eMedicine Specialties > Dermatology > Diseases of the Oral Mucosa

Eosinophilic Ulcer: Multimedia

Author: Faizan Alawi, DDS, Assistant Professor, Department of Dermatology, Section of Dermatopathology, Hospital of the University of Pennsylvania
Coauthor(s): Paul D Freedman, DDS, Section Chief of Oral Pathology, Assistant Director, Assistant Professor of Surgery, Department of Dental Medicine, The New York Hospital, Cornell University Weill Medical College
Contributor Information and Disclosures

Updated: Oct 2, 2009

Multimedia

A 47-year-old African American woman with an eosi...
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Media file 1: A 47-year-old African American woman with an eosinophilic ulcer on the lateral surface of the tongue. The anterior border of the lesion is raised. Courtesy of Dr Paul D. Freedman.
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A 47-year-old African American woman with an eosi...

A 47-year-old African American woman with an eosinophilic ulcer on the lateral surface of the tongue. The anterior border of the lesion is raised. Courtesy of Dr Paul D. Freedman.

Raised, indurated, nonhealing ulcer on the latera...
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Media file 2: Raised, indurated, nonhealing ulcer on the lateral surface of the tongue. The lesion was related to an adjacent fractured tooth. Courtesy of Dr Paul D. Freedman.
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Raised, indurated, nonhealing ulcer on the latera...

Raised, indurated, nonhealing ulcer on the lateral surface of the tongue. The lesion was related to an adjacent fractured tooth. Courtesy of Dr Paul D. Freedman.

Ulcer on the ventrolateral surface of the tongue....
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Media file 3: Ulcer on the ventrolateral surface of the tongue. The differential diagnosis should include squamous cell carcinoma or an infectious etiology. Courtesy of Dr Paul D. Freedman.
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Ulcer on the ventrolateral surface of the tongue....

Ulcer on the ventrolateral surface of the tongue. The differential diagnosis should include squamous cell carcinoma or an infectious etiology. Courtesy of Dr Paul D. Freedman.

Lesion on the lateral surface of the tongue. Cour...
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Media file 4: Lesion on the lateral surface of the tongue. Courtesy of Dr Paul D. Freedman.
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Lesion on the lateral surface of the tongue. Cour...

Lesion on the lateral surface of the tongue. Courtesy of Dr Paul D. Freedman.

Low-power view showing an ulcerated surface epith...
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Media file 5: Low-power view showing an ulcerated surface epithelium with a dense cellular inflammatory infiltrate underlying the mucosal surface (original magnification X40). Courtesy of Dr Paul D. Freedman.
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Low-power view showing an ulcerated surface epith...

Low-power view showing an ulcerated surface epithelium with a dense cellular inflammatory infiltrate underlying the mucosal surface (original magnification X40). Courtesy of Dr Paul D. Freedman.

Cellular infiltrate composed mainly of large mono...
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Media file 6: Cellular infiltrate composed mainly of large mononuclear cells, including histiocytes and submucosal dendrocytes, eosinophils, and scattered T lymphocytes (original magnification X400). Courtesy of Dr Paul D. Freedman.
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Cellular infiltrate composed mainly of large mono...

Cellular infiltrate composed mainly of large mononuclear cells, including histiocytes and submucosal dendrocytes, eosinophils, and scattered T lymphocytes (original magnification X400). Courtesy of Dr Paul D. Freedman.

Inflammatory infiltrate extending through and bet...
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Media file 7: Inflammatory infiltrate extending through and between muscle bundles (original magnification X400). Courtesy of Dr Paul D. Freedman.
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Inflammatory infiltrate extending through and bet...

Inflammatory infiltrate extending through and between muscle bundles (original magnification X400). Courtesy of Dr Paul D. Freedman.

More on Eosinophilic Ulcer

Overview: Eosinophilic Ulcer
Differential Diagnoses & Workup: Eosinophilic Ulcer
Treatment & Medication: Eosinophilic Ulcer
Follow-up: Eosinophilic Ulcer
Multimedia: Eosinophilic Ulcer
References
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References

  1. Segura S, Pujol RM. Eosinophilic ulcer of the oral mucosa: a distinct entity or a non-specific reactive pattern?. Oral Dis. May 2008;14(4):287-95. [Medline].

  2. Elzay RP. Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede's disease and traumatic eosinophilic granuloma). Oral Surg Oral Med Oral Pathol. May 1983;55(5):497-506. [Medline].

  3. Bhaskar SN, Lilly GE. Traumatic granuloma of the tongue (human and experimental). Oral Surg Oral Med Oral Pathol. Aug 1964;18:206-18. [Medline].

  4. Elovic AE, Gallagher GT, Kabani S, Galli SJ, Weller PF, Wong DT. Lack of TGF-alpha and TGF-beta 1 synthesis by human eosinophils in chronic oral ulcers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jun 1996;81(6):672-81. [Medline].

  5. Gerbig AW, Zala L, Hunziker T. Tumorlike eosinophilic granuloma of the skin. Am J Dermatopathol. Feb 2000;22(1):75-8. [Medline].

  6. Chawla O, Burke GA, MacBean AD. The eosinophilic ulcer revisited. Dent Update. Jan-Feb 2007;34(1):56-7. [Medline].

  7. Rosenberg A, Biesma DH, Sie-Go DM, Slootweg PJ. Primary extranodal CD3O-positive T-cell non-Hodgkins lymphoma of the oral mucosa. Report of two cases. Int J Oral Maxillofac Surg. Feb 1996;25(1):57-9. [Medline].

  8. Pilolli GP, Lucchese A, Scivetti M, Maiorano E, Favia G. Traumatic ulcerative granuloma with stromal eosinophilia of the oral mucosa: histological and immunohistochemical analysis of three cases. Minerva Stomatol. Jan-Feb 2007;56(1-2):73-9. [Medline].

  9. el-Mofty SK, Swanson PE, Wick MR, Miller AS. Eosinophilic ulcer of the oral mucosa. Report of 38 new cases with immunohistochemical observations. Oral Surg Oral Med Oral Pathol. Jun 1993;75(6):716-22. [Medline].

  10. Gopalakrishman R, Miloro M, Allen CM. Indurated ulceration of the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Aug 1996;82(2):119-21. [Medline].

  11. Mezei MM, Tron VA, Stewart WD, Rivers JK. Eosinophilic ulcer of the oral mucosa. J Am Acad Dermatol. Nov 1995;33(5 Pt 1):734-40. [Medline].

  12. Movassaghi K, Goodman ML, Keith D. Ulcerative eosinophilic granuloma: a report of five new cases. Br J Oral Maxillofac Surg. Feb 1996;34(1):115-7. [Medline].

  13. Neville BW, Damm DD, Allen CM. Oral and Maxillofacial Pathology. ed. Philadelphia, Pa: WB Saunders; 1995:213-22.

  14. Regezi JA, Zarbo RJ, Daniels TE, Greenspan JS. Oral traumatic granuloma. Characterization of the cellular infiltrate. Oral Surg Oral Med Oral Pathol. Jun 1993;75(6):723-7. [Medline].

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Further Reading

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Keywords

eosinophilic ulcer, oral eosinophilic ulcer, oral ulcer, oral mucosa ulcer, traumatic ulcerative granuloma with stromal eosinophilia, TUGSE, traumatic granuloma, Riga-Fede disease in infants, ulcerated granuloma eosinophilicum diutinum, eosinophilic granuloma of soft tissue, EU, oral ulcer

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Contributor Information and Disclosures

Author

Faizan Alawi, DDS, Assistant Professor, Department of Dermatology, Section of Dermatopathology, Hospital of the University of Pennsylvania
Faizan Alawi, DDS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology
Disclosure: Nothing to disclose.

Coauthor(s)

Paul D Freedman, DDS, Section Chief of Oral Pathology, Assistant Director, Assistant Professor of Surgery, Department of Dental Medicine, The New York Hospital, Cornell University Weill Medical College
Paul D Freedman, DDS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology and American Dental Association
Disclosure: Nothing to disclose.

Medical Editor

Donald Belsito, MD, Clinical Professor, Department of Internal Medicine, Division of Dermatology, University of Missouri at Kansas City; Private Practice, American Dermatology Associates, LLC
Donald Belsito, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Contact Dermatitis Society, Dermatology Foundation, Kansas Medical Society, Noah Worcester Dermatological Society, Phi Beta Kappa, and Phi Beta Kappa
Disclosure: Nothing to disclose.

Pharmacy Editor

Michael J Wells, MD, Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center
Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Drore Eisen, MD, DDS, Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati
Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, and American Dental Association
Disclosure: Nothing to disclose.

CME Editor

Catherine Quirk, MD, Clinical Assistant Professor, Department of Dermatology, Brown University
Catherine Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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