopecia areata. Br J Dermatol. Oct 1987;117(4):531. [Medline].
Tosti A, Piraccini BM, Pazzaglia M, Vincenzi C. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis/universalis. J Am Acad Dermatol. Jul 2003;49(1):96-8. [Medline].
Hoffmann R, Happle R. Topical immunotherapy in alopecia areata. What, how, and why?. Dermatol Clin. Oct 1996;14(4):739-44. [Medline].
Rokhsar CK, Shupack JL, Vafai JJ, Washenik K. Efficacy of topical sensitizers in the treatment of alopecia areata. J Am Acad Dermatol. Nov 1998;39(5 Pt 1):751-61. [Medline].
Wiseman MC, Shapiro J, MacDonald N, Lui H. Predictive model for immunotherapy of alopecia areata with diphencyprone. Arch Dermatol. Aug 2001;137(8):1063-8. [Medline].
Tang L, Cao L, Sundberg JP, Lui H, Shapiro J. Restoration of hair growth in mice with an alopecia areata-like disease using topical anthralin. Exp Dermatol. Jan 2004;13(1):5-10. [Medline].
Taylor CR, Hawk JL. PUVA treatment of alopecia areata partialis, totalis and universalis: audit of 10 years' experience at St John's Institute of Dermatology. Br J Dermatol. Dec 1995;133(6):914-8. [Medline].
Sharma VK. Pulsed administration of corticosteroids in the treatment of alopecia areata. Int J Dermatol. Feb 1996;35(2):133-6. [Medline].
Price VH, Willey A, Chen BK. Topical tacrolimus in alopecia areata. J Am Acad Dermatol. Jan 2005;52(1):138-9. [Medline].
Joly P. The use of methotrexate alone or in combination with low doses of oral corticosteroids in the treatment of alopecia totalis or universalis. J Am Acad Dermatol. Oct 2006;55(4):632-6. [Medline].
Ross EK, Bolduc C, Lui H, Shapiro J. Lack of efficacy of topical latanoprost in the treatment of eyebrow alopecia areata. J Am Acad Dermatol. Dec 2005;53(6):1095-6. [Medline].
Price VH. Treatment of hair loss. N Engl J Med. Sep 23 1999;341(13):964-73. [Medline].
Strober BE, Siu K, Alexis AF, Kim G, Washenik K, Sinha A, et al. Etanercept does not effectively treat moderate to severe alopecia areata: an open-label study. J Am Acad Dermatol. Jun 2005;52(6):1082-4. [Medline].
Fiedler VC. Alopecia areata. A review of therapy, efficacy, safety, and mechanism. Arch Dermatol. Nov 1992;128(11):1519-29. [Medline].
Fiedler VC, Alaiti S. Treatment of alopecia areata. Dermatol Clin. Oct 1996;14(4):733-7. [Medline].
MacDonald Hull SP, Wood ML, Hutchinson PE, Sladden M, Messenger AG. Guidelines for the management of alopecia areata. Br J Dermatol. Oct 2003;149(4):692-9. [Medline].
MacDonald N. Alopecia areata: identification and current treatment approaches. Dermatol Nurs. Oct 1999;11(5):356-9, 363-6. [Medline].
Madani S, Shapiro J. Alopecia areata update. J Am Acad Dermatol. Apr 2000;42(4):549-66; quiz 567-70. [Medline].
McDonagh AJ, Messenger AG. The pathogenesis of alopecia areata. Dermatol Clin. Oct 1996;14(4):661-70. [Medline].
Shapiro J, Price VH. Hair regrowth. Therapeutic agents. Dermatol Clin. Apr 1998;16(2):341-56. [Medline].
Shellow WV, Edwards JE, Koo JY. Profile of alopecia areata: a questionnaire analysis of patient and family. Int J Dermatol. Mar 1992;31(3):186-9. [Medline].
Whiting D. Dermatopathology of common hair problems. J Cutan Med Surg. Nov 1999;3 Suppl 3:S3-13. [Medline].
Further Reading
Keywords
alopecia areata, hair loss, autoimmune alopecia, baldness
Follow-up: Alopecia Areata