eMedicine Specialties > Dermatology > Diseases of the Oral Mucosa
Oral Neurofibroma: Treatment & Medication
Updated: Oct 7, 2009
- Overview
- Differential Diagnoses & Workup
- Treatment & Medication
- Follow-up
- Multimedia
Treatment
Surgical Care
Solitary oral neurofibromas are usually treated by surgical excision, depending on the extent and the site. However, for neurofibromas associated with neurofibromatosis, surgical removal is attempted only for functional or cosmetic reasons. Surgical removal may result in recurrence, and multiple recurrences have been associated with malignant transformation.
Consultations
Many authorities believe that any individual presenting with neurofibroma at an early age (<20 y) should be referred for genetic studies to rule out the possibility of neurofibromatosis. Consultation with a geneticist and a family physician may be critical in establishing a diagnosis of neurofibromatosis.
More on Oral Neurofibroma |
| Overview: Oral Neurofibroma |
| Differential Diagnoses & Workup: Oral Neurofibroma |
Treatment & Medication: Oral Neurofibroma |
| Follow-up: Oral Neurofibroma |
| Multimedia: Oral Neurofibroma |
| References |
| « Previous Page | Next Page » |
References
Marocchio LS, Oliveira DT, Pereira MC, Soares CT, Fleury RN. Sporadic and multiple neurofibromas in the head and neck region: a retrospective study of 33 years. Clin Oral Investig. Jun 2007;11(2):165-9. [Medline].
Johann AC, Caldeira PC, Souto GR, Freitas JB, Mesquita RA. Extra-osseous solitary hard palate neurofibroma. Braz J Otorhinolaryngol. Mar-Apr 2008;74(2):317. [Medline].
Shimoyama T, Kato T, Nasu D, Kaneko T, Horie N, Ide F. Solitary neurofibroma of the oral mucosa: a previously undescribed variant of neurofibroma. J Oral Sci. Mar 2002;44(1):59-63. [Medline].
Vivek N, Manikandhan R, James PC, Rajeev R. Solitary intraosseous neurofibroma of mandible. Indian J Dent Res. Jul-Sep 2006;17(3):135-8. [Medline].
De Raedt T, Maertens O, Chmara M, et al. Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. Genes Chromosomes Cancer. Oct 2006;45(10):893-904. [Medline].
Allen CM, Miloro M. Gingival lesion of recent onset in a patient with neurofibromatosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Dec 1997;84(6):595-7. [Medline].
Bekisz O, Darimont F, Rompen EH. Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: a case report. J Clin Periodontol. May 2000;27(5):361-5. [Medline].
Chrysomali E, Papanicolaou SI, Dekker NP, Regezi JA. Benign neural tumors of the oral cavity: a comparative immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Oct 1997;84(4):381-90. [Medline].
Geist JR, Gander DL, Stefanac SJ. Oral manifestations of neurofibromatosis types I and II. Oral Surg Oral Med Oral Pathol. Mar 1992;73(3):376-82. [Medline].
Gutmann DH, Aylsworth A, Carey JC, et al. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2. JAMA. Jul 2 1997;278(1):51-7. [Medline].
Marocchio LS, Pereira MC, Soares CT, Oliveira DT. Oral plexiform neurofibroma not associated with neurofibromatosis type I: case report. J Oral Sci. Sep 2006;48(3):157-60. [Medline].
Neville BW, Hann J, Narang R, Garen P. Oral neurofibrosarcoma associated with neurofibromatosis type I. Oral Surg Oral Med Oral Pathol. Oct 1991;72(4):456-61. [Medline].
Powell CA, Stanley CM, Bannister SR, McDonnell HT, Moritz AJ, Deas DE. Palatal neurofibroma associated with localized periodontitis. J Periodontol. Feb 2006;77(2):310-5. [Medline].
Regezi JA, Sciubba JJ. Connective tissue lesions. In: Oral Pathology: Clinical Pathologic Correlations. 3rd ed. Philadelphia, Pa: WB Saunders; 1999:204-8.
Shapiro SD, Abramovitch K, Van Dis ML, et al. Neurofibromatosis: oral and radiographic manifestations. Oral Surg Oral Med Oral Pathol. Oct 1984;58(4):493-8. [Medline].
Skouteris CA. Incidence of solitary intraosseous neurofibroma of the maxilla. J Oral Maxillofac Surg. Feb 1994;52(2):205-6. [Medline].
Wright BA, Jackson D. Neural tumors of the oral cavity. A review of the spectrum of benign and malignant oral tumors of the oral cavity and jaws. Oral Surg Oral Med Oral Pathol. Jun 1980;49(6):509-22. [Medline].
Zachariades N, Mezitis M, Vairaktaris E, et al. Benign neurogenic tumors of the oral cavity. Int J Oral Maxillofac Surg. Feb 1987;16(1):70-6. [Medline].
Further Reading
Keywords
oral neurofibroma, neurofibroma, neurofibromatosis, von Recklinghausen's disease of the skin, von Recklinghausen disease, fibroma molluscum
Treatment & Medication: Oral Neurofibroma