Erythema Elevatum Diutinum Medication

  • Author: Firas G Hougeir, MD; Chief Editor: Dirk M Elston, MD   more...
 
Updated: Jun 3, 2010
 

Medication Summary

The goals of pharmacotherapy are to reduce morbidity and to prevent complications.

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Sulfones

Class Summary

These agents have been demonstrated to effectively suppress the manifestations of erythema elevatum diutinum.

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Dapsone (Avlosulfon)

 

DOC in patients with EED. Bactericidal and bacteriostatic against mycobacteria; mechanism of action is similar to that of sulfonamides where competitive antagonists of PABA prevent formation of folic acid, inhibiting bacterial growth.

Dose depends on patient. Optimal dose should be determined by physician. Available for oral intake in 25 mg and 100 mg scored tablets. Not considered to have an effect on growth and development of the child.

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Vitamins

Class Summary

These agents may suppress erythema elevatum diutinum. They are essential for normal DNA synthesis and are used in tissue respiration, lipid metabolism, and glycogenolysis.

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Niacin (Vitamin B-3)

 

A 1980 study showed niacinamide to be helpful in suppressing clinical manifestations of EED. Has also been used for management of many disorders, including livedoid vasculitis and leprosy. Presumed mechanism of action is as an anti-inflammatory agent and as a vasodilator. Mainly used for treatment and prevention of pellagra and niacin or tryptophan deficiency. Available for oral intake in 50-, 100-, and 500-mg tab.

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Contributor Information and Disclosures
Author

Firas G Hougeir, MD  Staff Physician, Department of Dermatology, Mayo Clinic Scottsdale

Firas G Hougeir, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Coauthor(s)

James A Yiannias, MD  Associate Professor of Dermatology, Associate Dean, Mayo School of Graduate Medical Education, Mayo Foundation for Medical Education and Research; Vice Chair, Medical Division, Department of Dermatology, Mayo Clinic Scottsdale

James A Yiannias, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Specialty Editor Board

Carrie L Kovarik, MD  Assistant Professor of Dermatology, Dermatopathology, and Infectious Diseases, University of Pennsylvania School of Medicine

Carrie L Kovarik, MD is a member of the following medical societies: Alpha Omega Alpha

Disclosure: Nothing to disclose.

Richard P Vinson, MD  Assistant Clinical Professor, Department of Dermatology, Texas Tech University School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Association of Military Dermatologists, Texas Dermatological Society, and Texas Medical Association

Disclosure: Nothing to disclose.

Christen M Mowad, MD  Associate Professor, Department of Dermatology, Geisinger Medical Center

Christen M Mowad, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, and Phi Beta Kappa

Disclosure: Nothing to disclose.

Catherine M Quirk, MD  Clinical Assistant Professor, Department of Dermatology, University of Pennsylvania

Catherine M Quirk, MD is a member of the following medical societies: Alpha Omega Alpha and American Academy of Dermatology

Disclosure: Nothing to disclose.

Chief Editor

Dirk M Elston, MD  Director, Department of Dermatology, Geisinger Medical Center

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

References

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Plaques and papular lesions on the wrists and the dorsum of the hands and the digits of a patient with erythema elevatum diutinum.
Nodular lesions on the knees of a patient with erythema elevatum diutinum.
Fibrinoid changes in dermal blood vessels with polymorphonuclear neutrophil infiltration.
 
 
 
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