No treatment is usually needed, and lesions tend to regress spontaneously in many cases. Intralesional steroids may be helpful in some cases. When associated with an autoimmune disorder, antimalarials or systemic corticosteroids may be needed.
No surgical care is needed as a rule. If cosmetically a problem, a combination of liposuction and localized fat transplantation may be used. Breast augmentation has been peformed in selected patients with truncal lipoatrophy. 
Follow-up care may be useful to document spontaneous regression and/or to make decisions for further treatment. Patients may need to be monitored in cases preceded by panniculitis, particularly in cases associated with a connective-tissue disorder.