eMedicine Specialties > Dermatology > Diseases of the Oral Mucosa

Oral Malignant Melanoma: Multimedia

Author: Bobby Collins II, DDS, MS, Associate Professor of Oral and Maxillofacial Pathology, Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine
Coauthor(s): E Leon Barnes Jr, MD, Professor of Pathology and Professor of Otolaryngology, University of Pittsburgh School of Medicine; John Abernethy, MD, Winston-Salem, North Carolina
Contributor Information and Disclosures

Updated: Mar 21, 2008

Multimedia

Man with an ulcerated, blue-black, slightly eleva...Media file 1: Man with an ulcerated, blue-black, slightly elevated lesion in the edentulous, posterior maxilla on the right side. The lesion extends across the residual alveolar ridge onto the palate and onto the facial aspect of the ridge. The diagnosis is oral melanoma. Courtesy of Dr Carl Allen, Ohio State University.
Man with an ulcerated, blue-black, slightly eleva...

Man with an ulcerated, blue-black, slightly elevated lesion in the edentulous, posterior maxilla on the right side. The lesion extends across the residual alveolar ridge onto the palate and onto the facial aspect of the ridge. The diagnosis is oral melanoma. Courtesy of Dr Carl Allen, Ohio State University.

Male Japanese patient with extensive, black-pigme...Media file 2: Male Japanese patient with extensive, black-pigmented and irregularly bordered macule in the maxillary labial mucosa and midline facial gingiva, (teeth 8 and 9). (The patient's fingers are depicted.) The diagnosis is oral melanoma. Courtesy Dr Bob Goode, Tufts University.
Male Japanese patient with extensive, black-pigme...

Male Japanese patient with extensive, black-pigmented and irregularly bordered macule in the maxillary labial mucosa and midline facial gingiva, (teeth 8 and 9). (The patient's fingers are depicted.) The diagnosis is oral melanoma. Courtesy Dr Bob Goode, Tufts University.

Large, blue-black, irregularly bordered lesion on...Media file 3: Large, blue-black, irregularly bordered lesion on the upper lip of a male Japanese patient. The diagnosis is oral melanoma. Courtesy Dr Bob Goode, Tufts University.
Large, blue-black, irregularly bordered lesion on...

Large, blue-black, irregularly bordered lesion on the upper lip of a male Japanese patient. The diagnosis is oral melanoma. Courtesy Dr Bob Goode, Tufts University.

A polypoid mass. Rounded collections or nests of...Media file 4: A polypoid mass. Rounded collections or nests of melanocytes fill the connective tissue and have tropism for the surface epithelium (hematoxylin and eosin, original magnification X2). This mass was excised from the lingual surface of the posterior mandible of an elderly man. The diagnosis is oral melanoma.
A polypoid mass. Rounded collections or nests of...

A polypoid mass. Rounded collections or nests of melanocytes fill the connective tissue and have tropism for the surface epithelium (hematoxylin and eosin, original magnification X2). This mass was excised from the lingual surface of the posterior mandible of an elderly man. The diagnosis is oral melanoma.

A polypoid mass with tumor cells shows strong, po...Media file 5: A polypoid mass with tumor cells shows strong, positive staining with S-100 protein immunohistochemical stain (original magnification X2). The diagnosis is oral melanoma.
A polypoid mass with tumor cells shows strong, po...

A polypoid mass with tumor cells shows strong, positive staining with S-100 protein immunohistochemical stain (original magnification X2). The diagnosis is oral melanoma.

Tumor cell cytoplasmic homatropine methylbromide ...Media file 6: Tumor cell cytoplasmic homatropine methylbromide (HMB-45) immunohistochemical staining (original magnification X40). The diagnosis is oral melanoma.
Tumor cell cytoplasmic homatropine methylbromide ...

Tumor cell cytoplasmic homatropine methylbromide (HMB-45) immunohistochemical staining (original magnification X40). The diagnosis is oral melanoma.

Tumor cells show affinity for the surface epithel...Media file 7: Tumor cells show affinity for the surface epithelium (merging of tumor and epithelium). Cellular pleomorphism and smudged nuclei with pseudoinclusions are noted (hematoxylin and eosin, original magnification X10). The diagnosis is oral melanoma.
Tumor cells show affinity for the surface epithel...

Tumor cells show affinity for the surface epithelium (merging of tumor and epithelium). Cellular pleomorphism and smudged nuclei with pseudoinclusions are noted (hematoxylin and eosin, original magnification X10). The diagnosis is oral melanoma.

Rounded nest of various sized melanocytes with nu...Media file 8: Rounded nest of various sized melanocytes with nuclear pseudoinclusions (hematoxylin and eosin, original magnification X40). The diagnosis is oral melanoma.
Rounded nest of various sized melanocytes with nu...

Rounded nest of various sized melanocytes with nuclear pseudoinclusions (hematoxylin and eosin, original magnification X40). The diagnosis is oral melanoma.

Two, diffusely bordered, dark gray macules in the...Media file 9: Two, diffusely bordered, dark gray macules in the left posterior buccal mucosa adjacent to molar teeth that have been restored. The diagnosis is an amalgam tattoo.
Two, diffusely bordered, dark gray macules in the...

Two, diffusely bordered, dark gray macules in the left posterior buccal mucosa adjacent to molar teeth that have been restored. The diagnosis is an amalgam tattoo.

Clinical photo of an irregularly shaped, tan-brow...Media file 10: Clinical photo of an irregularly shaped, tan-brown macule in the right side of the posterior hard palate. The diagnosis is oral melanotic macule.
Clinical photo of an irregularly shaped, tan-brow...

Clinical photo of an irregularly shaped, tan-brown macule in the right side of the posterior hard palate. The diagnosis is oral melanotic macule.

Clinical photo of the buccal mucosa of a middle-a...Media file 11: Clinical photo of the buccal mucosa of a middle-aged, black woman with a brown-black, irregularly bordered macule that arose suddenly. The patient was unaware of its presence. The diagnosis is oral melanoacanthoma.
Clinical photo of the buccal mucosa of a middle-a...

Clinical photo of the buccal mucosa of a middle-aged, black woman with a brown-black, irregularly bordered macule that arose suddenly. The patient was unaware of its presence. The diagnosis is oral melanoacanthoma.

More on Oral Malignant Melanoma

Overview: Oral Malignant Melanoma
Differential Diagnoses & Workup: Oral Malignant Melanoma
Treatment & Medication: Oral Malignant Melanoma
Follow-up: Oral Malignant Melanoma
Multimedia: Oral Malignant Melanoma
References

References

  1. Elder DE, Clark WH Jr, Elenitsas R, Guerry D 4th, Halpern AC. The early and intermediate precursor lesions of tumor progression in the melanocytic system: common acquired nevi and atypical (dysplastic) nevi. Semin Diagn Pathol. Feb 1993;10(1):18-35. [Medline].

  2. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol. Mar 2000;36(2):152-69. [Medline].

  3. Tanaka N, Amagasa T, Iwaki H, Shioda S, Takeda M, Ohashi K, et al. Oral malignant melanoma in Japan. Oral Surg Oral Med Oral Pathol. Jul 1994;78(1):81-90. [Medline].

  4. Prasad ML, Patel SG, Huvos AG, Shah JP, Busam KJ. Primary mucosal melanoma of the head and neck: a proposal for microstaging localized, Stage I (lymph node-negative) tumors. Cancer. Apr 15 2004;100(8):1657-64. [Medline].

  5. Patel SG, Prasad ML, Escrig M, Singh B, Shaha AR, Kraus DH, et al. Primary mucosal malignant melanoma of the head and neck. Head Neck. Mar 2002;24(3):247-57. [Medline].

  6. McKinnon JG, Kokal WA, Neifeld JP, Kay S. Natural history and treatment of mucosal melanoma. J Surg Oncol. Aug 1989;41(4):222-5. [Medline].

  7. Trotti A, Peters LJ. Role of radiotherapy in the primary management of mucosal melanoma of the head and neck. Semin Surg Oncol. May-Jun 1993;9(3):246-50. [Medline].

  8. Kirkwood JM, Ibrahim JG, Sosman JA, Sondak VK, Agarwala SS, Ernstoff MS, et al. High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801. J Clin Oncol. May 1 2001;19(9):2370-80. [Medline].

  9. Eneroth CM, Lundberg C. Mucosal malignant melanomas of the head and neck with special reference to cases having a prolonged clinical course. Acta Otolaryngol. Nov-Dec 1975;80(5-6):452-8. [Medline].

  10. Borden EC. Melanoma and pregnancy. Semin Oncol. Dec 2000;27(6):654-6. [Medline].

  11. Barker BF, Carpenter WM, Daniels TE, Kahn MA, Leider AS, Lozada-Nur F, et al. Oral mucosal melanomas: the WESTOP Banff workshop proceedings. Western Society of Teachers of Oral Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Jun 1997;83(6):672-9. [Medline].

  12. Eisen D, Voorhees JJ. Oral melanoma and other pigmented lesions of the oral cavity. J Am Acad Dermatol. Apr 1991;24(4):527-37. [Medline].

  13. Kroon BB, Nieweg OE. Management of malignant melanoma. Ann Chir Gynaecol. 2000;89(3):242-50. [Medline].

  14. Prasad ML, Patel S, Hoshaw-Woodard S, Escrig M, Shah JP, Huvos AG, et al. Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. Am J Surg Pathol. Jul 2002;26(7):883-92. [Medline].

Further Reading

Keywords

oral melanoma, oral mucosal melanoma

Contributor Information and Disclosures

Author

Bobby Collins II, DDS, MS, Associate Professor of Oral and Maxillofacial Pathology, Department of Diagnostic Sciences, University of Pittsburgh School of Dental Medicine
Bobby Collins II, DDS, MS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology and American Dental Association
Disclosure: Nothing to disclose.

Coauthor(s)

E Leon Barnes Jr, MD, Professor of Pathology and Professor of Otolaryngology, University of Pittsburgh School of Medicine
E Leon Barnes Jr, MD is a member of the following medical societies: American Academy of Otolaryngology-Head and Neck Surgery, American Association for the Advancement of Science, American Society for Head and Neck Surgery, American Society of Clinical Pathologists, College of American Pathologists, International Academy of Pathology, New York Academy of Sciences, and North American Skull Base Society
Disclosure: Nothing to disclose.

John Abernethy, MD, Winston-Salem, North Carolina
John Abernethy, MD is a member of the following medical societies: American Society of Clinical Pathologists, American Society of Dermatopathology, College of American Pathologists, and United States and Canadian Academy of Pathology
Disclosure: Nothing to disclose.

Medical Editor

Peter Fritsch, MD, Chair, Department of Dermatology and Venereology, University of Innsbruck, Austria
Peter Fritsch, MD is a member of the following medical societies: American Dermatological Association, International Society of Pediatric Dermatology, and Society for Investigative Dermatology
Disclosure: Nothing to disclose.

Pharmacy Editor

Michael J Wells, MD, Associate Professor, Department of Dermatology, Texas Tech University Health Sciences Center
Michael J Wells, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, and Texas Medical Association
Disclosure: Nothing to disclose.

Managing Editor

Drore Eisen, MD, DDS, Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati
Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, and American Dental Association
Disclosure: Nothing to disclose.

CME Editor

Glen H Crawford, MD, Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital
Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons
Disclosure: Nothing to disclose.

Chief Editor

William D James, MD, Paul R Gross Professor of Dermatology, University of Pennsylvania School of Medicine; Vice-Chair, Program Director, Department of Dermatology, University of Pennsylvania Health System
William D James, MD is a member of the following medical societies: American Academy of Dermatology and Society for Investigative Dermatology
Disclosure: elsevier Royalty Other; american college of physicians Honoraria Other

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