Background
Fissured tongue is a condition frequently seen in the general population that is characterized by grooves that vary in depth and are noted along the dorsal and lateral aspects of the tongue. Although a definitive etiology is unknown, a polygenic mode of inheritance is suspected because the condition is seen clustering in families who are affected. Patients are usually asymptomatic, and the condition is initially noted on routine intraoral examination as an incidental finding. Fissured tongue is also seen in Melkersson-Rosenthal syndrome[1] and Down syndrome and in frequent association with benign migratory glossitis (geographic tongue). Fissured tongue and geographic tongue have been reported in association with chronic granulomatous disease.[2]
Melkersson-Rosenthal syndrome is a rare condition consisting of a triad of persistent or recurring lip or facial swelling, intermittent seventh (facial) nerve paralysis (Bell palsy), and a fissured tongue. The etiology of this condition is also unknown. The orofacial swelling usually manifests as pronounced lip enlargement. It may or may not affect both lips, and it may be tender or erythematous. Histologic examination of this tissue exhibits characteristic noncaseating granulomatous inflammation. Therapy for these lesions is often intralesional steroid injections.[3] The facial paralysis is indistinguishable from Bell palsy, and it may be an inconsistent and intermittent finding with spontaneous resolution. The presence of fissured tongue in association with these other features is diagnostic of the condition.
Pathophysiology
Fissured tongue affects only the tongue and is a finding in Melkersson-Rosenthal syndrome, which consists of a triad of fissured tongue, granulomatous cheilitis, and cranial nerve VII paralysis (Bell palsy).[4, 5]
Epidemiology
Frequency
United States
Overall, the prevalence of fissured tongue within the United States has been reported to range from 2-5% of the population.
International
The prevalence of fissured tongue worldwide varies by geographic location and has been reported to be as high as 21%.[6]
Mortality/Morbidity
Fissured tongue is a totally benign condition and is considered by most to be a variant of normal tongue architecture. When seen in association with Melkersson-Rosenthal syndrome, the morbidity is due not to the fissured tongue but is secondary to the granulomatous inflammation of the lips/facial soft tissues and facial paralysis.
Race
No predilection for any particular race is apparent in fissured tongue.
Sex
Some reports have shown a slight male predilection for fissured tongue.
Age
Although fissured tongue may be diagnosed initially during childhood, it is diagnosed more frequently in adulthood. The prominence of the condition appears to increase with increasing age.
Kaminagakura E, Jorge J Jr. Melkersson Rosenthal syndrome: a histopathologic mystery and dermatologic challenge. J Cutan Pathol. Oct 15 2009;[Medline].
Dar-Odeh NS, Hayajneh WA, Abu-Hammad OA, et al. Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature. BMC Res Notes. Feb 17 2010;3(1):37. [Medline].
Stein SL, Mancini AJ. Melkersson-Rosenthal syndrome in childhood: successful management with combination steroid and minocycline therapy. J Am Acad Dermatol. Nov 1999;41(5 Pt 1):746-8. [Medline].
Alioglu Z, Caylan R, Adanir M, Ozmenoglu M. Melkersson-Rosenthal syndrome: report of three cases. Neurol Sci. Feb 2000;21(1):57-60. [Medline].
Gerressen M, Ghassemi A, Stockbrink G, Riediger D, Zadeh MD. Melkersson-Rosenthal syndrome: case report of a 30-year misdiagnosis. J Oral Maxillofac Surg. Jul 2005;63(7):1035-9. [Medline].
Kovac-Kovacic M, Skaleric U. The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia. J Oral Pathol Med. Aug 2000;29(7):331-5. [Medline].
Eidelman E, Chosack A, Cohen T. Scrotal tongue and geographic tongue: polygenic and associated traits. Oral Surg Oral Med Oral Pathol. Nov 1976;42(5):591-6. [Medline].
Rogers RS. Melkersson-Rosenthal syndrome and orofacial granulomatosis. Dermatol Clin. Apr 1996;14(2):371-9. [Medline].
Reamy BV, Derby R, Bunt CW. Common tongue conditions in primary care. Am Fam Physician. Mar 1 2010;81(5):627-34. [Medline].
Kullaa-Mikkonen A, Sorvari T. Lingua fissurata. A clinical, stereomicroscopic and histopathological study. Int J Oral Maxillofac Surg. Oct 1986;15(5):525-33. [Medline].
Nakane T, Hatakeyama K, Nakamura K, Aihara M, Nakazawa S. Melkersson-Rosenthal syndrome with isolated immunoglobulin E hypogammaglobulinaemia. J Int Med Res. Nov-Dec 2007;35(6):922-5. [Medline].
Shulman JD, Carpenter WM. Prevalence and risk factors associated with geographic tongue among US adults. Oral Dis. Jul 2006;12(4):381-6. [Medline].
Tan O, Atik B, Calka O. Plastic surgical solutions for melkersson-rosenthal syndrome: facial liposuction and cheiloplasty procedures. Ann Plast Surg. Mar 2006;56(3):268-73. [Medline].
Yarom N, Cantony U, Gorsky M. Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. Dermatology. 2004;209(2):88-94. [Medline].
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