eMedicine Specialties > Dermatology > Diseases of the Oral Mucosa

Chemotherapy-Induced Oral Mucositis: Multimedia

Author: Nathaniel S Treister, DMD, DMSc, Assistant Professor, Harvard School of Dental Medicine; Consulting Staff, Division of Oral and Maxillofacial Surgery, Oral Medicine And Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute
Coauthor(s): Sook-Bin Woo, DMD, MS, BDS, MMSc, Associate Professor, Chief, Division of Oral Medicine, Department of Oral Medicine and Diagnostic Services, Harvard School of Dental Medicine; Consulting Staff, Brigham and Women's Hospital, Dana Farber Cancer Institute, Beth Israel/Deaconess Medical Center
Contributor Information and Disclosures

Updated: Oct 31, 2008

Multimedia

Hairy tongue.Media file 1: Hairy tongue.
Hairy tongue.

Hairy tongue.

Multiple mucoceles on the hard palate.Media file 2: Multiple mucoceles on the hard palate.
Multiple mucoceles on the hard palate.

Multiple mucoceles on the hard palate.

Erythematous oral mucositis lesion on the buccal ...Media file 3: Erythematous oral mucositis lesion on the buccal mucosa.
Erythematous oral mucositis lesion on the buccal ...

Erythematous oral mucositis lesion on the buccal mucosa.

Ulcerative oral mucositis lesion on the buccal mu...Media file 4: Ulcerative oral mucositis lesion on the buccal mucosa.
Ulcerative oral mucositis lesion on the buccal mu...

Ulcerative oral mucositis lesion on the buccal mucosa.

Ulcerative oral mucositis lesion on the lateral a...Media file 5: Ulcerative oral mucositis lesion on the lateral and ventral surfaces of the tongue.
Ulcerative oral mucositis lesion on the lateral a...

Ulcerative oral mucositis lesion on the lateral and ventral surfaces of the tongue.

Ulcerative oral mucositis lesions on the labial m...Media file 6: Ulcerative oral mucositis lesions on the labial mucosa and the floor of the mouth.
Ulcerative oral mucositis lesions on the labial m...

Ulcerative oral mucositis lesions on the labial mucosa and the floor of the mouth.

Oral pseudomembranous candidiasis on the hard pal...Media file 7: Oral pseudomembranous candidiasis on the hard palate.
Oral pseudomembranous candidiasis on the hard pal...

Oral pseudomembranous candidiasis on the hard palate.

Herpes simplex virus ulceration on the dorsal sur...Media file 8: Herpes simplex virus ulceration on the dorsal surface of the tongue.
Herpes simplex virus ulceration on the dorsal sur...

Herpes simplex virus ulceration on the dorsal surface of the tongue.

Herpes simplex virus ulceration on the hard and s...Media file 9: Herpes simplex virus ulceration on the hard and soft palate. Note lesions on the right upper lip and the dorsum of the tongue.
Herpes simplex virus ulceration on the hard and s...

Herpes simplex virus ulceration on the hard and soft palate. Note lesions on the right upper lip and the dorsum of the tongue.

Acute graft versus host disease involving the dor...Media file 10: Acute graft versus host disease involving the dorsal surface of the tongue. This is a keratinized site that is usually not involved by oral mucositis.
Acute graft versus host disease involving the dor...

Acute graft versus host disease involving the dorsal surface of the tongue. This is a keratinized site that is usually not involved by oral mucositis.

More on Chemotherapy-Induced Oral Mucositis

Overview: Chemotherapy-Induced Oral Mucositis
Differential Diagnoses & Workup: Chemotherapy-Induced Oral Mucositis
Treatment & Medication: Chemotherapy-Induced Oral Mucositis
Follow-up: Chemotherapy-Induced Oral Mucositis
Multimedia: Chemotherapy-Induced Oral Mucositis
References

References

  1. Ruescher TJ, Sodeifi A, Scrivani SJ, Kaban LB, Sonis ST. The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies. Cancer. Jun 1 1998;82(11):2275-81. [Medline].

  2. Bochud PY, Calandra T, Francioli P. Bacteremia due to viridans streptococci in neutropenic patients: a review. Am J Med. Sep 1994;97(3):256-64. [Medline].

  3. Stiff PJ, Erder H, Bensinger WI, Emmanouilides C, Gentile T, Isitt J, et al. Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT). Bone Marrow Transplant. Feb 2006;37(4):393-401. [Medline].

  4. Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. Mar 1 2007;109(5):820-31. [Medline].

  5. Spielberger R, Stiff P, Bensinger W, Gentile T, Weisdorf D, Kewalramani T, et al. Palifermin for oral mucositis after intensive therapy for hematologic cancers. N Engl J Med. Dec 16 2004;351(25):2590-8. [Medline].

  6. Barasch A, Peterson DE. Risk factors for ulcerative oral mucositis in cancer patients: unanswered questions. Oral Oncol. Feb 2003;39(2):91-100. [Medline].

  7. Epstein JB, Schubert MM. Oral mucositis in myelosuppressive cancer therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Sep 1999;88(3):273-6. [Medline].

  8. Peterson DE. Research advances in oral mucositis. Curr Opin Oncol. Jul 1999;11(4):261-6. [Medline].

  9. Plevová P. Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review. Oral Oncol. Sep 1999;35(5):453-70. [Medline].

  10. Rapoport AP, Miller Watelet LF, Linder T, Eberly S, Raubertas RF, Lipp J, et al. Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants. J Clin Oncol. Aug 1999;17(8):2446-53. [Medline].

  11. Sonis ST. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol. Jan 1998;34(1):39-43. [Medline].

  12. Sonis ST. Oral complications. Cancer Med. 2000;5:2371-9.

  13. Sonis ST. Oral mucositis in cancer therapy. J Support Oncol. Nov-Dec 2004;2(6 Suppl 3):3-8. [Medline].

  14. Spijkervet FK, Sonis ST. New frontiers in the management of chemotherapy-induced mucositis. Curr Opin Oncol. Aug 1998;10 Suppl 1:S23-7. [Medline].

  15. Wilkes JD. Prevention and treatment of oral mucositis following cancer chemotherapy. Semin Oncol. Oct 1998;25(5):538-51. [Medline].

  16. Woo SB, Lee SJ, Schubert MM. Graft-vs.-host disease. Crit Rev Oral Biol Med. 1997;8(2):201-16. [Medline].

  17. Woo SB, Sonis ST, Monopoli MM, Sonis AL. A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer. Sep 1 1993;72(5):1612-7. [Medline].

Further Reading

Keywords

oral mucositis, OM, hairy tongue, chemotherapy complications, ulceration of the oral mucosa, ulcers in the mouth, alpha-hemolytic streptococcal infection, viridans streptococci, septicemia, leukoedema, atrophy of the mucosa, chemotherapy-related oral ulcers, ulcerative OM, ulcerative oral mucositis, HSV infection

Contributor Information and Disclosures

Author

Nathaniel S Treister, DMD, DMSc, Assistant Professor, Harvard School of Dental Medicine; Consulting Staff, Division of Oral and Maxillofacial Surgery, Oral Medicine And Dentistry, Brigham and Women's Hospital and Dana Farber Cancer Institute
Nathaniel S Treister, DMD, DMSc is a member of the following medical societies: American Academy of Oral Medicine and American Dental Association
Disclosure: Nothing to disclose.

Coauthor(s)

Sook-Bin Woo, DMD, MS, BDS, MMSc, Associate Professor, Chief, Division of Oral Medicine, Department of Oral Medicine and Diagnostic Services, Harvard School of Dental Medicine; Consulting Staff, Brigham and Women's Hospital, Dana Farber Cancer Institute, Beth Israel/Deaconess Medical Center
Sook-Bin Woo, DMD, MS, BDS, MMSc is a member of the following medical societies: American Academy of Oral and Maxillofacial Pathology, American Academy of Oral Medicine, and American Dental Association
Disclosure: Nothing to disclose.

Medical Editor

Ponciano D Cruz Jr, MD, Vice-Chair, JB Shelmire Professor, Department of Dermatology, University of Texas Southwestern Medical Center
Ponciano D Cruz Jr, MD is a member of the following medical societies: Texas Medical Association
Disclosure: Nothing to disclose.

Pharmacy Editor

David F Butler, MD, Professor of Dermatology, Texas A&M University College of Medicine; Chair, Department of Dermatology, Director, Dermatology Residency Training Program, Scott and White Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, American Society for Dermatologic Surgery, American Society for MOHS Surgery, Association of Military Dermatologists, and Phi Beta Kappa
Disclosure: 3M Pharmaceutical Grant/research funds Other; Graceway Pharmaceuticals Grant/research funds Other

Managing Editor

Drore Eisen, MD, DDS, Consulting Staff, Department of Dermatology, Dermatology Research Associates of Cincinnati
Drore Eisen, MD, DDS is a member of the following medical societies: American Academy of Dermatology, American Academy of Oral Medicine, and American Dental Association
Disclosure: Nothing to disclose.

CME Editor

Glen H Crawford, MD, Assistant Clinical Professor, Department of Dermatology, University of Pennsylvania School of Medicine; Chief, Division of Dermatology, The Pennsylvania Hospital
Glen H Crawford, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Medical Association, Phi Beta Kappa, and Society of USAF Flight Surgeons
Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD, Director, Department of Dermatology, Geisinger Medical Center
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.

 
 
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