Oral Neurofibroma Follow-up
- Author: Indraneel Bhattacharyya, DDS, MSD; Chief Editor: William D James, MD more...
Further Outpatient Care
Solitary neurofibromas are treated by surgical excision and exhibit very low recurrence. The patient should be instructed to report any new growth seen in the area or any abnormal sensations, such as tingling. These signs may signify a recurrence, and lesions may require repeat excision.
No special precaution is recommended for prevention of recurrence. Surgical excision is usually curative.
A possible, although extremely rare, complication may be recurrence of the lesion. Other potential complications that may be seen are purely associated with surgical treatment and may include scarring and numbness.
Solitary neurofibromas have a good prognosis, with only rare instances of local recurrence after excision. However, in neurofibromatosis, a larger proportion of patients develop recurrence after excision, and multiple recurrences are associated with malignant transformation. Spontaneous malignant transformation of 1 or more lesions is also reported. The rate of transformation is estimated to be 5-15%. This neurofibrosarcomatous change has an extremely poor prognosis, and distant metastasis is common. The average 5-year survival rate is dismal and ranges around 10-15%. A study involving 66 cases of head and neck neurofibromas reported that no recurrence of the neurofibromas was detected after surgical removal in approximately 33% of the patients during follow-up ranging from 3-230 months.
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