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Smoker's Melanosis Differential Diagnoses

  • Author: Leticia Ferreira, DDS, MS; Chief Editor: William D James, MD  more...
 
Updated: Jan 26, 2015
 
 
 
Contributor Information and Disclosures
Author

Leticia Ferreira, DDS, MS Assistant Professor of Pathology and Medicine, Department of Dental Practice, University of the Pacific, Arthur A Dugoni School of Dentistry

Leticia Ferreira, DDS, MS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, American Association of Women Dentists, American Dental Association, American Dental Education Association, California Dental Association, San Francisco Dental Society

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Drore Eisen, MD, DDS Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati

Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, American Dental Association

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

R Stan Taylor, MD The JB Howell Professor in Melanoma Education and Detection, Departments of Dermatology and Plastic Surgery, Director, Skin Surgery and Oncology Clinic, University of Texas Southwestern Medical Center

R Stan Taylor, MD is a member of the following medical societies: American Academy of Dermatology, American College of Mohs Surgery, American Medical Association

Disclosure: Nothing to disclose.

Acknowledgements

William M Carpenter, DDS, MS Professor, Chairman, Department of Pathology and Medicine, University of the Pacific, Arthur A Dugoni School of Dentistry

William M Carpenter, DDS, MS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology and American Academy of Oral Medicine

Disclosure: Nothing to disclose.

Dana Gelman Keiles, DMD Assistant Clinical Professor, Department of Stomatology, University of California at San Francisco

Dana Gelman Keiles, DMD is a member of the following medical societies: American Academy of Oral Medicine and American Dental Association

Disclosure: Nothing to disclose.

References
  1. Hedin CA. Smokers' melanosis. Occurrence and localization in the attached gingiva. Arch Dermatol. 1977 Nov. 113(11):1533-8. [Medline].

  2. Axéll T, Hedin CA. Epidemiologic study of excessive oral melanin pigmentation with special reference to the influence of tobacco habits. Scand J Dent Res. 1982 Dec. 90(6):434-42. [Medline].

  3. Hedin CA, Axéll T. Oral melanin pigmentation in 467 Thai and Malaysian people with special emphasis on smoker's melanosis. J Oral Pathol Med. 1991 Jan. 20(1):8-12. [Medline].

  4. Nwhator SO, Winfunke-Savage K, Ayanbadejo P, Jeboda SO. Smokers' melanosis in a Nigerian population: a preliminary study. J Contemp Dent. Pract. Jul 2007. 8(5):68-75. [Medline].

  5. Mehrotra R, Thomas S, Nair P, Pandya S, Singh M, Nigam NS, et al. Prevalence of oral soft tissue lesions in Vidisha. BMC Res Notes. 2010 Jan 25. 3:23. [Medline]. [Full Text].

  6. Sridharan G. Epidemiology, control and prevention of tobacco induced oral mucosal lesions in India. Indian J Cancer. 2014 Jan-Mar. 51(1):80-5. [Medline].

  7. Patil PB, Bathi R, Chaudhari S. Prevalence of oral mucosal lesions in dental patients with tobacco smoking, chewing, and mixed habits: A cross-sectional study in South India. J Family Community Med. 2013 May. 20(2):130-5. [Medline]. [Full Text].

  8. Ahmadi-Motamayel F, Falsafi P, Hayati Z, Rezaei F, Poorolajal J. Prevalence of oral mucosal lesions in male smokers and nonsmokers. Chonnam Med J. 2013 Aug. 49(2):65-8. [Medline]. [Full Text].

  9. Al-Attas SA, Ibrahim SS, Amer HA, Darwish Zel-S, Hassan MH. Prevalence of potentially malignant oral mucosal lesions among tobacco users in Jeddah, Saudi Arabia. Asian Pac J Cancer Prev. 2014. 15(2):757-62. [Medline].

  10. Marakoglu K, Gursoy, UK, Toker, HC, Demirer S, et al. Smoking status and smoke-related gingival melanin pigmentation in army recruitments. Mil Med. Jan 2007. 172:110-3. [Medline].

  11. Brown FH, Houston GD. Smoker's melanosis. A case report. J Periodontol. 1991 Aug. 62(8):524-7. [Medline].

  12. Hedin C, Pindborg JJ, Daftary DK, Mehta FS. Melanin depigmentation of the palatal mucosa in reverse smokers: a preliminary study. J Oral Pathol Med. 1992 Nov. 21(10):440-4. [Medline].

  13. Hedin CA, Pindborg JJ, Axéll T. Disappearance of smoker's melanosis after reducing smoking. J Oral Pathol Med. 1993 May. 22(5):228-30. [Medline].

  14. Zarate AM, Brezzo MM, Secchi DG, Barra JL, Brunotto M. Malignancy risk models for oral lesions. Med Oral Patol Oral Cir Bucal. 2013 Sep 1. 18(5):e759-65. [Medline]. [Full Text].

  15. [Guideline] US Preventive Services Task Force. Final Recommendation Statement: Tobacco Use in Adults and Pregnant Women: Counseling and Interventions. Available at http://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/tobacco-use-in-adults-and-pregnant-women-counseling-and-interventions. Accessed: January 26, 2015.

  16. Neville BW. Smoker's Melanosis. Neville BW, Damm DD, Allen CM, and Bouquot JE, eds. Oral & Maxillofacial Pathology. 3rd ed. Philadelphia, Pa: WB Saunders; 2002. 316-17.

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Several focal brownish pigmentations of the maxillary anterior gingiva.
Gingival biopsy of a basilar melanosis (a brownish granular pigment present along the basal cells).
A reverse smoker with white and pigmented palatal mucosa and a focal area of erythema.
 
 
 
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