Anti-inflammatory systemic and/or topical therapy similar to that used for rosacea is required. Photodynamic therapy (PDT) has been reported to be helpful for perioral dermatitis (POD),  although large studies have not yet been performed.
Topical praziquantel effectively improved symptoms of perioral dermatitis and quality of life in a small vehicle-controlled study. 
Treatment should be adapted to the severity and extension of the disease.
Reassurance and education about possible underlying factors and the time course of the disease are critical. These measures help the patient to cope with the disfiguring character of the disease and help to minimize the risk of recurrences.
The use of cosmetics, cleansers, and moisturizers should be avoided during treatment.
In 2014, a treatment algorithm was proposed to assist physicians in finding the appropriate therapy. 
Consult a dermatologist to evaluate provoking factors and to determine the individualized treatment.
In general, physical activity is not restricted; however, vasodilation of dermal vessels due to strenuous physical exercise may worsen subjective symptoms.
If provoking factors can be determined, they should be avoided.
Care includes an assessment of the effectiveness of systemic therapy. Topical therapy should be adapted in accordance to the condition of the skin and the severity of the disease.
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