Neutrophilic Eccrine Hidradenitis Follow-up

  • Author: Joseph C Pierson, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jul 18, 2011
 

Further Outpatient Care

Neutrophilic eccrine hidradenitis (NEH) is typically a self-limited eruption. Continue symptomatic care as needed.

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Prognosis

Many patients experience recurrent symptoms with subsequent courses of chemotherapy. One patient avoided painful recurrences with prophylactic dapsone. Possible hematologic toxicity with dapsone in the setting of chemotherapy regimens is a concern.[23]

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Contributor Information and Disclosures
Author

Joseph C Pierson, MD  Consulting Staff, Department of Dermatology, Guthrie Army Clinic, Ft Drum, NY

Joseph C Pierson, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

Christine C Tam, MD  Staff Physician, Dermatology Office of David A Spott, MD

Christine C Tam, MD is a member of the following medical societies: American Medical Association

Disclosure: Nothing to disclose.

Specialty Editor Board

Robert A Schwartz, MD, MPH  Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi

Disclosure: Nothing to disclose.

Michael J Wells, MD  Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine

Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association

Disclosure: Nothing to disclose.

Warren R Heymann, MD  Head, Division of Dermatology, Professor, Department of Internal Medicine, University of Medicine and Dentistry of New Jersey-New Jersey Medical School

Warren R Heymann, MD is a member of the following medical societies: American Academy of Dermatology, American Society of Dermatopathology, and Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Joel M Gelfand, MD, MSCE  Medical Director, Clinical Studies Unit, Assistant Professor, Department of Dermatology, Associate Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania

Joel M Gelfand, MD, MSCE is a member of the following medical societies: Society for Investigative Dermatology

Disclosure: AMGEN Consulting fee Consulting; AMGEN Grant/research funds Investigator; Genentech Grant/research funds investigator; Centocor Consulting fee Consulting; Abbott Grant/research funds investigator; Abbott Consulting fee Consulting; Novartis investigator; Pfizer Grant/research funds investigator; Celgene Consulting fee DMC Chair; NIAMS and NHLBI Grant/research funds investigator

Chief Editor

Dirk M Elston, MD  Director, Ackerman Academy of Dermatopathology, New York

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References

  1. Harrist TJ, Fine JD, Berman RS, Murphy GF, Mihm MC Jr. Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy. Arch Dermatol. Apr 1982;118(4):263-6. [Medline].

  2. Bolognia JL, Cooper DL, Glusac EJ. Toxic erythema of chemotherapy: a useful clinical term. J Am Acad Dermatol. Sep 2008;59(3):524-9. [Medline].

  3. Cohen PR. Neutrophilic dermatoses occurring in oncology patients. Int J Dermatol. Jan 2007;46(1):106-11. [Medline].

  4. Pierson JC, Helm TN, Taylor JS, Elston DM, Tuthill RJ. Neutrophilic eccrine hidradenitis heralding the onset of acute myelogenous leukemia. Arch Dermatol. Jun 1993;129(6):791-2. [Medline].

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  8. Morice A, Penven K, Comoz F, Cribier B, Dompmartin A, Leroy D. [Neutrophilic eccrine hidradenitis in a healthy patient]. Ann Dermatol Venereol. Aug-Sep 2005;132(8-9 Pt 1):686-8. [Medline].

  9. EL Sayed F, Ammoury A, Chababi M, Dhaybi R, Bazex J. Neutrophilic eccrine hidradenitis to acetaminophen. J Eur Acad Dermatol Venereol. Nov 2006;20(10):1338-40. [Medline].

  10. Lienesch DW, Mutasim DF, Singh RR. Neutrophilic eccrine hidradenitis mimicking cutaneous vasculitis in a lupus patient: a complication of cyclophosphamide. Lupus. 2003;12(9):707-9. [Medline].

  11. Tojo M, Iwatsuki K, Furukawa H, Takahashi M, Kaneko F. Neutrophilic eccrine hidradenitis in actinic reticuloid syndrome. Eur J Dermatol. Mar-Apr 2002;12(2):198-200. [Medline].

  12. Bilic M, Mutasim DF. Neutrophilic eccrine hidradenitis in a patient with Behçet's disease. Cutis. Aug 2001;68(2):107-11. [Medline].

  13. Shih IH, Huang YH, Yang CH, Yang LC, Hong HS. Childhood neutrophilic eccrine hidradenitis: a clinicopathologic and immunohistochemical study of 10 patients. J Am Acad Dermatol. Jun 2005;52(6):963-6. [Medline].

  14. Bachmeyer C, Aractingi S. Neutrophilic eccrine hidradenitis. Clin Dermatol. May-Jun 2000;18(3):319-30. [Medline].

  15. Headley CM, Ioffreda MD, Zaenglein AL. Neutrophilic eccrine hidradenitis: a case report of an unusual annular presentation. Cutis. Feb 2005;75(2):93-7. [Medline].

  16. Yasukawa K, Kato N, Aikawa K, Kodama K, Hamasaka A, Hata H. Neutrophilic eccrine hidradenitis with sclerodermoid change heralding the relapse of acute myelogenous leukemia: is this a paraneoplastic phenomenon?. Dermatology. 2007;215(3):261-4. [Medline].

  17. Bardenstein DS, Haluschak J, Gerson S, Zaim MT. Neutrophilic eccrine hidradenitis simulating orbital cellulitis. Arch Ophthalmol. Nov 1994;112(11):1460-3. [Medline].

  18. Srivastava M, Scharf S, Meehan SA, Polsky D. Neutrophilic eccrine hidradenitis masquerading as facial cellulitis. J Am Acad Dermatol. Apr 2007;56(4):693-6. [Medline].

  19. Ostlere LS, Wells J, Stevens HP, Prentice G, Rustin MH. Neutrophilic eccrine hidradenitis with an unusual presentation. Br J Dermatol. Jun 1993;128(6):696-8. [Medline].

  20. Lee WJ, Kim CH, Chang SE, Lee MW, Choi JH, Moon KC, et al. Generalized idiopathic neutrophilic eccrine hidradenitis in childhood. Int J Dermatol. Jan 2010;49(1):75-8. [Medline].

  21. Templeton SF, Solomon AR, Swerlick RA. Intradermal bleomycin injections into normal human skin. A histopathologic and immunopathologic study. Arch Dermatol. May 1994;130(5):577-83. [Medline].

  22. Belot V, Perrinaud A, Corven C, de Muret A, Lorette G, Machet L. [Adult idiopathic neutrophilic eccrine hidradenitis treated with colchicine]. Presse Med. Oct 2006;35(10 Pt 1):1475-8. [Medline].

  23. Shear NH, Knowles SR, Shapiro L, Poldre P. Dapsone in prevention of recurrent neutrophilic eccrine hidradenitis. J Am Acad Dermatol. Nov 1996;35(5 Pt 2):819-22. [Medline].

  24. Antonovich DD, Berke A, Grant-Kels JM, Fung M. Infectious eccrine hidradenitis caused by Nocardia. J Am Acad Dermatol. Feb 2004;50(2):315-8. [Medline].

  25. Bernstein EF, Spielvogel RL, Topolsky DL. Recurrent neutrophilic eccrine hidradenitis. Br J Dermatol. Nov 1992;127(5):529-33. [Medline].

  26. Laffitte E, Hohl D, Panizzon RG. [Pseudomonas eccrine hidradenitis in a child revealing acute lymphoblastic leukemia]. Ann Dermatol Venereol. Nov 2004;131(11):975-8. [Medline].

  27. Takai T, Matsunaga A. A case of neutrophilic eccrine hidradenitis associated with streptococcal infectious endocarditis. Dermatology. 2006;212(2):203-5. [Medline].

 
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Courtesy of Jeffrey P. Callen, MD.
Neutrophilic infiltrate on hematoxylin and eosin stain (100X). Courtesy of Jeffrey P. Callen, MD, and Vilma Fabre, MD.
 
 
 
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