eMedicine Specialties > Dermatology > Diseases of the Oral Mucosa

Nicotine Stomatitis: Differential Diagnoses & Workup

Author: Dana Gelman Keiles, DMD, Assistant Clinical Professor, Department of Stomatology, University of California at San Francisco
Coauthor(s): Sol Silverman, DDS, Professor, Department of Stomatology, University of California at San Francisco School of Dentistry
Contributor Information and Disclosures

Updated: Jun 26, 2009

Differential Diagnoses

Cancers of the Oral Mucosa
Candidiasis, Mucosal

Workup

Procedures

If unable to make the diagnosis by clinical appearance or if the lesion does not resolve after cessation of smoking, perform a 5-mm punch biopsy. A biopsy is also indicated in a patient with a symptomatic lesion or if the patient reports that he or she is a reverse smoker.

Histologic Findings

Histologically, these lesions appear acanthotic and hyperkeratotic, with some mild-to-moderate chronic inflammation. The epithelium of the minor salivary ducts often shows squamous metaplasia.

More on Nicotine Stomatitis

Overview: Nicotine Stomatitis
Differential Diagnoses & Workup: Nicotine Stomatitis
Treatment & Medication: Nicotine Stomatitis
Follow-up: Nicotine Stomatitis
Multimedia: Nicotine Stomatitis
References
Further Reading

References

  1. Thoma KH. Stomatitis nicotine and its effect on the palate. Am J Orthod. 1941;27:38-47.

  2. Rossie KM, Guggenheimer J. Thermally induced 'nicotine' stomatitis. A case report. Oral Surg Oral Med Oral Pathol. Nov 1990;70(5):597-9. [Medline].

  3. Vellappally S, Fiala Z, Smejkalova J, Jacob V, Somanathan R. Smoking related systemic and oral diseases. Acta Medica (Hradec Kralove). 2007;50(3):161-6. [Medline].

  4. Mathew AL, Pai KM, Sholapurkar AA, Vengal M. The prevalence of oral mucosal lesions in patients visiting a dental school in Southern India. Indian J Dent Res. Apr-Jun 2008;19(2):99-103. [Medline].

  5. Pentenero M, Broccoletti R, Carbone M, Conrotto D, Gandolfo S. The prevalence of oral mucosal lesions in adults from the Turin area. Oral Dis. May 2008;14(4):356-66. [Medline].

  6. Lynch MA, Brightman VJ, Greenberg MS, eds. Keratotic white lesions with no increased potential for development of oral cancer. In: Burket's Oral Medicine. 9th ed. Toronto, Canada: Decker; 1994:73-82.

  7. Silverman S Jr, ed. Oral Cancer. 5th ed. Hamilton, Canada: BC Decker; 2003:1-16.

  8. [Best Evidence] Myung SK, McDonnell DD, Kazinets G, Seo HG, Moskowitz JM. Effects of Web- and computer-based smoking cessation programs: meta-analysis of randomized controlled trials. Arch Intern Med. May 25 2009;169(10):929-37. [Medline].

  9. [Guideline] United States Preventive Services Task Force. Screening for oral cancer: recommendation statement. National Guideline Clearinghouse. Feb 2004.

  10. [Guideline] HealthPartners Dental Group. Clinics guidelines for the diagnosis and treatment of periodontal diseases. National Guideline Clearinghouse. Mar 2006.

  11. Koski OR, Rhyne RR, Correll RW, Craig RM. Irregular papular lesions of the hard palate. J Am Dent Assoc. Aug 1980;101(2):293-4. [Medline].

  12. Mani NJ. Tobacco smoking and associated oral lesions. Ann Dent. Summer 1984;43(1):6-14. [Medline].

  13. Mirbod SM, Ahing SI. Tobacco-associated lesions of the oral cavity: Part I. Nonmalignant lesions. J Can Dent Assoc. May 2000;66(5):252-6. [Medline].

Further Reading

Clinical guidelines

Screening for oral cancer: recommendation statement. 9
United States Preventive Services Task Force - Independent Expert Panel.  1996 (revised 2004 Feb 24).  4 pages.  NGC:003454

HealthPartners Dental Group and Clinics guidelines for the diagnosis and treatment of periodontal diseases. 10
HealthPartners Dental Group - Professional Association.  2006 Mar.  85 pages.  NGC:005629

Clinical trials

Spectroscopy for Diagnostic Assessment of Oral Mucosal Lesions

Study of Epidermal Growth Factor on Oral Mucositis Induced by Intensive Chemotherapy for Hematologic Malignancies (EGFOM)

Related eMedicine topics

Cancers of the Oral Mucosa

Candidiasis, Mucosal

Premalignant Conditions of the Oral Cavity

Keywords

nicotinic stomatitis, smoker's palate, smoker's keratosis, smoker's patch

Contributor Information and Disclosures

Author

Dana Gelman Keiles, DMD, Assistant Clinical Professor, Department of Stomatology, University of California at San Francisco
Dana Gelman Keiles, DMD is a member of the following medical societies: American Academy of Oral Medicine and American Dental Association
Disclosure: Nothing to disclose.

Coauthor(s)

Sol Silverman, DDS, Professor, Department of Stomatology, University of California at San Francisco School of Dentistry
Sol Silverman, DDS is a member of the following medical societies: American Academy of Oral Medicine and American Dental Association
Disclosure: Nothing to disclose.

Medical Editor

Marjan Garmyn, MD, PhD, Professor, Faculty of Medicine, Katholieke Universiteit Leuven, Belgium; Chair and Adjunct Head, Department of Dermatology, University of Leuven, Belgium
Disclosure: Nothing to disclose.

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Managing Editor

Drore Eisen, MD, DDS, Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati
Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, and American Dental Association
Disclosure: Nothing to disclose.

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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