Acne Fulminans Workup

Updated: Jun 06, 2016
  • Author: Ryszard Zaba, MD, PhD; Chief Editor: William D James, MD  more...
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Workup

Laboratory Studies

Findings in patients with acne fulminans include the following:

  • Leukocytosis (characteristic finding)
  • Increased percentage of polymorphonuclear leukocytes
  • Anemia
  • Leukemic-type reaction
  • Elevated erythrocyte sedimentation rate
  • Circulating immune complexes
  • Proteinuria
  • Sterile blood culture results
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Imaging Studies

Bone involvement is common. Approximately 50% of patients have lytic bone lesions demonstrated on radiographs, and 70% of patients show increased uptake using technetium scintillography ("hot spots"). Destructive lesions resembling osteomyelitis are demonstrated on radiographs in 25% of patients. Multifocal osteolytic cysts may be evident as tender bones and can be detected as hot spots by technetium scintillography.

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Histologic Findings

Analysis of biopsy specimens of the bony lesions shows reactive changes only.

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