Histologic Findings
A biopsy is rarely performed on a fissured tongue because of its characteristic diagnostic clinical appearance; however, histologic examination has shown an increase in the thickness of the lamina propria, loss of filiform papillae of the surface mucosa, hyperplasia of the rete pegs, neutrophilic microabscesses within the epithelium, and a mixed inflammatory infiltrate in the lamina propria.[8]
Kaminagakura E, Jorge J Jr. Melkersson Rosenthal syndrome: a histopathologic mystery and dermatologic challenge. J Cutan Pathol. Oct 15 2009;[Medline].
Dar-Odeh NS, Hayajneh WA, Abu-Hammad OA, et al. Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature. BMC Res Notes. Feb 17 2010;3(1):37. [Medline].
Stein SL, Mancini AJ. Melkersson-Rosenthal syndrome in childhood: successful management with combination steroid and minocycline therapy. J Am Acad Dermatol. Nov 1999;41(5 Pt 1):746-8. [Medline].
Alioglu Z, Caylan R, Adanir M, Ozmenoglu M. Melkersson-Rosenthal syndrome: report of three cases. Neurol Sci. Feb 2000;21(1):57-60. [Medline].
Gerressen M, Ghassemi A, Stockbrink G, Riediger D, Zadeh MD. Melkersson-Rosenthal syndrome: case report of a 30-year misdiagnosis. J Oral Maxillofac Surg. Jul 2005;63(7):1035-9. [Medline].
Kovac-Kovacic M, Skaleric U. The prevalence of oral mucosal lesions in a population in Ljubljana, Slovenia. J Oral Pathol Med. Aug 2000;29(7):331-5. [Medline].
Eidelman E, Chosack A, Cohen T. Scrotal tongue and geographic tongue: polygenic and associated traits. Oral Surg Oral Med Oral Pathol. Nov 1976;42(5):591-6. [Medline].
Rogers RS. Melkersson-Rosenthal syndrome and orofacial granulomatosis. Dermatol Clin. Apr 1996;14(2):371-9. [Medline].
Reamy BV, Derby R, Bunt CW. Common tongue conditions in primary care. Am Fam Physician. Mar 1 2010;81(5):627-34. [Medline].
Kullaa-Mikkonen A, Sorvari T. Lingua fissurata. A clinical, stereomicroscopic and histopathological study. Int J Oral Maxillofac Surg. Oct 1986;15(5):525-33. [Medline].
Nakane T, Hatakeyama K, Nakamura K, Aihara M, Nakazawa S. Melkersson-Rosenthal syndrome with isolated immunoglobulin E hypogammaglobulinaemia. J Int Med Res. Nov-Dec 2007;35(6):922-5. [Medline].
Shulman JD, Carpenter WM. Prevalence and risk factors associated with geographic tongue among US adults. Oral Dis. Jul 2006;12(4):381-6. [Medline].
Tan O, Atik B, Calka O. Plastic surgical solutions for melkersson-rosenthal syndrome: facial liposuction and cheiloplasty procedures. Ann Plast Surg. Mar 2006;56(3):268-73. [Medline].
Yarom N, Cantony U, Gorsky M. Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. Dermatology. 2004;209(2):88-94. [Medline].

