Laboratory Studies
The diagnosis of trichostasis spinulosa (TS) can be made clinically without obtaining a biopsy specimen. If the diagnosis is in doubt, a specimen may easily be obtained by removing a hair plug with a forceps or comedone extractor. The specimen should be placed on a glass slide and covered for examination.
Histologic Findings
Treatment with potassium hydroxide dissolves the keratinous plug, leaving numerous vellus hairs in a characteristic tuft. If a biopsy specimen is obtained, microscopic examination reveals a dilated hair follicle with hyperkeratosis and acanthosis of the follicular epithelium (see the images below). Inflammatory changes are not a characteristic of trichostasis spinulosa.
Biopsy specimen demonstrates a dilated follicle that contains numerous vellus hairs and keratin debris.
Potassium hydroxide mount of an extracted plug reveals multiple vellus hairs embedded in keratinous material. Sidwell RU, Francis N, Bunker CB. Diffuse trichostasis spinulosa in chronic renal failure. Clin Exp Dermatol. Jan 2006;31(1):86-8. [Medline].
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