Pseudoxanthoma Elasticum Medication

  • Author: L Frank Glass, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jun 23, 2011
 

Medication Summary

The goals of pharmacotherapy for pseudoxanthoma elasticum (PXE) are to reduce morbidity and to prevent complications, although lifestyle modification remains the mainstay of treatment.

In a randomized, placebo-controlled trial of sevelamer hydrochloride, a phosphate binder, for the treatment of PXE, calcification and clinical severity scores improved but were not superior to placebo. The presence of magnesium in the placebo may have clouded the results by causing a therapeutic benefit.[34]

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Hemorheologic agents

Class Summary

These agents are used for the symptomatic treatment of peripheral vascular disease.

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Pentoxifylline (Trental)

 

Alters erythrocyte rheology, which, in turn, reduces blood viscosity. May be used but with extreme caution of hemorrhage.

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Contributor Information and Disclosures
Author

L Frank Glass, MD  Chief of Dermatopathology, Associate Professor, Departments of Internal Medicine and Pathology, University of South Florida College of Medicine

L Frank Glass, MD is a member of the following medical societies: American Academy of Dermatology and American Society of Dermatopathology

Disclosure: Nothing to disclose.

Coauthor(s)

Neil Alan Fenske, MD  Chairman, Department of Dermatology and Cutaneous Surgery, Professor, Department of Dermatology and Cutaneous Surgery, Department of Pathology and Cell Biology, Department of Oncologic Sciences, University of South Florida College of Medicine

Disclosure: Dermik Honoraria Speaking and teaching; Amgen Honoraria Speaking and teaching; Graceway Pharmaceuticals Honoraria Speaking and teaching; Abbott Honoraria Speaking and teaching

Naomi G Johansen, MD  Resident Physician, Department of Dermatology and Cutaneous Surgery, University of South Florida College of Medicine

Disclosure: Nothing to disclose.

Specialty Editor Board

Mark G Lebwohl, MD  Chairman, Department of Dermatology, Mount Sinai School of Medicine

Mark G Lebwohl, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Amgen/Pfizer Honoraria Consulting; Centocor/Janssen Honoraria Consulting; DermiPsor Honoraria Consulting; GlaxoSmithKline Honoraria Consulting; HelixBioMedix Honoraria Consulting; Novartis Honoraria Consulting; Ranbaxy Lectures; Can-Fite Biopharma Honoraria Consulting; DermaGenoma Honoraria Consulting; Biosynexus Honoraria Consulting

Richard P Vinson, MD  Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Christen M Mowad, MD  Associate Professor, Department of Dermatology, Geisinger Medical Center

Christen M Mowad, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Department of Dermatology, Geisinger Medical Center

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Acknowledgments

The authors and editors of eMedicine gratefully acknowledge the contributions of previous Chief Editor, William D. James, MD, to the development and writing of this article.

References

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Classic cobblestone appearance with yellow papules and plaques on the lateral aspect of the neck.
Laxity and redundant skin folds in the axilla.
Flesh-colored reticulated plaques on the posterior neck.
Calcification and clumping of elastic fibers in pseudoxanthoma elasticum.
Aggregates of irregular calcified elastic fibers in the dermis.
Basophilic clusters in the mid and deep reticular dermis representing calcium deposition within elastic fibers in PXE.
 
 
 
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