Disorders of Oral Pigmentation: Multimedia

References

1. Boardman LA, Thibodeau SN, Schaid DJ, Lindor NM, McDonnell SK, Burgart LJ, et al. Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med. Jun 1 1998;128(11):896-9. [Medline].

2. Giardiello FM, Welsh SB, Hamilton SR, Offerhaus GJ, Gittelsohn AM, Booker SV, et al. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med. Jun 11 1987;316(24):1511-4. [Medline].

3. Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet. Jan 1998;18(1):38-43. [Medline].

4. Kirkwood JM, Resnick GD, Cole BF. Efficacy, safety, and risk-benefit analysis of adjuvant interferon alfa-2b in melanoma. Semin Oncol. Feb 1997;24(1 Suppl 4):S16-23. [Medline].

5. McKinnon JG, Kokal WA, Neifeld JP, Kay S. Natural history and treatment of mucosal melanoma. J Surg Oncol. Aug 1989;41(4):222-5. [Medline].

6. Eneroth CM, Lundberg C. Mucosal malignant melanomas of the head and neck with special reference to cases having a prolonged clinical course. Acta Otolaryngol. Nov-Dec 1975;80(5-6):452-8. [Medline].

7. Borden EC. Melanoma and pregnancy. Semin Oncol. Dec 2000;27(6):654-6. [Medline].

8. Allen CM, Pellegrini A. Probable congenital melanocytic nevus of the oral mucosa: case report. Pediatr Dermatol. Jun 1995;12(2):145-8. [Medline].

9. Auluck A, Zhang L, Desai R, Rosin MP. Primary malignant melanoma of maxillary gingiva--a case report and review of the literature. J Can Dent Assoc. May 2008;74(4):367-71. [Medline].

10. Axéll T, Hedin CA. Epidemiologic study of excessive oral melanin pigmentation with special reference to the influence of tobacco habits. Scand J Dent Res. Dec 1982;90(6):434-42. [Medline].

11. Barnes L. Oral mucosal malignant melanoma. In: Surgical Pathology of the Head and Neck. 2^nd ed. New York, NY: Marcel Decker; 2001:410-38.

12. Bessa CF, Santos PJ, Aguiar MC, do Carmo MA. Prevalence of oral mucosal alterations in children from 0 to 12 years old. J Oral Pathol Med. Jan 2004;33(1):17-22. [Medline].

13. Bouquot JE. Common oral lesions found during a mass screening examination. J Am Dent Assoc. Jan 1986;112(1):50-7. [Medline].

14. Brooks JK, Reynolds MA. Ethnobotanical tattooing of the gingiva: literature review and report of a case. J Am Dent Assoc. Aug 2007;138(8):1097-101. [Medline].

15. Buchner A, Hansen LS. Pigmented nevi of the oral mucosa: a clinicopathologic study of 36 new cases and review of 155 cases from the literature. Part II: Analysis of 191 cases. Oral Surg Oral Med Oral Pathol. Jun 1987;63(6):676-82. [Medline].

16. Carpenter WM, Rudd M. Focal, flat pigmentations of the oral mucosa: a clinical approach to the differential diagnosis. J Calif Dent Assoc. Dec 2000;28(12):949-54. [Medline].

17. Collins B, Abernethy J, Barnes L. Oral Malignant Melanoma. eMedicine from WebMD [serial online]. November 8, 2006;Available at http://emedicine.medscape.com/article/1078833-overview.

18. Duchini A, Carethers JM. Peutz-Jeghers Syndrome. eMedicine from WebMD [serial online]. January 4, 2007;Available at http://emedicine.medscape.com/article/182006-overview.

19. Eisen D, Voorhees JJ. Oral melanoma and other pigmented lesions of the oral cavity. J Am Acad Dermatol. Apr 1991;24(4):527-37. [Medline].

20. Elder DE, Clark WH Jr, Elenitsas R, Guerry D 4th, Halpern AC. The early and intermediate precursor lesions of tumor progression in the melanocytic system: common acquired nevi and atypical (dysplastic) nevi. Semin Diagn Pathol. Feb 1993;10(1):18-35. [Medline].

21. Georgescu EF, Stanescu L, Simionescu C, Georgescu I, Ionescu R, Florescu G. Peutz-Jeghers syndrome: case report and literature review. Rom J Morphol Embryol. 2008;49(2):241-5. [Medline].

22. Gollnick A. Malignant melanoma of the oral mucosa. In: Oral Diseases: Textbook and Atlas. Berlin, Germany: Springer-Verlag; 1999:327-31.

23. Jeghers H, McKusick VA, Katz KH. Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. N Engl J Med. Dec 22 1949;241(25):993, illust; passim. [Medline].

24. Kahn MA, Weathers DR, Hoffman JG. Transformation of a benign oral pigmentation to primary oral melanoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Oct 2005;100(4):454-9. [Medline].

25. Kauh YC, Zachian TF. Melasma. Adv Exp Med Biol. 1999;455:491-9. [Medline].

26. Lampe AK, Hampton PJ, Woodford-Richens K, Tomlinson I, Lawrence CM, Douglas FS. Laugier-Hunziker syndrome: an important differential diagnosis for Peutz-Jeghers syndrome. J Med Genet. Jun 2003;40(6):e77. [Medline].

27. Lau JC, Jackson-Boeters L, Daley TD, Wysocki GP, Cherian MG. Metallothionein in human gingival amalgam tattoos. Arch Oral Biol. Nov 2001;46(11):1015-20. [Medline].

28. Lenane P, Powell FC. Oral pigmentation. J Eur Acad Dermatol Venereol. Nov 2000;14(6):448-65. [Medline].

29. Magremanne M, Vervaet C. [Melanoma of the oral mucosa]. Rev Stomatol Chir Maxillofac. Jun 2008;109(3):175-7. [Medline].

30. Manganaro AM, Hammond HL, Dalton MJ, Williams TP. Oral melanoma: case reports and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Dec 1995;80(6):670-6. [Medline].

31. Meleti M, Vescovi P, Mooi WJ, van der Waal I. Pigmented lesions of the oral mucosa and perioral tissues: a flow-chart for the diagnosis and some recommendations for the management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. May 2008;105(5):606-16. [Medline].

32. Mignogna MD, Lo Muzio L, Ruoppo E, Errico M, Amato M, Satriano RA. Oral manifestations of idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a clinical, histopathological and ultrastructural review of 12 cases. Oral Dis. Jan 1999;5(1):80-6. [Medline].

33. Mowad CM, Shrager J, Elenitsas R. Oral pigmentation representing Laugier-Hunziker syndrome. Cutis. Jul 1997;60(1):37-9. [Medline].

34. Neville BW, Damm DD, Allen CM. Oral and Maxillofacial Pathology. Philadelphia, Pa: WB Saunders; 1995.

35. Ozog DM, Gogstetter DS, Scott G, Gaspari AA. Minocycline-induced hyperpigmentation in patients with pemphigus and pemphigoid. Arch Dermatol. Sep 2000;136(9):1133-8. [Medline].

36. Ranganathan K, Reddy BV, Kumarasamy N, Solomon S, Viswanathan R, Johnson NW. Oral lesions and conditions associated with human immunodeficiency virus infection in 300 south Indian patients. Oral Dis. May 2000;6(3):152-7. [Medline].

37. Scully C, Porter S. Orofacial disease: update for the dental clinical team: 4. Red, brown, black and bluish lesions. Dent Update. May 1999;26(4):169-73. [Medline].

38. Siponen M, Salo T. Idiopathic lenticular mucocutaneous pigmentation (Laugier-Hunziker syndrome): a report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Sep 2003;96(3):288-92. [Medline].

39. Terezhalmy GT. Clinical images in oral medicine. Amalgam tattoos. Quintessence Int. Feb 2006;37(2):152-3. [Medline].

40. Tomich CE, Zunt SL. Melanoacanthosis (melanoacanthoma) of the oral mucosa. J Dermatol Surg Oncol. Mar 1990;16(3):231-6. [Medline].

41. Treister NS, Magalnick D, Woo SB. Oral mucosal pigmentation secondary to minocycline therapy: report of two cases and a review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jun 2004;97(6):718-25. [Medline].

42. Venclíkova Z, Benada O, Bártova J, Joska L, Mrklas L. Metallic pigmentation of human teeth and gingiva: morphological and immunological aspects. Dent Mater J. Jan 2007;26(1):96-104. [Medline].

43. Westerman AM, Entius MM, de Baar E, Boor PP, Koole R, van Velthuysen ML, et al. Peutz-Jeghers syndrome: 78-year follow-up of the original family. Lancet. Apr 10 1999;353(9160):1211-5. [Medline].

Further Reading

Keywords

oral pigmented lesions, Peutz-Jeghers syndrome, amalgam tattoo, melanoma, oral cutaneous melanoma, mucosal melanoma, melanoma of the oral cavity, oral malignant melanoma

Contributor Information and Disclosures

Author

Talib Najjar, DMD, MDS, PhD, Professor of Oral and Maxillofacial Surgery and Pathology, University of Medicine and Dentistry of New Jersey
Talib Najjar, DMD, MDS, PhD is a member of the following medical societies: American Society for Clinical Pathology
Disclosure: Nothing to disclose.

Coauthor(s)

Brian J Dorfman, DMD, MD, Staff Physician, Department of Oral and Maxillofacial Surgery, University Hospital, University of Medicine and Dentistry of New Jersey
Brian J Dorfman, DMD, MD is a member of the following medical societies: American Association of Oral and Maxillofacial Surgeons
Disclosure: Nothing to disclose.

Robert A Schwartz, MD, MPH, Professor and Head, Dermatology, Professor of Pathology, Pediatrics, Medicine, and Preventive Medicine and Community Health, UMDNJ-New Jersey Medical School
Robert A Schwartz, MD, MPH is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American College of Physicians, and Sigma Xi
Disclosure: Nothing to disclose.

Medical Editor

James Fulton Jr, MD, PhD, Center for Cosmetic Dermatology; Consultant, Vivant Pharmaceuticals, LLC
James Fulton Jr, MD, PhD is a member of the following medical societies: American Academy of Cosmetic Surgery, American Academy of Dermatology, American Society for Laser Medicine and Surgery, Dermatology Foundation, International Society of Cosmetic and Laser Surgeons, and Skin Cancer Foundation
Disclosure: vivant pharmaceuticals Ownership interest Consulting

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic, Northside Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Managing Editor

Drore Eisen, MD, DDS, Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati
Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, and American Dental Association
Disclosure: Nothing to disclose.

CME Editor

Catherine M Quirk, MD, Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania
Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.