Epulis fissuratum is a mucosal hyperplasia that results from chronic low-grade trauma induced by a denture flange.  Epulis fissuratum is analogous to acanthoma fissuratum of skin.
Epulis fissuratum arises in association with denture flanges. Consequently, epulis fissuratum is usually observed in the maxillary or mandibular vestibule.
A study on the prevalence of oral lesions among 210 denture wearers found that oral lesions were found in 20.5% of the cases and that denture-induced fibrous hyperplasia was the most common type of lesion detected (41.9%). 
Significant morbidity does not occur with epulis fissuratum.
Most studies indicate a clear predilection for epulis fissuratum in females.  Possible atrophic epithelial changes secondary to menopause may influence an increased reaction to trauma in older females.
Epulis fissuratum occurs in greatest numbers in the fifth, sixth, and seventh decades, but it can be observed at almost any age. Epulis fissuratum has been described in children. The fact that the lesions are related to denture wear and chronicity of an irritative process explains the higher incidence in older individuals.