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Erythema Elevatum Diutinum Medication

  • Author: Firas G Hougeir, MD; Chief Editor: William D James, MD  more...
 
Updated: Jun 03, 2016
 

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Sulfones

Class Summary

These agents have been demonstrated to effectively suppress the manifestations of erythema elevatum diutinum.

Dapsone (Avlosulfon)

 

Dapsone is the drug of choice. It is bactericidal and bacteriostatic against mycobacteria; its mechanism of action is similar to that of sulfonamides, where competitive antagonists of PABA prevent the formation of folic acid, inhibiting bacterial growth.

The dose depends on the patient. The optimal dose should be determined by the physician. Dapsone is available for oral intake in 25- and 100-mg scored tablets. It is not considered to have an effect on the growth and development of the child.

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Vitamins

Class Summary

These agents may suppress erythema elevatum diutinum. They are essential for normal DNA synthesis and are used in tissue respiration, lipid metabolism, and glycogenolysis.

Niacin (Vitamin B-3)

 

A 1980 study showed niacinamide to be helpful in suppressing clinical manifestations of erythema elevatum diutinum. It has also been used for the management of many disorders, including livedoid vasculitis and leprosy. The presumed mechanism of action is as an anti-inflammatory agent and as a vasodilator. It is mainly used for the treatment and prevention of pellagra and niacin or tryptophan deficiency. It is available for oral intake in 50-, 100-, and 500-mg tablets.

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Contributor Information and Disclosures
Author

Firas G Hougeir, MD Staff Dermatologist, Private Practice, Georgia

Firas G Hougeir, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

James A Yiannias, MD Associate Professor of Dermatology, Associate Dean, Mayo School of Graduate Medical Education, Mayo Foundation for Medical Education and Research; Vice Chair, Medical Division, Department of Dermatology, Mayo Clinic Scottsdale

James A Yiannias, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Christen M Mowad, MD Professor, Department of Dermatology, Geisinger Medical Center

Christen M Mowad, MD is a member of the following medical societies: Alpha Omega Alpha, Noah Worcester Dermatological Society, Pennsylvania Academy of Dermatology, American Academy of Dermatology, Phi Beta Kappa

Disclosure: Nothing to disclose.

Chief Editor

William D James, MD Paul R Gross Professor of Dermatology, Vice-Chairman, Residency Program Director, Department of Dermatology, University of Pennsylvania School of Medicine

William D James, MD is a member of the following medical societies: American Academy of Dermatology, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Additional Contributors

Carrie L Kovarik, MD Assistant Professor of Dermatology, Dermatopathology, and Infectious Diseases, University of Pennsylvania School of Medicine

Carrie L Kovarik, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

References
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