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Oral Neurofibroma Differential Diagnoses

  • Author: Indraneel Bhattacharyya, DDS, MSD; Chief Editor: William D James, MD  more...
 
Updated: Sep 04, 2015
 
 

Diagnostic Considerations

Also consider the following:

  • Granular cell tumor
  • Fibroma
  • Scar tissue
  • Neurilemmoma (schwannoma)
  • Leiomyoma
  • Rhabdomyoma
  • Other benign mesenchymal entities

Diffuse neurofibroma (as sometimes seen with neurofibromatosis) may involve the tongue, resulting in macroglossia that may require differentiation from amyloidosis and lymphangioma.

A solitary neurofibroma may be a precursor to neurofibromatosis (also see Neurofibromatosis, Type 1), and the patient should be evaluated with this in mind. Close clinical follow up and/or genetic testing may be required, especially if a lesion recurs multiple times or more than one lesion is seen.

Differential Diagnoses

 
 
Contributor Information and Disclosures
Author

Indraneel Bhattacharyya, DDS, MSD Professor, Department of Oral and Maxillofacial Diagnostic Sciences, Director of Oral and Maxillofacial Pathology Residency Program, University of Florida College of Dentistry

Indraneel Bhattacharyya, DDS, MSD is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, American Dental Association, International Association for Dental Research, International Association of Oral Pathologists, American Association for Dental Research

Disclosure: Nothing to disclose.

Coauthor(s)

Donald Cohen, DMD, MS Professor of Oral and Maxillofacial Pathology, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry

Donald Cohen, DMD, MS is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology

Disclosure: Nothing to disclose.

Specialty Editor Board

David F Butler, MD Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic

David F Butler, MD is a member of the following medical societies: American Medical Association, Alpha Omega Alpha, Association of Military Dermatologists, American Academy of Dermatology, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Phi Beta Kappa

Disclosure: Nothing to disclose.

Drore Eisen, MD, DDS Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati

Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, American Dental Association

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Neil Shear, MD Professor and Chief of Dermatology, Professor of Medicine, Pediatrics and Pharmacology, University of Toronto Faculty of Medicine; Head of Dermatology, Sunnybrook Women's College Health Sciences Center and Women's College Hospital, Canada

Neil Shear, MD is a member of the following medical societies: Canadian Medical Association, Ontario Medical Association, Royal College of Physicians and Surgeons of Canada, Canadian Dermatology Association, American Academy of Dermatology, American Society for Clinical Pharmacology and Therapeutics

Disclosure: Nothing to disclose.

References
  1. Depprich R, Singh DD, Reinecke P, Kübler NR, Handschel J. Solitary submucous neurofibroma of the mandible: review of the literature and report of a rare case. Head Face Med. Nov/2009. 13;5:24.:24. [Medline]. [Full Text].

  2. Marocchio LS, Oliveira DT, Pereira MC, Soares CT, Fleury RN. Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years. Clin Oral Investig. 2007 Jun. 11(2):165-9. [Medline].

  3. Johann AC, Caldeira PC, Souto GR, Freitas JB, Mesquita RA. Extra-osseous solitary hard palate neurofibroma. Braz J Otorhinolaryngol. 2008 Mar-Apr. 74(2):317. [Medline].

  4. Shimoyama T, Kato T, Nasu D, Kaneko T, Horie N, Ide F. Solitary neurofibroma of the oral mucosa: a previously undescribed variant of neurofibroma. J Oral Sci. 2002 Mar. 44(1):59-63. [Medline].

  5. Vivek N, Manikandhan R, James PC, Rajeev R. Solitary intraosseous neurofibroma of mandible. Indian J Dent Res. 2006 Jul-Sep. 17(3):135-8. [Medline].

  6. De Raedt T, Maertens O, Chmara M, et al. Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes Chromosomes Cancer. 2006 Oct. 45(10):893-904. [Medline].

  7. Gomez-Oliveira G, Fernandez-Alba Luengo J. Martin-Sastre R, Patino-Seijas B, Lopez-Cedrun-Cembranos JL. Plexiform neurofibroma of the cheek mucosa. A case report. Med oral. May-Jul 2004. 9:263-7. [Medline]. [Full Text].

 
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Intrabony presentation of neurofibroma. Note the extensive bone destruction caused by the lesion.
Multiple neurofibromas on the tongue.
Solitary neurofibroma on the hard palate.
An 11-year-old girl with an asymptomatic raised lesion on the anterior mandibular gingiva.
Isolated palatal lesion in a 27-year-old African American woman.
 
 
 
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