Findings in patients with acne fulminans include the following:
Leukocytosis (characteristic finding)
Increased percentage of polymorphonuclear leukocytes
Elevated erythrocyte sedimentation rate
Circulating immune complexes
Sterile blood culture results
Bone involvement is common. Approximately 50% of patients have lytic bone lesions demonstrated on radiographs, and 70% of patients show increased uptake using technetium scintillography ("hot spots"). Destructive lesions resembling osteomyelitis are demonstrated on radiographs in 25% of patients. Multifocal osteolytic cysts may be evident as tender bones and can be detected as hot spots by technetium scintillography.
Analysis of biopsy specimens of the bony lesions shows reactive changes only.
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